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    BIOMARKER:

    GRB7 overexpression

    i
    Other names: GRB7, Growth Factor Receptor Bound Protein 7, Growth Factor Receptor-Bound Protein 7, Epidermal Growth Factor Receptor GRB-7, GRB7 Adapter Protein, B47
    Entrez ID:
    2886
    Related biomarkers:
    Expression
    3ms
    GRB7-mediated enhancement of cell malignant characteristics induced by Helicobacter pylori infection. (PubMed, Front Microbiol)
    These results revealed GRB7-mediated pathogenesis in H. pylori infection, in which H. pylori activates STAT3, leading to increased GRB7 expression, then promotes activation of the ERK signal, and finally enhances malignant properties of infected cells. Our findings elucidate the role of GRB7 in H. pylori-induced gastric disorders, offering new prospects for the treatment and prevention of H. pylori-associated gastric carcinogenesis by targeting GRB7.
    Journal
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • GRB7 (Growth Factor Receptor Bound Protein 7)
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    GRB7 overexpression