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BIOMARKER:

GLI1 overexpression

i
Other names: GLI1, GLI Family Zinc Finger 1, Glioma-Associated Oncogene Homolog 1 (Zinc Finger Protein), Zinc Finger Protein GLI1, Oncogene GLI, GLI, Glioma-Associated Oncogene Family Zinc Finger 1, GLI-Kruppel Family Member GLI1, Glioma-Associated Oncogene 1, Glioma-Associated Oncogene , PAPA8, PPD1
Entrez ID:
Related biomarkers:
29d
Gli1-mediated tumor cell-derived bFGF promotes tumor angiogenesis and pericyte coverage in non-small cell lung cancer. (PubMed, J Exp Clin Cancer Res)
The Gli1-bFGF axis is crucial for the crosstalk between lung cancer cells and vascular cells. Targeting Gli1 is a potential therapeutic approach for NSCLC angiogenesis.
Journal • Tumor cell
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GLI1 (GLI Family Zinc Finger 1)
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GLI1 overexpression • GLI1 expression
2ms
En1 promotes cell proliferation and migration via Hedgehog signaling pathway in esophageal squamous cell carcinoma (PubMed, Zhonghua Zhong Liu Za Zhi)
In clinical samples of ESCC, major regulatory factors of the Hedgehog pathway were up-regulated and the pathway was activated. En1 promotes the proliferation and migration of ESCC cells by regulating the Hedgehog pathway and can be used as a new potential target for targeted therapy of ESCC.
Journal
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GLI2 (GLI Family Zinc Finger 2)
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GLI1 overexpression • GLI1 expression
5ms
Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis. (PubMed, J Exp Clin Cancer Res)
Hedgehog-Gli1-induced exosomal circ-0011536 promoted PNR via the miR-451a/VGF axis, thereby establishing that it may contribute to PDAC-associated nerve changes with activated Hedgehog signaling.
Journal
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GLI1 (GLI Family Zinc Finger 1) • MIR451A (MicroRNA 451a)
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GLI1 overexpression • GLI1 expression
5ms
Journal
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GLI1 (GLI Family Zinc Finger 1)
|
GLI1 overexpression • GLI1 expression
7ms
Transcription Factor GLI1 Induces IL-6-Mediated Inflammatory Response and Facilitates the Progression of Adamantinomatous Craniopharyngioma. (PubMed, ACS Chem Neurosci)
Conversely, GLI1 knockdown markedly suppressed these processes. Our study uncovers a potential molecular mechanism for the occurrence of inflammatory responses and tumor progression in ACP.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • GLI1 (GLI Family Zinc Finger 1) • IL1B (Interleukin 1, beta)
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GLI1 overexpression • IL6 expression
9ms
Targeting the Hedgehog pathway with novel Gli1 hydrophobic tagging degraders. (PubMed, Bioorg Chem)
Compared to the canonical Hh antagonist Vismodegib, 8e exhibited much stronger potency in suppressing the mRNA expression of Hh target genes in Hh-overactivated MEF and Vismodegib resistant MEF cells. Our study provides small molecule Gli1 degraders effectively interfering with both canonical and noncanonical Hh signaling and overcoming current Smoothened (SMO) antagonists resistance, which might pave a new avenue for developing therapeutic modalities targeting Hh/Gli1 signaling pathway.
Journal
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GLI1 (GLI Family Zinc Finger 1)
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GLI1 overexpression
|
Erivedge (vismodegib)
10ms
Zinc finger and SCAN domain-containing 18 suppresses the proliferation, self-renewal, and drug resistance of glioblastoma cells. (PubMed, Heliyon)
ZSCAN18 overexpression enhanced the sensitivity of glioblastoma cells to Temozolomide...Taken together, this research uncovers the role of ZSCAN18 in regulating glioblastoma cell growth and maintenance. ZSCAN18 could be a potential glioblastoma biomarker.
