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    BIOMARKER:

    GLUL overexpression

    i
    Other names: GLUL, Glutamate-Ammonia Ligase, Glutamine Synthetase, Palmitoyltransferase GLUL, GLNS, Glutamate-Ammonia Ligase (Glutamine Synthase, Cell Proliferation-Inducing Protein 59, Proliferation-Inducing Protein 43 ,Glutamate—Ammonia Ligase, Glutamate Decarboxylase, Glutamine Synthase, PIG43, PIG59
    Entrez ID:
    2752
    Associations

    News

    Trials
    almost4years
    Genomic alterations drive metastases formation in pancreatic ductal adenocarcinoma cancer: deciphering the role of CDKN2A and CDKN2B in mediating liver tropism. (PubMed, Oncogene)
    Further studies indicated a unique role for p15/16 in regulating glutaminolysis. These findings reveal vulnerabilities in PDAC cells, which may pave the way for the development of novel therapeutic strategies aiming at the prevention of liver metastases formation.
    Journal
    |
    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • GLUL (Glutamate-Ammonia Ligase)
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    CDKN2A deletion • GLUL overexpression
    over4years
    Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival. (PubMed, J Cancer Res Clin Oncol)
    Growth inhibition resulting from glutamine depletion, as described for the hepatoblastoma fetal subtype, is also detected in established embryonal hepatoblastoma cell lines carrying different mutations. At variance with adult hepatocellular carcinoma, in hepatoblastoma asparagine synthetase has no prognostic significance.
    Clinical • Journal
    |
    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • ASNS (Asparagine synthetase) • GLUL (Glutamate-Ammonia Ligase)
    |
    CTNNB1 mutation • GLUL overexpression