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DRUG:

Sitoiganap (ERC1671)

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Other names: ERC1671, ERC-1671, ERC 1671
Company:
Epitopoietic Research Corp
Drug class:
Immunostimulant
Related drugs:
over2years
A Prospective, Cohort Study of SITOIGANAP to Treat Glioblastoma When Given in Combination With Granulocyte-Macrophage Colony-Stimulating Factor/Cyclophosphamide/Bevacizumab/Nivolumab or Granulocyte-Macrophage Colony-Stimulating Factor/Cyclophosphamide/Bevacizumab/Pembrolizumab in Patients Who Failed Prior Treatment With Surgical Resection, Radiation, and Temozolomide. (PubMed, Front Oncol)
The enrollment and end-of-study CD3/CD4 T-lymphocyte counts strongly correlate with OS. The addition of SITOIGANAP/GM-CSF/cyclophosphamide to bevacizumab and an anti-PD-1 monoclonal antibody resulted in a significant survival benefit compared to historic control values in rGBM with minimal toxicity compared to current therapy.
Journal • Combination therapy
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CD4 (CD4 Molecule) • CSF2 (Colony stimulating factor 2)
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Keytruda (pembrolizumab) • Opdivo (nivolumab) • Avastin (bevacizumab) • temozolomide • cyclophosphamide • Sitoiganap (ERC1671)
over2years
New P2 trial • Combination therapy
|
CD4 (CD4 Molecule)
|
Keytruda (pembrolizumab) • Avastin (bevacizumab) • temozolomide • cyclophosphamide • Sitoiganap (ERC1671)
over3years
ERC1671/GM-CSF/Cyclophosphamide for the Treatment of Glioblastoma Multiforme (clinicaltrials.gov)
P2, N=84, Active, not recruiting, University of California, Irvine | Recruiting --> Active, not recruiting
Clinical • Enrollment closed
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IL6 (Interleukin 6) • IL2RA (Interleukin 2 receptor, alpha) • CD4 (CD4 Molecule) • IL10 (Interleukin 10) • CSF2 (Colony stimulating factor 2)
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Avastin (bevacizumab) • cyclophosphamide • Sitoiganap (ERC1671) • Leukine (sargramostim) • cyclophosphamide intravenous