Journal
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GLI1 (GLI Family Zinc Finger 1) • SOX2 • POU5F1 (POU Class 5 Homeobox 1)
|
GLI1 overexpression • SOX2 expression • POU5F1 expression
|
temozolomide
10ms
LINC00641 impeded the malignant biological behaviors of papillary thyroid carcinoma cells via interacting with IGF2BP1 to reduce GLI1 mRNA stability. (PubMed, Hum Exp Toxicol)
Finally, in vivo experimental results showed that overexpression of LINC00641 markedly suppressed tumor growth and reduced expression of GLI1 and p-AKT in xenograft tumor mice(p < 0.05). In summary, this study highlighted that LINC00641 plays a critical role in the malignant biological progression of PTC by regulating the LINC00641/IGF2BP1/GLI1/AKT signaling pathway, which may serve as a potential therapeutic target for PTC.
Journal
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GLI1 (GLI Family Zinc Finger 1) • IGF2 (Insulin-like growth factor 2) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1)
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GLI1 overexpression • GLI1 expression
10ms
High GLI-1 Expression is a Reliable Indicator of Bad Prognosis in Newly Diagnosed Acute Leukemia Patients. (PubMed, Indian J Hematol Blood Transfus)
GLI-1 overexpression is a risk factor for poor prognosis and could be a novel therapeutic target for AML.
Journal
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FLT3 (Fms-related tyrosine kinase 3)
|
GLI1 overexpression
1year
GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration. (PubMed, Biochem J)
Finally, we show that the integrity of two GLI binding sites in the SDF1 promoter is required for p300 recruitment. Our findings define a new role for the p300-GLI1 complex in the regulation of SDF1, providing new mechanistic insight into the molecular events controlling pancreatic cancer cells migration.
Journal
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CXCL12 (C-X-C Motif Chemokine Ligand 12) • GLI1 (GLI Family Zinc Finger 1)
|
GLI1 overexpression • GLI1 expression
over1year
SOX2-OT/SOX2 axis regulates lung cancer H520 cell migration via Gli1-mediated epithelial-mesenchymal transition (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)
The SOX2-OT/SOX2 axis positively regulates migration of lung squamous H520 cells via Gli1-mediated EMT.
Journal
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GLI1 (GLI Family Zinc Finger 1) • SOX2 • MIR200C (MicroRNA 200c)
|
GLI1 overexpression • GLI1 expression
over1year
Expression of Hedgehog Signaling Pathway Proteins in Basal Cell Carcinoma: Clinicopathologic Study. (PubMed, Clin Cosmet Investig Dermatol)
Our study suggests that UV radiation may be associated with aberrant activation of the Hh-PTCH1-Gli1 intercellular signaling pathway in BCC. The molecular mechanism of UV-related PTCH1 and Gli1 differential expression deserves more rigorous research in the future.
Journal
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PTCH1 (Patched 1)
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GLI1 overexpression • GLI1 expression
over1year
Gli1 promotes epithelial-mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability. (PubMed, Acta Pharm Sin B)
In addition, administration of GANT-61, a Gli1 inhibitor, obviously suppressed the metastasis of NSCLC. Collectively, our study reveals that Gli1 is a critical regulator for NSCLC metastasis and suggests that targeting Gli1 is a prospective therapy strategy for metastatic NSCLC.
Journal
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GLI1 (GLI Family Zinc Finger 1) • SNAI1 (Snail Family Transcriptional Repressor 1)
|
GLI1 overexpression • GLI1 expression
over1year
RNA-seq and ChIP-seq Identification of Unique and Overlapping Targets of GLI Transcription Factors in Melanoma Cell Lines. (PubMed, Cancers (Basel))
Our study provides insight into the unique and overlapping transcriptional output of the GLI proteins in melanoma. We suggest that our findings could provide new potential targets to consider while designing melanoma-targeted therapy.
