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    GENE:

    GNLY (Granulysin)

    i
    Other names: GNLY, Granulysin, TLA519, NKG5, D2S69E, LAG-2, LAG2, T-Lymphocyte Activation Gene 519, T-Cell Activation Protein 519, Lymphokine LAG-2, Lymphocyte-Activation Gene 2, Protein NKG5
    Associations

    News

    Trials
    10d
    SAPCD2 Drives Bladder Cancer Progression by Stabilizing TANK and Engaging a CREB-PLAGL2 Feedback Loop to Sustain MAPK Signaling. (PubMed, Cancers (Basel))
    This study indicated that SAPCD2 could serve as a critical driver of BCa malignancy, emphasizing its role in sustaining oncogenic signaling through the SAPCD2-TANK-MAPK axis and the PLAGL2-SAPCD2-CREB feedback loop. Targeting this pathway may offer novel therapeutic strategies for treating aggressive BCa.
    Journal
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    GNLY (Granulysin) • PLAGL2 (PLAG1 Like Zinc Finger 2)
    3ms
    Discovery of novel small molecule inhibitor targeting the tumor promoting effect of transcription factor PLAGL2. (PubMed, Eur J Med Chem)
    It effectively inhibited tumor growth in HCCLM3 xenograft tumor models while demonstrating a favorable safety profile. Taken together, this study introduces a promising 3-(Phenylsulfonamido) benzamide derivative as a novel approach to targeting PLAGL2 transcriptional activity, laying a foundation for future investigations in anti-tumor therapy.
    Journal
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    GNLY (Granulysin) • PLAGL2 (PLAG1 Like Zinc Finger 2)
    3ms
    Serum p-Cresol and 7-HOCA Levels and Fatty Acid and Purine Metabolism Are Associated with Survival, Progression, and Molecular Classification in GB-Serum Proteome and Metabolome Analysis Pre vs. Post Up-Front Chemoirradiation. (PubMed, Curr Oncol)
    Serum-based fatty acid and purine metabolism pathways are associated with OS and PFS in GB. 7-HOCA and p-cresol emerged as potential biomarkers linked to treatment response and molecular subtype. These findings support further investigation of noninvasive biospecimens for clinically actionable biomarkers in GB.
    Journal
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    MGMT (6-O-methylguanine-DNA methyltransferase) • ATG5 (Autophagy Related 5) • PLAG1 (PLAG1 Zinc Finger) • GNLY (Granulysin)
    7ms
    A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AML. (PubMed, J Transl Med)
    This multi-omics study provides unprecedented insights into the transcriptional and epigenetic heterogeneity of t(8;21) AML, providing a potential actionable tool for clinical risk stratification.
    Journal
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    GZMB (Granzyme B) • TPSAB1 (Tryptase Alpha/Beta 1) • GNLY (Granulysin) • NKG7 (Natural Killer Cell Granule Protein 7) • TCF12 (Transcription Factor 12)
    7ms
    PLAGL2 as a prognostic biomarker and an EMT-promoting factor in PDAC. (PubMed, Sci Rep)
    This study demonstrated that the expression level of PLAGL2 serves as a predictive biomarker for survival in patients with pancreatic ductal adenocarcinoma (PDAC). It is associated with clinical features, including TNM stge, Tumor size, Nerve infiltration, and it also plays a role in promoting epithelial‒mesenchymal transition (EMT) in PDAC, and promotes the proliferation, migration and invasion of PDAC.
    Journal
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    GNLY (Granulysin) • PLAGL2 (PLAG1 Like Zinc Finger 2)
    1year
    Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner. (PubMed, Biol Direct)
    METTL7B is involved in BC development and progression. METTL7B may mediate m6A modification on ACSL3 mRNA to negatively regulate ferroptosis in BC cells, which provides a potential therapeutic target for BC via ferroptosis.
    Journal
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    CCND1 (Cyclin D1) • CDK4 (Cyclin-dependent kinase 4) • CDK6 (Cyclin-dependent kinase 6) • ACSL3 (Acyl-CoA Synthetase Long Chain Family Member 3) • FANCD2 (FA Complementation Group D2) • CDKN2D (Cyclin Dependent Kinase Inhibitor 2D) • FADS2 (Fatty Acid Desaturase 2) • GNLY (Granulysin) • PLAGL2 (PLAG1 Like Zinc Finger 2)
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    erastin
    over1year
