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    BIOMARKER:

    GPC1 expression

    i
    Other names: GPC1, Glypican 1, Epididymis secretory sperm binding protein, Glypican proteoglycan 1
    Entrez ID:
    2817
    Related biomarkers:
    Expression
    7ms
    Glypican-1-targeted antibody-drug conjugate inhibits the growth of glypican-1-positive glioblastoma. (PubMed, Neoplasia)
    In conclusion, GPC1-ADC demonstrated potent intracranial activity against GPC1-positive glioblastoma in an orthotopic xenograft model. These results indicate that GPC1-ADC could represent a groundbreaking new therapy for treating glioblastoma beyond the BBB.
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    GPC1 (Glypican 1)
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    GPC1 expression
    8ms
    Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for Pancreatic Cancer Diagnosis and Prognosis. (PubMed, Adv Sci (Weinh))
    Furthermore, among late-stage PDAC patients undergoing chemotherapy, lower GPC1 tMV-mProtein and Exo-mRNA expression before treatment correlated significantly with prolonged overall survival. These findings underscore the potential of vesicular GPC1 expression for early PDAC screenings and chemotherapy prognosis.
    Journal
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    GPC1 (Glypican 1)
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    GPC1 expression
    10ms
    A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma. (PubMed, J Transl Med)
    These results indicate that AT101, an IgM specific for an epitope of GPC1 close to PDAC cell surface, is a promising immunotherapeutic agent for GPC1-expressing PDAC, being able to selectively activate the complement system and recruit effector cells in the tumor microenvironment, thus allowing to reduce tumor mass growth and improve survival in treated mice.
    Journal
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    GPC1 (Glypican 1)
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    GPC1 expression