Preclinical • Journal
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GLI1 (GLI Family Zinc Finger 1) • GLI3 (GLI Family Zinc Finger 3) • GLI2 (GLI Family Zinc Finger 2)
|
GLI1 overexpression • GLI1 expression • GLI2 overexpression
over1year
A Sonic Hedgehog Pathway Score to Predict the Outcome of Resected Non-Small Cell Lung Cancer Patients. (PubMed, Ann Surg Oncol)
Our results provide relevant prognostic data for NSCLC patients and support further studies on the Hh pathway.
Journal
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PTCH1 (Patched 1) • GLI1 (GLI Family Zinc Finger 1)
|
GLI1 overexpression • GLI1 expression
over1year
Glycolytic Metabolic Remodeling by the Truncate of Glioma-Associated Oncogene Homolog 1 in Triple-Negative Breast Cancer Cells. (PubMed, J Cancer)
Moreover, metabolic stress after GLI1 knockdown activated the energy sensor, adenosine monophosphate-activated protein kinase, which subsequently resulted in autophagy induction. In conclusion, this study indicates that targeting GLI1 reprograms the tumor glucose metabolism to suppress breast cancer cell growth and proliferation.
Journal
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GLI1 (GLI Family Zinc Finger 1)
|
GLI1 overexpression • GLI1 expression
almost2years
RNA sequencing reveals unique and overlapping transcriptional targets of GLI1; GLI2 and GLI3 in melanoma cell lines (EACR 2022)
Majority of the genes are overlapping targets of GLI1 and GLI2; which was expected, while GLI3 regulates a small number of separate gene targets. Conclusion In this study we have identified unique and overlapping targets of GLI1; GLI2 and GLI3 in melanoma cell lines and confirmed 12 of them by qPCR on an expanded set of melanoma cell lines, suggesting these genes are novel targets of HH-GLI signaling in melanoma.
Preclinical
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PTCH1 (Patched 1) • GLI1 (GLI Family Zinc Finger 1) • GLI3 (GLI Family Zinc Finger 3) • GLI2 (GLI Family Zinc Finger 2)
|
GLI1 overexpression • GLI1 expression • GLI3 expression
almost2years
High GLI-1 expression predicts poor prognosis in AML patients (BSH 2022)
GLI overexpression can be considered as a negative prognostic factor in AML. In addition, it may offer a novel target for therapy in AML patients in near future. Key words: AML, Gli1, poor prognosis.
Clinical
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FLT3 (Fms-related tyrosine kinase 3) • GLI1 (GLI Family Zinc Finger 1)
|
GLI1 overexpression • GLI1 expression
2years
Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer. (PubMed, Eur J Cancer)
MEOX2/GLI1 promote resistance to cisplatin and EGFR-TKI-based therapy in lung cancer cells, modulating EGFR/AKT/ERK signalling pathway activation, as well as inducing an aberrant epigenetic modulation of the EGFR-gene expression in human lung cancer.
Journal
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EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • GLI1 (GLI Family Zinc Finger 1) • MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1)
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KRAS mutation • EGFR mutation • EGFR wild-type • EGFR overexpression • KRAS wild-type • GLI1 overexpression • GLI1 expression
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cisplatin • Tagrisso (osimertinib) • erlotinib • Koselugo (selumetinib)
over2years
Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling. (PubMed, Phytomedicine)
We provided evidence that RA restrained the nuclear translocation of Gli1 and facilitates Gli1 degradation via proteasome pathway, reducing the malignancy of PDAC cells. These findings implicated RA as a therapeutic agent for PDAC.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • GLI1 (GLI Family Zinc Finger 1) • BAX (BCL2-associated X protein) • CDK2 (Cyclin-dependent kinase 2) • MMP9 (Matrix metallopeptidase 9) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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CDH1 expression • GLI1 overexpression • BAX expression • CDK2 expression • CDKN1B expression
over2years
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone provokes progression from chronic pancreatitis to pancreatic intraepithelial neoplasia. (PubMed, iScience)
We demonstrate that NNK promotes acinar-to-ductal metastasis and pancreatic intraepithelial neoplasia in rats with chronic pancreatitis, accompanied by desmoplastic reaction and Gli1 overexpression. Together, we here present evidence that NNK provokes the progression of chronic pancreatitis toward pancreatic cancer and highlight potential strategies and targets for early prevention of pancreatic cancer and its therapeutics.
