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    DRUG CLASS:

    Guanylate cyclase stimulant

    Related drugs:
    3d
    Spatial metabolomics combined with MALDI-MSI unveils gut-brain axis mechanisms of angelica dahurica radix in migraine rats. (PubMed, Phytomedicine)
    Baizhi alleviates migraine through multi-target regulation of the gut-brain axis, including intestinal barrier repair, gut microbiota remodeling, and cerebral metabolic restoration. Notably, this study on Baizhi represents the first integration of spatial metabolomics (MALDI-MSI) with gut microbiome and systemic metabolomics to elucidate migraine mechanisms, providing a novel multi-omics strategy for understanding the holistic therapeutic effects of traditional Chinese medicine. These findings provide a mechanistic basis for its clinical application in migraine treatment.
    Preclinical • Journal • Metabolomic study
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    TNFA (Tumor Necrosis Factor-Alpha) • TJP1 (Tight Junction Protein 1) • OCLN (Occludin)
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    nitroglycerin
    4d
    Effect of discontinuation of riociguat on right heart function in patients with chronic thromboembolic pulmonary hypertension after combination therapy (ChiCTR2500099401)
    P=N/A, N=68, Not yet recruiting, Beijing Chao-Yang Hospital, Capital Medical University; Beijing Chao-Yang Hospital, Capital Medical University | Phase classification: P4 --> P=N/A
    Phase classification
    4d
    A prospective, randomized, controlled clinical study on the treatment of patients with decompensated chronic heart failure and diuretic resistance with recombinant human brain natriuretic peptide (ChiCTR2500114713)
    P=N/A, N=100, Not yet recruiting, Tianjin Chest Hospital; Tianjin Chest Hospital
    New trial
    4d
    Study on the efficacy and safety of recombinant human brain natriuretic peptide (Xinhuosu) in the treatment of acute heart failure patients (randomized controlled trial) Study on the efficacy and safety of recombinant human brain natriuretic peptide (Xinhuosu) in the treatment of acute heart failure patients (randomized controlled trial) (ChiCTR2500112523)
    P=N/A, N=514, Not yet recruiting, Fuwai Hospital, Chinese Academy of Medical Sciences; Fuwai Hospital, Chinese Academy of Medical Sciences
    New trial
    4d
    Kuanxiong Aerosol vs Nitroglycerin for Acute Chest Symptoms: A Multicenter Randomized Trial on Efficacy and Safety (ChiCTR2500112108)
    P=N/A, N=1000, Not yet recruiting, Peking University First Hospital; Peking University First Hospital
    New trial
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    nitroglycerin
    6d
    Trial of Inhaled Nitric Oxide (iNO) on Ischemia / Reperfusion Injury During Orthotopic Liver Transplantation With Marginal Grafts (clinicaltrials.gov)
    P2, N=23, Completed, Baylor Research Institute | Unknown status --> Completed
    Trial completion
    11d
    Regulation of Vascular Tone of Preglomerular Renal Vasculature by Caldesmon. (PubMed, J Am Heart Assoc)
    This study provides cumulative evidence that caldesmon is a marker of age and inflammation-related changes in preglomerular vascular function. Our work supports the view that in the renal vasculature, caldesmon expression is age dependent and determines its sensitivity to the RhoA-associated protein kinase/p21-activated protein kinase 1 regulatory pathway.
    Journal
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    RHOA (Ras homolog family member A)
    1m
    Loupe-Assisted Varicocelectomy With Nitroglycerin Instillation Versus Microscopic Varicocelectomy (clinicaltrials.gov)
    P=N/A, N=60, Completed, Fayoum University Hospital
    New trial
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    nitroglycerin
    1m
    Comparison Between the Use of Phentolamine Versus Glyceryl Trinitrate for Their Effect on Renal Function in Pre-eclampsia Patients in ICU (clinicaltrials.gov)
    P4, N=170, Completed, Assiut University | Not yet recruiting --> Completed
    Trial completion
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    nitroglycerin
    2ms
    NoCovid: Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19 (clinicaltrials.gov)
    P2, N=70, Terminated, Massachusetts General Hospital | Active, not recruiting --> Terminated; COVID wave passed
    Trial termination
    2ms
    NOpreventCOVID: NO Prevention of COVID-19 for Healthcare Providers (clinicaltrials.gov)
    P2, N=24, Terminated, Massachusetts General Hospital | Active, not recruiting --> Terminated; COVID wave passed and we closed the study prematurely
    Trial termination
    2ms
    SPY NITROPASTE: Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging. (clinicaltrials.gov)
    P1, N=15, Not yet recruiting, Johns Hopkins University | Initiation date: Dec 2025 --> Mar 2026 | Trial primary completion date: Dec 2026 --> Mar 2027
    Trial initiation date • Trial primary completion date
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    nitroglycerin