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BIOMARKER:

GSTP1 overexpression

i
Other names: GSTP1, FAEES3, GST3, GSTP, Glutathione S-transferase pi 1
Entrez ID:
22d
We analyzed cells at 72h of co-culture, MM cells (OPM-2, U266, AMO-1) with MSCs or treatments with cytostatics, bortezomib (BTZ), melphalan and lenalidomide. Further investigations will reveal behavior of MMs adhered to MSCs. Increased β-galactosidase activity and variable alkaline phosphatase activity in MSCs after co-culture suggests MM-MSC interactions may contribute to the senescent profile of MSC Conclusion Although MSCs and cytostatics might show similar effects in terms of contribution to the chemoresistance-related molecules, our results imply MSCs bring additional complexity to MM populations with distinct stem cell-related properties.
IO biomarker
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CD38 (CD38 Molecule) • GSTP1 (Glutathione S-transferase pi 1) • SDC1 (Syndecan 1) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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GSTP1 overexpression • ABCB1 expression
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Revlimid (lenalidomide) • bortezomib • melphalan
22d
We analyzed cells at 72h of co-culture, MM cells (OPM-2, U266, AMO-1) with MSCs or treatments with cytostatics, bortezomib (BTZ), melphalan and lenalidomide. Further investigations will reveal behavior of MMs adhered to MSCs. Increased β-galactosidase activity and variable alkaline phosphatase activity in MSCs after co-culture suggests MM-MSC interactions may contribute to the senescent profile of MSC Conclusion Although MSCs and cytostatics might show similar effects in terms of contribution to the chemoresistance-related molecules, our results imply MSCs bring additional complexity to MM populations with distinct stem cell-related properties.
IO biomarker
|
ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CD38 (CD38 Molecule) • GSTP1 (Glutathione S-transferase pi 1) • SDC1 (Syndecan 1) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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GSTP1 overexpression • ABCB1 expression
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Revlimid (lenalidomide) • bortezomib • melphalan
22d
We analyzed cells at 72h of co-culture, MM cells (OPM-2, U266, AMO-1) with MSCs or treatments with cytostatics, bortezomib (BTZ), melphalan and lenalidomide. Further investigations will reveal behavior of MMs adhered to MSCs. Increased β-galactosidase activity and variable alkaline phosphatase activity in MSCs after co-culture suggests MM-MSC interactions may contribute to the senescent profile of MSC Conclusion Although MSCs and cytostatics might show similar effects in terms of contribution to the chemoresistance-related molecules, our results imply MSCs bring additional complexity to MM populations with distinct stem cell-related properties.
IO biomarker
|
ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CD38 (CD38 Molecule) • GSTP1 (Glutathione S-transferase pi 1) • SDC1 (Syndecan 1) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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GSTP1 overexpression • ABCB1 expression
|
Revlimid (lenalidomide) • bortezomib • melphalan
22d
We analyzed cells at 72h of co-culture, MM cells (OPM-2, U266, AMO-1) with MSCs or treatments with cytostatics, bortezomib (BTZ), melphalan and lenalidomide. Further investigations will reveal behavior of MMs adhered to MSCs. Increased β-galactosidase activity and variable alkaline phosphatase activity in MSCs after co-culture suggests MM-MSC interactions may contribute to the senescent profile of MSC Conclusion Although MSCs and cytostatics might show similar effects in terms of contribution to the chemoresistance-related molecules, our results imply MSCs bring additional complexity to MM populations with distinct stem cell-related properties.
IO biomarker
|
ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CD38 (CD38 Molecule) • GSTP1 (Glutathione S-transferase pi 1) • SDC1 (Syndecan 1) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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GSTP1 overexpression • ABCB1 expression
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Revlimid (lenalidomide) • bortezomib • melphalan
2ms
PCSK9 inhibited HCC cell proliferation, cell cycle progression, and apoptosis by interacting with GSTP1 and suppressing JNK signaling, suggesting that PCSK9 might act as a tumor suppressor and be a therapeutic target in HCC patients.
Journal
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PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) • GSTP1 (Glutathione S-transferase pi 1)
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GSTP1 overexpression
3ms
In conclusion, 2AAF induces the early appearance of HPC markers and as a result, accelerates the hepatocarcinogenesis induced by DEN in the rat. Thus, since 2AAF simultaneously administrated with DEN enriches HPC during hepatocarcinogenesis, we propose that DEN + 2AAF protocol might be a useful tool to investigate the cellular origin of HCC with progenitor features.