Journal
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KRAS (KRAS proto-oncogene GTPase) • GLI1 (GLI Family Zinc Finger 1)
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KRAS mutation • GLI1 overexpression
over2years
Curcumin inhibits the invasion and metastasis of triple negative breast cancer via Hedgehog/Gli1 signaling pathway. (PubMed, J Ethnopharmacol)
Curcumin can inhibit the proliferation and metastasis of TNBC cells, EMT and characteristics of BCSC by Hedgehog/Gli1 pathway.
Journal
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GLI1 (GLI Family Zinc Finger 1) • VIM (Vimentin)
|
GLI1 overexpression • GLI1 expression
over2years
RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway. (PubMed, Life Sci)
Finally, RSPO2 depletion was impaired NPC tumor growth in vivo animal experiments. In conclusion, the present study confirmed that RSPO2 silence inhibits the tumorigenesis of NPC via ZNRF3/Hedgehog-Gli1 signal pathway.
Journal
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CDH1 (Cadherin 1) • GLI1 (GLI Family Zinc Finger 1) • VIM (Vimentin) • RSPO2 (R-Spondin 2)
|
CDH1 expression • GLI1 overexpression • GLI1 expression • VIM expression
almost3years
Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells. (PubMed, Cell Death Dis)
Our recent study showed that the inhibitors of the Shh pathway such as cyclopamine (CP), a Smothened (SMO) inhibitor, and GANT61, a Gli1 inhibitor, have modest inhibitory effects on thyroid tumor cell proliferation and tumor growth...GANT61-induced autophagy was blocked by TAK1 siRNA and the inhibitors of TAK1 (5Z-7-oxozeaenol, 5Z), JNK (SP600125), and AMPK (Compound C, CC). Inhibition of autophagy by chloroquine and 5Z and by TAK1 and Beclin-1 siRNA enhanced GANT61-induced apoptosis and its antiproliferative activity. Our study has shown that inhibition of the Shh pathway induces autophagy by activating TAK1, whereas autophagy in turn suppresses GANT61-induced apoptosis. We have uncovered a previously unrecognized role of TAK1 in Shh pathway inhibition-induced autophagy and apoptosis.
Journal
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GLI1 (GLI Family Zinc Finger 1) • TGFB1 (Transforming Growth Factor Beta 1) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) • BECN1 (Beclin 1)
|
GLI1 overexpression
|
cyclopamine • SP600125 • chloroquine phosphate
almost3years
Smoothened loss is a characteristic of neuroendocrine prostate cancer. (PubMed, Prostate)
These results demonstrate that SMO loss is a characteristic of NEPC and that detecting SMO by IHC could aid pathologists in NEPC diagnosis. SMO loss may promote NEPC pathogenesis by modulating AR signaling.
Journal
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AR (Androgen receptor) • GLI1 (GLI Family Zinc Finger 1) • KLK3 (Kallikrein-related peptidase 3)
|
AR expression • GLI1 overexpression • GLI1 expression
3years
GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia. (PubMed, Cell Death Dis)
Notably, the GLI1 inhibitor GANT61 and the CDK4/6 inhibitor PD 0332991 had synergistic effects in promoting Ara-c sensitivity in AML cell lines and patient samples. Collectively, our data demonstrate that GLI1 reduces drug sensitivity by regulating cell cycle through the PI3K/AKT/GSK3/CDK pathway, providing a new perspective for involving GLI1 and CDK4/6 inhibitors in relapsed/refractory (RR) patient treatment.
