News - GSTP1 313A>G - LARVOL VERI

7ms

Effects of gene polymorphisms on delayed MTX clearance, toxicity, and metabolomic changes after HD-MTX treatment in children with acute lymphoblastic leukemia. (PubMed, Eur J Pediatr)

MTHFR 677C>T and ABCB1 3435 C>T predicted the risk of delayed MTX clearance during HD-MTX treatment in children with ALL. Serum L-phenylalanine levels were significantly elevated after HD-MTX treatment in children with the MTHFR 677C>T mutation gene.

7 months ago

Journal • Metabolomic study

ABCB1 (ATP Binding Cassette Subfamily B Member 1) • GSTP1 (Glutathione S-transferase pi 1) • MTHFR (Methylenetetrahydrofolate Reductase)

ABCB1 3435C>T • GSTP1 313A>G

methotrexate • methotrexate IV

7ms

Genetic variability in cisplatin metabolic pathways and outcome of locally advanced head and neck squamous cell carcinoma patients. (PubMed, Sci Rep)

Patients with FAS c.-671GG, GSTM1 present plus XPC c.2815AA, or plus XPD c.934GG, or plus XPD c.2251AA, or plus TP53 c.215GC or CC, and XPD c.2251AA plus XPF c.2505TT had up to 2.70 and 2.37 times more chances of presenting tumor progression and evolving to death, respectively. Our data indicate, for the first time, preliminary evidence that combined SNVs of CDDP metabolism act as independent prognostic factors and can be used to select patients for distinct treatments.

7 months ago

Journal • Metastases

TP53 (Tumor protein P53) • MLH1 (MutL homolog 1) • MSH2 (MutS Homolog 2) • ERCC1 (Excision repair cross-complementation group 1) • GSTP1 (Glutathione S-transferase pi 1) • FASLG (Fas ligand) • MSH3 (MutS Homolog 3) • CASP3 (Caspase 3) • XPC (XPC Complex Subunit, DNA Damage Recognition And Repair Factor) • GSTM1 (Glutathione S-transferase mu 1) • GSTT1 (Glutathione S-transferase theta 1)

GSTP1 313A>G

cisplatin

1year

Association of Clinical Aspects and Genetic Variants with the Severity of Cisplatin-Induced Ototoxicity in Head and Neck Squamous Cell Carcinoma: A Prospective Cohort Study. (PubMed, Cancers (Basel))

Our data present, for the first time, the association of combined inherited nucleotide variants involved in CDDP efflux, DNA repair, and apoptosis with ototoxicity, which could be potential predictors in future clinical and genomic models.

1 year ago

Journal

MLH1 (MutL homolog 1) • MSH2 (MutS Homolog 2) • ERCC1 (Excision repair cross-complementation group 1) • GSTP1 (Glutathione S-transferase pi 1) • FASLG (Fas ligand) • MSH3 (MutS Homolog 3) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • XPC (XPC Complex Subunit, DNA Damage Recognition And Repair Factor) • CASP9 (Caspase 9) • GSTM1 (Glutathione S-transferase mu 1) • GSTT1 (Glutathione S-transferase theta 1)

GSTP1 313A>G

cisplatin

over1year

Platinum-induced ototoxicity in pediatric cancer survivors: GSTP1 c.313A>G variant association. (PubMed, Medicine (Baltimore))

HL was not significantly associated with the total cumulative dose of cisplatin and carboplatin. GSTP1 c.313A>G variant may increase the risk of HL in pediatric oncology patients treated with cisplatin or carboplatin chemotherapy.

over 1 year ago

Journal

GSTP1 (Glutathione S-transferase pi 1)

GSTP1 313A>G

cisplatin • carboplatin