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    DRUG:

    GSK321

    i
    Other names: GSK321, GSK 321, GSK-321
    Company:
    GSK
    Drug class:
    IDH1 inhibitor
    Related drugs:
    5ms
    From Inhibitors to PET: SAR-Based Development of [18F]SK60 for mIDH1 Imaging. (PubMed, J Med Chem)
    In addition, limited brain uptake was observed by PET suggesting that further structural modifications to reduce lipophilicity might be needed for this structure. The present study led thus to a novel series of dimethylated GSK321 derivatives for further investigation in IDH1R132H-related therapies and PET imaging.
    Journal
    |
    IDH1 (Isocitrate dehydrogenase (NADP(+)) 1)
    |
    IDH1 mutation • IDH1 R132
    |
    GSK321