Journal
|
PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • GLI1 (GLI Family Zinc Finger 1) • CCND3 (Cyclin D3)
|
GLI1 overexpression • GLI1 expression
|
Ibrance (palbociclib) • cytarabine
3years
Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade. (PubMed, Cell Death Differ)
Moreover, IHC results showed that MVP, GLI1, and P-p70S6K1 were highly expressed and positively correlated with each other in 71 human CS tissues. Overall, our findings revealed a novel regulating mechanism for HH-independent GLI1 expression and provide a rationale for combination therapy in patients with advanced CS.
Journal
|
GLI1 (GLI Family Zinc Finger 1) • SUFU (SUFU Negative Regulator Of Hedgehog Signaling)
|
GLI1 overexpression • GLI1 expression
3years
Journal
|
GLI1 (GLI Family Zinc Finger 1) • SOX2
|
GLI1 overexpression • GLI1 expression • SOX2 overexpression
3years
Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)-Related Transcription Factors and CSC-Driven Thyroid Tumor Growth. (PubMed, Cancers (Basel))
Here we report that inhibition of the Shh pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines...Our study provides evidence that activation of the Shh pathway leads to increased BMI1 and SOX2 expression in thyroid cancer and promotes thyroid CSC-driven tumor initiation. Targeting the Shh pathway may have therapeutic value for treating thyroid cancer and preventing recurrence.
Journal
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GLI1 (GLI Family Zinc Finger 1) • SOX2 • BMI1 (BMI1 proto-oncogene, polycomb ring finger) • YBX1 (Y-Box Binding Protein 1)
|
GLI1 overexpression • GLI1 expression
|
cyclopamine
over3years
Clinical value and potential association of Rab1A and FoxM1 aberrant expression in colorectal cancer. (PubMed, Sci Rep)
Besides, both high expression of Rab1A and FoxM1 led to a worse prognosis than anyone low group, and both low expression of Rab1A and FoxM1 had a better prognosis than the anyone low group. Therefore, Rab1A and FoxM1 play crucial roles and could be used as clinical biomarkers in CRC.
Clinical • Journal
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GLI1 (GLI Family Zinc Finger 1)
|
GLI1 overexpression • GLI1 expression
over3years
Galectin-1 promotes vasculogenic mimicry in gastric adenocarcinoma via the Hedgehog/GLI signaling pathway. (PubMed, Aging (Albany NY))
GAL-1 promotes VM in GC through the Hh/GLI pathway, which has potential as a novel therapeutic target for treatment of VM in GC.
Journal
|
CD34 (CD34 molecule) • GLI1 (GLI Family Zinc Finger 1) • MMP2 (Matrix metallopeptidase 2)
|
GLI1 overexpression • GLI1 expression
over3years
The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter looping GLI1-STAT3 transcriptional complex. (PubMed, J Biol Chem)
Finally, chromatin-capture PCR confirmed long-range co-regulation of SOCS2 and FLT3 through changes in promoter conformation. These findings define a mechanism whereby SULF2 drives HCC by stimulating formation of a GLI1-STAT3 transcriptional complex.
Journal
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FLT3 (Fms-related tyrosine kinase 3) • STAT3 (Signal Transducer And Activator Of Transcription 3) • GLI1 (GLI Family Zinc Finger 1) • FLT4 (Fms-related tyrosine kinase 4) • PIM1 (Pim-1 Proto-Oncogene) • SOCS2 (Suppressor Of Cytokine Signaling 2)
|
GLI1 overexpression • GLI1 expression
over3years
MGMT expression affects the gemcitabine resistance of pancreatic cancer cells. (PubMed, Life Sci)
In conclusion, MGMT inhibition could suppress the proliferation, invasion, migration and autophagy and promote the apoptosis of PanC-1/GEM cells in vitro and in vivo. PVT1 silencing may affect the PanC-1/GEM cells through changing the MGMT expression by inhibiting the SHH/GLI signaling pathway.