    A Novel CRISPR/Cas9-mediated mouse model of colon carcinogenesis. (PubMed, Cell Mol Gastroenterol Hepatol)
    This conditional model represents a new CRISPR/Cas9-mediated mouse model of colorectal carcinogenesis. These mice can be used to investigate the role of novel, previously uncharacterized genes in CRC, in the context of multiple commonly mutated tumor suppressor genes and thus more closely mimic human CRC pathogenesis.
    Preclinical • Journal
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    TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • SMAD4 (SMAD family member 4) • GNLY (Granulysin) • PLAGL2 (PLAG1 Like Zinc Finger 2)
    over1year
    Unraveling clonal CD8 T cell expansion and identification of essential factors in γ-herpesvirus-induced lymphomagenesis. (PubMed, Proc Natl Acad Sci U S A)
    Finally, while AlHV-1 mutants expressing mutated forms of A10 devoid of ITAM or SH3 motifs (or both) were able to induce MCF, a recombinant virus expressing a mutated form of A10 unable to phosphorylate its tyrosine residues resulted in the lack of MCF and protected against a wild-type virus challenge. Thus, we could characterize the nature of this γ-herpesvirus-induced PTCL-like disease and identify an essential mechanism explaining its development.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • GZMA (Granzyme A) • GNLY (Granulysin)
    almost2years
    Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop. (PubMed, Exp Mol Med)
    Taken together, these results reveal that stress-induced epinephrine activates the PLAGL2-USP10 signaling loop to enhance HCC progression. Furthermore, PLAGL2 plays a crucial role in psychological stress-mediated promotion of HCC progression.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • ADRB2 (Adrenoceptor Beta 2) • GNLY (Granulysin) • PLAGL2 (PLAG1 Like Zinc Finger 2)
    2years
    Inhibiting the mA Reader IGF2BP3 Suppresses Ovarian Cancer Cell Growth via Regulating PLAGL2 mRNA Stabilization. (PubMed, World J Oncol)
    Further, in in vivo experiments, IGF2BP3 knockdown suppressed ovarian cancer cell proliferation via inhibiting PLAGL2 expression. All of these indicate that PLAGL2 mediates the main function of IGF2BP3 knockdown on ovarian cancer proliferation inhibition through mRNA stability regulation.
    Journal
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    IGF2 (Insulin-like growth factor 2) • PLAG1 (PLAG1 Zinc Finger) • GNLY (Granulysin) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) • PLAGL2 (PLAG1 Like Zinc Finger 2)
    over2years
    A comprehensive analysis of infantile central nervous system tumors to improve distinctive criteria for infant-type hemispheric glioma versus desmoplastic infantile ganglioglioma/astrocytoma. (PubMed, Brain Pathol)
    Moreover, these results are consistent with the literature data concerning the molecular dichotomy (BRAF/RAF1 alterations vs. RTK genes' fusions) between DIG/DIA and IHG. This study characterized histopathologically and radiologically two additional cases of the novel embryonal tumor characterized by PLAGL2 gene amplification.
    Journal
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    BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase) • YAP1 (Yes associated protein 1) • GNLY (Granulysin) • ZFTA (Zinc Finger Translocation Associated) • PLAGL2 (PLAG1 Like Zinc Finger 2)
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    NTRK1 fusion • NTRK2 fusion • ALK fusion • ROS1 fusion
    over2years
    PLAGL2 promotes bladder cancer progression via RACGAP1/RhoA GTPase/YAP1 signaling. (PubMed, Cell Death Dis)
    Importantly, the RhoA inhibitor simvastatin or the YAP1/TAZ inhibitor verteporfin abrogated the proproliferative and prometastatic effects of BCa enhanced by PLAGL2. These findings suggest that PLAGL2 promotes BCa progression via RACGAP1/RhoA GTPase/YAP1 signaling. Hence, the core nodes of signaling may be promising therapeutic targets for BCa.
    Journal
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    YAP1 (Yes associated protein 1) • RHOA (Ras homolog family member A) • GNLY (Granulysin) • RACGAP1 (Rac GTPase activating protein 1)
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    Visudyne (verteporfin) • simvastatin