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    GENE:

    GJA4 (Gap Junction Protein Alpha 4)

    i
    Other names: GJA4, Gap Junction Protein Alpha 4, CX37, Gap Junction Protein, Alpha 4, 37kDa, Gap Junction Alpha-4 Protein, Connexin-37, Gap Junction Protein, Alpha 4, 37kDa (Connexin 37), Gap Junction Protein, Alpha 4, 37kD (Connexin 37), Connexin 37, Cx37
    Associations

    News

    Trials
    6d
    Identifying Genetic Predisposition and Clinical Risk Factors for Breast Cancer-Related Lymphedema: Toward Personalized Prevention. (PubMed, Lymphat Res Biol)
    The GJA4 rs705193 mutations and elevated BMI independently increase the risk of BCRL in patients undergoing ALND. These findings enable the development of targeted preventive strategies for individuals at high risk.
    Journal
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    GJA4 (Gap Junction Protein Alpha 4)
    6ms
    Silk-Ovarioids: establishment and characterization of a human ovarian primary cell 3D-model system. (PubMed, Hum Reprod Open)
    The Silk-Ovarioids exhibited low intra-batch variability and long-term culture stability, underscoring their potential as a robust step toward developing a bioengineered, patient-specific artificial ovary. In addition, Silk-Ovarioids could be utilized as the first ovarian angiogenesis in vitro model, function as biological scaffold for in vitro folliculogenesis, and be used for toxicological and pharmacological studies targeting the ovaries.
    Journal
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    PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • MMP2 (Matrix metallopeptidase 2) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • CASP3 (Caspase 3) • CSF2 (Colony stimulating factor 2) • AMHR2 (Anti-Mullerian Hormone Receptor Type 2) • COL1A1 (Collagen Type I Alpha 1 Chain) • CLDN5 (Claudin 5) • GJA4 (Gap Junction Protein Alpha 4) • BMP2 (Bone Morphogenetic Protein 2)
    7ms
    Orbital angioleiomyoma with GJA4 mutation mimicking cavernous venous malformation: a case report and comprehensive review. (PubMed, Orbit)
    Angioleiomyomas may be underrecognized in orbital pathology and could represent a subset of lesions previously classified as OCVM or intracranial meningiomas. A comprehensive, multimodal diagnostic approach is essential for appropriate classification and management of these tumors.
    Journal
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    GJA4 (Gap Junction Protein Alpha 4)
    8ms
    Integrated single-cell sequencing for the development of a GJA4-based precision immuno-prognostic model in melanoma. (PubMed, Transl Oncol)
    GJA4 is highly expressed in melanoma patients, and its differential expression in tumor-associated endothelial cells influences melanoma proliferation and migration. GJA4-based risk models hold potential as predictive and therapeutic targets for personalized melanoma treatment.
    Journal
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    GJA4 (Gap Junction Protein Alpha 4)
    9ms
    A liquid biopsy approach detects HCC and identifies GJA4 as a potential biomarker for HBV-HCC via plasma cfDNA methylome profiling. (PubMed, Clin Epigenetics)
    This study provides biomarkers for detecting, staging and early detection of HCC using plasma cfDNA methylome profiling. Additionally, the dynamic alteration of GJA4 promoter methylation may serve as a molecular clue for studying HBV-related HCC carcinogenesis and prognosis.
    Journal • Liquid biopsy
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    AFP (Alpha-fetoprotein) • GJA4 (Gap Junction Protein Alpha 4)
    11ms
    Regulation of serum reproductive hormones, gap junction proteins, and cytokine profiles in laying hens fed varying levels of expanded black soldier fly meal. (PubMed, Poult Sci)
    Our findings also strongly indicate estrogen plays a role in modulating the expression of connexins. These findings suggest that lower EP-BSF in layer diet may serve as an alternative protein source for poultry feed.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • GJA1 (Gap Junction Protein Alpha 1) • GJA4 (Gap Junction Protein Alpha 4)
    1year
    Construction of the bromodomain-containing protein-associated prognostic model in triple-negative breast cancer. (PubMed, Cancer Cell Int)
    A novel prognostic model for TNBC associated with BRDRGs was developed and validated, providing fresh insights into the relationship between BRD and TNBC.
    Journal
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    TP53 (Tumor protein P53) • CTSD (Cathepsin D) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • EDNRB (Endothelin Receptor Type B) • GJA4 (Gap Junction Protein Alpha 4) • KRT6A (Keratin 6A)
    over1year
    Intracranial angioleiomyoma mimicking meningioma: an uncommon tumor with favorable outcome and frequent GJA4 mutation. (PubMed, Neurosurg Rev)
    IALM had favorable outcome. Notably, IALMs frequently exhibited a GJA4 mutation, which was linked to the cavernous sinus and orbital locations, as well as PR expression.
    Journal
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    PGR (Progesterone receptor) • GJA4 (Gap Junction Protein Alpha 4)
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    PGR expression
    over1year
    VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17. (PubMed, BMC Biol)
    Together, our data highlight an essential role for VEGF-dependent MEK1/2 signalling in promoting vasculature and indicate that FGF signalling through MEK1/2 regulates Sertoli cell organisation in the developing mouse testis.
    Journal
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    MAP2K1 (Mitogen-activated protein kinase kinase 1) • POU5F1 (POU Class 5 Homeobox 1) • SOX17 (SRY-Box Transcription Factor 17) • SOX9 (SRY-Box Transcription Factor 9) • CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • CDH5 (Cadherin 5) • GJA4 (Gap Junction Protein Alpha 4)
    over1year
    Transcriptomic Differences by RNA Sequencing for Evaluation of New Method for Long-Time In Vitro Culture of Cryopreserved Testicular Tissue for Oncologic Patients. (PubMed, Cells)
    Encapsulation of testicular tissue in fibrin and long-time in vitro culture with constant stirring in a large volume of culture medium can reduce the impact of thawing methods on cryopreserved testicular tissue.
    Preclinical • Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • CTGF (Connective tissue growth factor) • GJA4 (Gap Junction Protein Alpha 4)
    over1year
    A novel cancer-associated fibroblast signature for kidney renal clear cell carcinoma via integrated analysis of single-cell and bulk RNA-sequencing. (PubMed, Discov Oncol)
    This study firstly developed a novel predictive model based on 6 CAFs genes for KIRC. Additionally, PGF may present a potential therapeutic target to enhance KIRC treatment.
    Journal
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    FLT1 (Fms-related tyrosine kinase 1) • GJA4 (Gap Junction Protein Alpha 4) • TPM2 (Tropomyosin 2)
    over1year
    GJA4 expressed on cancer associated fibroblasts (CAFs)-A 'promoter' of the mesenchymal phenotype. (PubMed, Transl Oncol)
    We have identified GJA4 expressed on fibroblasts is actually a promoter of the tumor mesenchymal phenotype. Our findings suggest that the interaction between GJA4+ fibroblasts and M2 macrophages may be an effective target for enhancing tumor immunotherapy.
    Journal • IO biomarker
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    GJA4 (Gap Junction Protein Alpha 4)