Preclinical • Journal
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GSTP1 (Glutathione S-transferase pi 1) • KRT19 (Keratin 19)
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GSTP1 overexpression
3ms
Preliminary findings for three SNPs rs2231142 (in ABCG2, ATP binding cassette subfamily G member 2), rs1800440 (in CYP1B1, Cytochrome P450 family 1 subfamily B member 1) and rs1695 (in GSTP1, Glutathione S-transferase pi 1) demonstrated genetic differences across the lines, based on either ethnicity of derivation (four African American-derived versus four Caucasian-derived), hormone receptor positivity (ER+/PR+/HER2+ versus ER+/PR+/HER2- versus ER-/PR-/HER2+) or triple-negative subtype (ER-/PR-/HER2-) classification. We are currently determining the targetable interactions between these SNPs and others with allelic differences, and metabolic responses to paclitaxel, which will enable us to test strategies for by-passing these impairments to improve treatment efficacy.
Clinical
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HER-2 (Human epidermal growth factor receptor 2) • ABCG2 • GSTP1 (Glutathione S-transferase pi 1)
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HER-2 negative • GSTP1 overexpression
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paclitaxel
4ms
, 95% CI = 0.36, 0.17-0.78, P for trend = 0.013; lipophilic ORAC = 0.58, 0.37-0.93, P for trend = 0.021; total phenolics = 0.38, 0.17-0.83, P for trend = 0.019). Our findings indicate that dietary ORAC intake may be inversely associated with the risk of gastric cancer altered by genetic variants of GSTP1, providing new intervention strategies for gastric cancer patients.
Clinical • Journal
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GSTP1 (Glutathione S-transferase pi 1)
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GSTP1 overexpression
5ms
TGF‑β‑induced oxidative stress was suppressed by increasing glutathione S‑transferase Pi 1 and reducing peroxiredoxin 1. Collectively, the present results indicated that AAV‑shRNAs were effective in modulating liver fibrosis by reducing oxidative stress, inflammation and activating the PPAR signaling pathway.
Journal
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GSTP1 (Glutathione S-transferase pi 1)
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GSTP1 overexpression
6ms
In silico analysis confirmed commonly deregulated proteins in the ventral prostate of old rats and patients with prostate cancer. In conclusion, the increase in oxidative stress associated with an imbalance of sex hormones may contribute to prostate carcinogenesis in offspring, highlighting early-life malnutrition as a key risk factor for this malignance.
Journal
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GSTP1 (Glutathione S-transferase pi 1)
|
GSTP1 overexpression
6ms
The results demonstrated that GSTP1 polymorphisms were useful predictors of severe events. Screening of single-nucleotide polymorphisms of GSTP1 in colorectal cancer patients before chemotherapy may help to realize personalized therapy.
Clinical • Journal
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GSTP1 (Glutathione S-transferase pi 1) • DPYD (Dihydropyrimidine Dehydrogenase)
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GSTP1 overexpression
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oxaliplatin
7ms
These outcomes demonstrate an eleven-gene molecular panel that predicts the patients' prospective survival following pancreatic resection for PDAC.
GSTP1 (Glutathione S-transferase pi 1) • MIR425 (MicroRNA 425) • CLIC6 (Chloride Intracellular Channel 6)
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GSTP1 overexpression
7ms
Moreover, GSTP1 overexpression was observed to reverse the effects of LINC01270 overexpression on EC cells and their response to 5-FU. Taken together, this study shows that inhibition of LINC01270 can lead to suppression of EC progression via demethylation of GSTP1, highlighting this lncRNA as a potential target for EC treatment.
Journal
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DNMT3A (DNA methyltransferase 1) • DNMT1 (DNA methyltransferase 1) • GSTP1 (Glutathione S-transferase pi 1) • DNMT3B (DNA Methyltransferase 3 Beta)
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GSTP1 overexpression
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fluorouracil topical
8ms
Thus, MNPC, a dual inhibitor for both NQO1 and GSTP1, provides a novel lead compound for treating GBM via the exploitation of specific vulnerabilities created by mutant EGFR.
Journal
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EGFR (Epidermal growth factor receptor) • GSTP1 (Glutathione S-transferase pi 1)
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EGFR mutation • EGFRvIII mutation • GSTP1 overexpression
9ms
Mutant GSTP1 genotype was an independent prognostic factor for increased HCC risk which can be used in a risk assessment model for HCC. Plasma GSH presents insufficient sensitivity and specificity for HCC.
Clinical • Journal
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GSTP1 (Glutathione S-transferase pi 1)
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GSTP1 overexpression
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