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    GENE:

    GRN (Granulin Precursor)

    i
    Other names: GRN, Granulin Precursor, PCDGF, PGRN, Progranulin, CLN11, PC Cell-Derived Growth Factor, Glycoprotein Of 88 Kda, Glycoprotein 88, Proepithelin, Acrogranin, GP88, PEPI, Epithelin Precursor, Granulin-Epithelin, Epithelin, Granulins, GEP
    Associations

    News

    Trials
    12d
    Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN) (clinicaltrials.gov)
    P1/2, N=35, Active, not recruiting, Prevail Therapeutics | Recruiting --> Active, not recruiting | Trial completion date: Apr 2031 --> Nov 2029 | Trial primary completion date: Apr 2031 --> Nov 2029
    Enrollment closed • Trial completion date • Trial primary completion date • First-in-human
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    GRN (Granulin Precursor)
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    prednisone • sirolimus
    1m
    ASPIRE-FTD: A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) (clinicaltrials.gov)
    P1/2, N=9, Recruiting, AviadoBio Ltd | Trial completion date: Oct 2030 --> Mar 2030
    Trial completion date
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    GRN (Granulin Precursor)
    1m
    A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN) (clinicaltrials.gov)
    P1/2, N=87, Active, not recruiting, Denali Therapeutics Inc. | Recruiting --> Active, not recruiting
    Enrollment closed
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    GRN (Granulin Precursor)
    2ms
    Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN) (clinicaltrials.gov)
    P1/2, N=35, Recruiting, Prevail Therapeutics | Trial primary completion date: Apr 2030 --> Apr 2031 | Trial completion date: Apr 2030 --> Apr 2031
    Trial completion date • Trial primary completion date
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    GRN (Granulin Precursor)
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    prednisone • sirolimus
    4ms
    Targeting Granulin Haploinsufficiency in Frontotemporal Dementia: From Genetic Mechanisms to Therapeutics. (PubMed, Int J Mol Sci)
    Improved models and refined delivery systems would be essential to develop safe and effective treatments. Future work should also focus on biomarker-guided interventions in presymptomatic mutation carriers.
    Review • Journal
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    TARDBP (TAR DNA Binding Protein) • GRN (Granulin Precursor)
    5ms
    A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN) (clinicaltrials.gov)
    P1/2, N=106, Recruiting, Denali Therapeutics Inc. | Trial completion date: Dec 2026 --> Nov 2028
    Trial completion date
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    GRN (Granulin Precursor)
    6ms
    A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN) (clinicaltrials.gov)
    P1/2, N=106, Recruiting, Denali Therapeutics Inc. | Trial completion date: Nov 2025 --> Dec 2026 | Trial primary completion date: Nov 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
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    GRN (Granulin Precursor)
    10ms
    Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells. (PubMed, Transl Neurodegener)
    Specifically, we characterize the phenotypes of lipid droplet-accumulating microglia and alterations of myelin lipid content resulting from lysosomal dysfunction caused by PGRN deficiency. Additionally, we consider how the deregulation of glia-neuron communication affects the exchange of organelles such as mitochondria, and the removal of excess toxic products such as protein aggregates, in PGRN-related neurodegeneration.
    Review • Journal
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    TARDBP (TAR DNA Binding Protein) • GRN (Granulin Precursor)
    11ms
    Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN) (clinicaltrials.gov)
    P1/2, N=30, Recruiting, Prevail Therapeutics | Trial completion date: Aug 2029 --> Apr 2030 | Trial primary completion date: Aug 2029 --> Apr 2030
    Trial completion date • Trial primary completion date
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    GRN (Granulin Precursor)
    |
    prednisone • sirolimus
    12ms
    Integrated multiomics analysis highlights the immunosuppressive role of granulin precursor positive macrophages in hepatocellular carcinoma. (PubMed, PeerJ)
    Functionally, GRN+ macrophages contacted with CD8+ T cells, which inducing T-cell exhaustion. Our study offers a comprehensive understanding of the clinical relevance and immunological role of GRN+ macrophages in HCC, indicating its potential role as a promising target for immunotherapeutic strategies.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • GRN (Granulin Precursor)
    1year
    Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer. (PubMed, J Hematol Oncol)
    Although SCLC initially responds to etoposide and platinum (EP) chemotherapy, nearly all patients relapse with resistant tumors...Targeted therapeutic strategies for GRN-low patients could improve outcomes, while new approaches are needed for GRN-high patients. Overall, our findings implicate GRN as a bridge between chemotherapy and immunotherapy resistance through GRN-mediated mechanisms.
    Journal • IO biomarker
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    GRN (Granulin Precursor)
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    etoposide IV
    1year
    Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurposing. (PubMed, Heliyon)
    Finally, overexpressed oncodriver genes guided top-ranked six drug agents (Irinotecan, Imatinib, etoposide, pazopanib, trametinib and cabozanitinib) were recommended against GBM through molecular docking study. Most of our findings received support by the literature review also. Therefore, the findings of this study might carry potential values to the wet-lab researchers for further investigation in terms of diagnosis and therapies of GBM.
    Journal
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    GRN (Granulin Precursor)
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    Mekinist (trametinib) • imatinib • pazopanib • etoposide IV • irinotecan