GPR65 antagonist

DRUG CLASS:

GPR65 antagonist

News alerts, weekly reports and conference planners

2years

OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation. (PubMed, Int J Mol Sci)

The absence of OGR1 significantly alleviates the intestinal damage mediated by the lack of functional TDAG8. Both OGR1 and TDAG8 represent potential new targets for therapeutic intervention.

2 years ago

Journal

IFNG (Interferon, gamma) • IL10 (Interleukin 10) • IL23A (Interleukin 23 Subunit Alpha)

almost4years

Inhibition of GPR65 counteracts low pH induced immunosuppressive polarization of macrophages: In vitro and in vivo characterization of potent, selective and orally bioavailable small molecule GPR65 antagonists (AACR 2022)

Immunol. 19:1319

almost 4 years ago

Preclinical

CXCL10 (Chemokine (C-X-C motif) ligand 10) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • CXCL11 (C-X-C Motif Chemokine Ligand 11)