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    BIOMARKER:

    GOLM1 overexpression

    i
    Other names: GOLM1, Golgi Membrane Protein 1, Golgi Phosphoprotein 2, BA379P1.3, C9orf155, GOLPH2, GP73, Golgi Membrane Protein GP73, FLJ23608, Chromosome 9 Open Reading Frame 155, Epididymis Luminal Protein 46, Golgi Protein, 73-KD, PSEC0257, HEL46
    Entrez ID:
    51280
    1year
    GOLM1 facilitates human colorectal cancer progression and metastasis via activating the AKT/GSK3β/EMT axis. (PubMed, Neoplasma)
    Finally, MK2206, an AKT inhibitor, could markedly reverse GOLM1-elicited proliferation, migration, invasion, and EMT phenotype by inhibiting the AKT/GSK3β pathway. Collectively, our data indicate that GOLM1 facilitates human CRC progression and metastasis via activating the AKT/GSK3β/EMT axis. Most importantly, our study makes substantial support for the clinical translation of GOLM1 in CRC target therapy.
    Journal
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    GOLM1 (Golgi Membrane Protein 1) • GSK3B (Glycogen Synthase Kinase 3 Beta)
    |
    GOLM1 overexpression
    |
    MK-2206