Glioblastoma

P=N/A, N=70, Active, not recruiting, Sunnybrook Health Sciences Centre | Recruiting --> Active, not recruiting

These findings suggest that HK2KD is associated with transcriptional changes extending beyond glycolytic pathways, linking metabolic activity to immunological and angiogenic transcriptional networks in a model-dependent manner. Although functional effects on the tumour microenvironment were not directly assessed, this study provides a transcriptomic framework for understanding how HK2 targeting may be associated with changes in tumour-associated signalling pathways, with potential implications for stratified metabolic and combination therapeutic strategies in glioblastoma.

Nanopore sequencing enables rapid, accurate, multidimensional molecular classification of diagnostically intractable CNS tumors using routine FFPE and frozen tissue, achieving high diagnostic resolution in comparison with reference methods while drastically reducing turnaround time and cost, making precision neuropathology feasible beyond quaternary centers.

These suggest that only βCD increases NRF2 and ROS as an adaptive response of A172 cells. The incorporation of amphiphilic dendritic groups enables efficient cellular uptake of βCD-dendronized containers.

P3, N=450, Active, not recruiting, Ivy Brain Tumor Center | Recruiting --> Active, not recruiting

P=N/A, N=9, Not yet recruiting, Huanhu Hospital Affiliated to Tianjin Medical University

Proteomics analysis revealed a strategic mechanism to resist TMZ-induced apoptosis by upregulating exosomal proteins associated with biogenesis, chemoresistance, and therapeutic adaption. This finding revealed a considerable TMZ resistance mechanism and provided a new inspiration for preventing exosome biogenesis to resensitise TMZ cytotoxicity towards GBM.

Drug testing with temozolomide (TMZ) demonstrated reduced sensitivity under hypoxic conditions, shown by a 56% increase in IC50, reflecting clinically relevant therapy resistance. These findings show the ability of the model to mimic key properties of the GBM microenvironment at both phenotypic and molecular levels and offer a physiologically relevant platform to study GBM biology and evaluate therapeutic responses.

It delves into its regulation of core cellular processes, its integration into oncogenic signaling networks, and its recently discovered functions in epigenetic and metabolic reprogramming. By consolidating this knowledge, we aim to highlight the multifaceted nature of DHX33 in cancer biology and firmly establish its potential as a viable and promising therapeutic target for future anticancer strategies.

Doxorubicin (DOX) was efficiently encapsulated via temperature-controlled loading to obtain DOX@FTn-EGFRAfb with high protein recovery, pH-responsive drug release, and strong stability...In an orthotopic U87 glioma mouse model, DOX@FTn-EGFRAfb significantly inhibited tumor growth and prolonged survival without obvious systemic toxicity. This work presents a versatile protein-engineering strategy for dual-targeted glioblastoma drug delivery.

The study demonstrates that combined ADC and plasma PGF showed a similar predictive value in recurrent GB after standard treatment as combined ADC, plasma PGF and GFAP together. Considering limited sample size and lack of more sample types in this study, additional value of plasma GFAP in predicting recurrent GB should be further investigated in larger-scale population or different sample sources.

These findings will not only aid in understanding the mechanisms by which EV71 infection impacts the host immune system but also provide a scientific basis for identifying early diagnostic biomarkers and developing new therapeutic strategies.