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    BIOMARKER:

    GSTP1 rs1138272

    i
    Other names: GSTP1, FAEES3, GST3, GSTP, Glutathione S-transferase pi 1
    Entrez ID:
    2950
    Related biomarkers:
    Expression
    Mutation
    15d
    The association of combined GSTM1, GSTT1, and GSTP1 genetic polymorphisms with lung cancer risk in male Iraqi Waterpipe Tobacco (Nargila) smokers. (PubMed, Cancer Epidemiol)
    WP smoking and GSTs genetic polymorphisms might be associated with an increased risk of developing LC. However, our data did not confirm an association between GST polymorphisms alone and the risk of LC.
    Journal
    |
    GSTP1 (Glutathione S-transferase pi 1) • GSTM1 (Glutathione S-transferase mu 1) • GSTT1 (Glutathione S-transferase theta 1)
    |
    GSTP1 rs1138272
    1year
    GPX3 rs8177412 Polymorphism Modifies Risk of Upper Urothelial Tumors in Patients with Balkan Endemic Nephropathy. (PubMed, Medicina (Kaunas))
    Regarding GPX3 rs8177412 polymorphism, the gene variant that confers lower expression is associated with significant increase in upper urothelial carcinoma risk. Therefore, BEN patients carrying variant GPX3 genotype should be more frequently monitored for possible upper tract urothelial carcinoma development.
    Journal
    |
    KEAP1 (Kelch Like ECH Associated Protein 1) • ABCB1 (ATP Binding Cassette Subfamily B Member 1)
    |
    GSTP1 rs1138272
    2years
    Pharmacogenetics of Taxane-Induced Neurotoxicity in Breast Cancer: Systematic Review and Meta-Analysis. (PubMed, Clin Transl Sci)
    In conclusion, through systematic review and meta-analysis, we found that polymorphisms, and particularly 13 SNPs, are associated with TIPN, suggesting that genetics does play a role in interindividual predisposition. Further studies could potentially use these findings to develop individual risk profiles and guide decision making.
    Retrospective data • Review • Journal
    |
    BCL6 (B-cell CLL/lymphoma 6) • ABCB1 (ATP Binding Cassette Subfamily B Member 1) • GSTP1 (Glutathione S-transferase pi 1) • CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4) • EPHA5 (EPH Receptor A5) • CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) • EPHA6 (EPH Receptor A6)
    |
    GSTP1 rs1138272
    over2years
    Single-nucleotide polymorphisms and the effectiveness of taxane-based chemotherapy in premenopausal breast cancer: a population-based cohort study in Denmark. (PubMed, Breast Cancer Res Treat)
    Docetaxel effectiveness was influenced by SNPs in GSTP1, CYP3A, and SLCO1B1 in premenopausal women with non-distant metastatic breast cancer, likely related to altered docetaxel pharmacokinetics. These SNPs may help determine individual benefit from taxane-based chemotherapy.
    Journal
    |
    GSTP1 (Glutathione S-transferase pi 1)
    |
    GSTP1 rs1138272 • SLCO1B1 rs2306283
    |
    docetaxel • cyclophosphamide