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    BIOMARKER:

    GSTM5 expression

    i
    Other names: GSTM5, Glutathione S-Transferase Mu 5, Glutathione S-Transferase M5, GST Class-Mu 5, GSTM5-5, Epididymis Secretory Sperm Binding Protein, S-(Hydroxyalkyl)Glutathione Lyase M5, Glutathione S-Aralkyltransferase M5, Glutathione S-Alkyltransferase M5, Glutathione S-Aryltransferase M5, GTM5
    Entrez ID:
    2949
    Related biomarkers:
    Expression
    Associations

    News

    Trials
    over3years
    Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis. (PubMed, BMC Cancer)
    Our data demonstrate that low GSTM5 expression and its high DNA methylation status may act as a novel putative molecular target gene for LUAD.
    Journal • Epigenetic controller
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    GSTM5 (Glutathione S-Transferase Mu 5)
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    GSTM5 expression
    over4years
    CircRNA_0084927 promotes colorectal cancer progression by regulating miRNA-20b-3p/glutathione S-transferase mu 5 axis. (PubMed, World J Gastroenterol)
    The expression of circ_0084927 is significantly increased in CRC and higher in advanced-stage CRC than in early-stage CRC. Moreover, circ_0084927 potentially regulates CRC cell migration and invasion via the miR-20b-3p/GSTM5/ AKT/mTOR pathway.
    Journal
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    GSTM5 (Glutathione S-Transferase Mu 5) • MIR20B (MicroRNA 20b)
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    GSTM5 expression
    almost5years
    Anti-Cancer Effects and Tumor Marker Role of Glutathione S-Transferase Mu 5 in Human Bladder Cancer. (PubMed, Int J Mol Sci)
    Though a degree of resistance to doxorubicin was noted in 5637 cells overexpressing GSTM5, no such resistance was observed in RT4 and BFTC 905 cells. In summary, GSTM5 plays a tumor suppressor role in bladder cancer cells without significantly affecting chemoresistance to cisplatin and mitomycin C, and the cellular GSH levels highlight a key mechanism underlying the cancer inhibition effect of GSTM5. These findings suggest that low gene expression and high DNA methylation levels of GSTM5 may act as tumor markers for bladder cancer.
    Journal
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    FN1 (Fibronectin 1) • GSTM5 (Glutathione S-Transferase Mu 5)
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    GSTM5 expression
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    cisplatin • doxorubicin hydrochloride