^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    GOT2 (Glutamic-Oxaloacetic Transaminase 2)

    i
    Other names: GOT2, Glutamic-Oxaloacetic Transaminase 2, KYAT4, Kynurenine Aminotransferase IV, MitAAT, KATIV, KAT4, Plasma Membrane-Associated Fatty Acid-Binding Protein, Glutamic-Oxaloacetic Transaminase 2, Mitochondrial, Aspartate Aminotransferase, Mitochondrial, Kynurenine--Oxoglutarate Transaminase IV, Kynurenine--Oxoglutarate Transaminase 4, Glutamate Oxaloacetate Transaminase 2, Kynurenine Aminotransferase 4, Aspartate Aminotransferase 2, Fatty Acid-Binding Protein, Aspartate Transaminase 2, Transaminase A, FABP-1, FABPpm, MAspAT, Glutamic-Oxaloacetic Transaminase 2, Mitochondrial (Aspartate Aminotransferase 2), DEE82
    Associations

    News

    Trials
    2years
    Surgical resection of lung cancer inhibits mRNA expression of GOT2 gene encoding kynurenine aminotransferase in leukocytes. (PubMed, Ann Agric Environ Med)
    Surgical resection of lung cancer results in inhibition of GOT2 mRNA expression in leukocytes. Further studies are expected to show whether it may be used as a target point for personalized therapies in lung cancer.
    Journal
    |
    GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • GOT2 (Glutamic-Oxaloacetic Transaminase 2)
    over2years
    Combining single-cell and transcriptomic analysis revealed the immunomodulatory effect of GOT2 on a glutamine-dependent manner in cutaneous melanoma. (PubMed, Front Pharmacol)
    We verified its role in promoting tumor cell proliferation by CCK-8 and clone formation assays. Our study cast new light on the prognosis of cutaneous melanoma, and the internal mechanism regulating glutamine metabolism of GOT2 may provide a new avenue for treating the cutaneous melanoma disease precisely.
    Journal • Immunomodulating
    |
    GOT2 (Glutamic-Oxaloacetic Transaminase 2)