Journal
|
BCL2 (B-cell CLL/lymphoma 2) • CASP3 (Caspase 3) • MIR409 (MicroRNA 409)
|
GLI1 overexpression • BAX expression • miR-409 expression
|
gemcitabine
over3years
Sodium Butyrate Combined with Docetaxel for the Treatment of Lung Adenocarcinoma A549 Cells by Targeting Gli1. (PubMed, Onco Targets Ther)
This study demonstrates that the combined therapy of sodium butyrate and docetaxel additively inhibits proliferation and promotes apoptosis of A549 lung adenocarcinoma cells via suppressing Gli1 expression in vitro and in vivo. Targeting Gli1 by the combined therapy may provide new insights into the therapeutic management of patients with lung adenocarcinoma.
Journal
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BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • BIRC5 (Baculoviral IAP repeat containing 5) • GLI1 (GLI Family Zinc Finger 1) • CASP3 (Caspase 3) • CDK2 (Cyclin-dependent kinase 2) • CDK1 (Cyclin-dependent kinase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
|
CCND1 expression • BIRC5 expression • GLI1 overexpression • BAX expression • GLI1 expression • CDK2 expression
|
docetaxel
over3years
Lichen Secondary Metabolite Physciosporin Decreases the Stemness Potential of Colorectal Cancer Cells. (PubMed, Biomolecules)
Moreover, the drug significantly suppressed spheroid formation in CSC221 cells overexpressing Gli1/2 or EN1 (an S2-cleaved but membrane-tethered form of human Notch1) but did not suppress spheroid formation in cells overexpressing both Gli1/2 and ∆EN1, suggesting that physciosporin suppresses colon cancer cell stemness through the Sonic hedgehog and Notch signaling pathways. Together, these results demonstrate for the first time that physciosporin is a potent inhibitor of colorectal cancer cell stemness.
Journal
|
NOTCH1 (Notch 1) • GLI1 (GLI Family Zinc Finger 1) • HES1
|
GLI1 overexpression • GLI1 expression
over3years
Transcriptomic and Proteomic Analysis of Steatohepatitic Hepatocellular Carcinoma Reveals Novel Distinct Biologic Features. (PubMed, Am J Clin Pathol)
Steatohepatitic hepatocellular carcinoma demonstrates a distinctive morphology and gene expression profile, phenotype of zone 3 hepatocytes, and activation of the hedgehog pathway and repression of carnitine palmitoyltransferase 2, which may be important in tumorigenesis.
Journal
|
GLI1 (GLI Family Zinc Finger 1)
|
GLI1 overexpression
over3years
GLI1 activation is a key mechanism of erlotinib resistance in human non-small cell lung cancer. (PubMed, Oncol Lett)
A retrospective study of patients with NSCLC treated with erlotinib revealed that those with a high IHC score for GLI1 protein expression had a poorer prognosis. These results indicated that GLI1 is a key regulator for TKI sensitivity, and patients with lung cancer may benefit from the combined treatment of TKI and GLI1 inhibitor.
Journal
|
EGFR (Epidermal growth factor receptor) • GLI1 (GLI Family Zinc Finger 1)
|
EGFR mutation • GLI1 overexpression • GLI1 expression
|
erlotinib
almost4years
Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas. (PubMed, Clin Orthop Relat Res)
Our findings identify molecular mechanisms that possibly explain the high sensitivity of soft-tissue sarcomas to pazopanib and may lead to the development of predictive biomarkers and novel therapies in patients with this and other types of soft-tissue sarcomas.
Clinical • Journal
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KIT (KIT proto-oncogene, receptor tyrosine kinase) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • CDK4 (Cyclin-dependent kinase 4) • FLT1 (Fms-related tyrosine kinase 1) • GLI1 (GLI Family Zinc Finger 1)
|
GLI1 overexpression • GLI1 expression
|
Votrient (pazopanib)