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    BIOMARKER:

    GPNMB overexpression

    i
    Other names: GPNMB, Glycoprotein Nmb, HGFIN, NMB, Hematopoietic Growth Factor Inducible Neurokinin-1 Type, Glycoprotein Nonmetastatic Melanoma Protein B, Glycoprotein (Transmembrane) Nmb, Transmembrane Glycoprotein NMB, Glycoprotein Nmb-Like Protein, Osteoactivin, Hematopoietic Growth Factor Inducible Neurokinin-1, Transmembrane Glycoprotein HGFIN, Transmembrane Glycoprotein, Glycoprotein NMB, PLCA3
    Entrez ID:
    10457
    Related biomarkers:
    Expression
    2ms
    Identification of GPNMB in endometrial cancer based on pan-cancer analysis and in vitro validation. (PubMed, Discov Oncol)
    Through pan-cancer analysis, we identified the antitumor effect of GPNMB in EC and predicted the potential mechanisms between GPNMB expression and EC.
    Preclinical • Journal • Pan tumor
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • GPNMB (Glycoprotein Nmb)
    |
    GPNMB expression • GPNMB overexpression
    8ms
    Glycoprotein nonmetastatic melanoma protein B impacts the malignant potential of bladder cancer cells through its hem-immunoreceptor tyrosine-based activation motif. (PubMed, Pathol Int)
    Therefore, we propose that GPNMB is one of multiple driver molecules in the acquisition of cellular migratory and invasive potential in bladder cancers. Moreover, we revealed that the tyrosine residue in the hemi-immunoreceptor tyrosine-based activation motif (hemITAM) is required for GPNMB-induced cellular motility.
    Journal • Metastases
    |
    GPNMB (Glycoprotein Nmb)
    |
    GPNMB expression • GPNMB overexpression
    9ms
    GPNMB Modulates Autophagy to Enhance Functional Recovery After Spinal Cord Injury in Rats. (PubMed, Cell Transplant)
    Inhibiting autophagy reversed the effects of GPNMB. These findings suggest that GPNMB promotes neural injury repair after SCI, potentially through attenuating the inflammatory response, reducing oxidative stress, and inhibiting cell apoptosis.
    Preclinical • Journal
    |
    GPNMB (Glycoprotein Nmb) • BECN1 (Beclin 1)
    |
    GPNMB expression • GPNMB overexpression