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    GENE:

    GJA1 (Gap Junction Protein Alpha 1)

    i
    Other names: GJA1, Gap Junction Protein Alpha 1, Gap Junction Protein Alpha 1 43kDa, Gap Junction 43 KDa Heart Protein, Gap Junction Alpha-1 Protein, Connexin-43, GJAL, Gap Junction Protein Alpha 1 43kDa (Connexin 43), Oculodentodigital Dysplasia (Syndactyly Type III) , Gap Junction Protein Alpha-Like, Connexin 43, AVSD3, EKVP3, HLHS1, PPKCA, CMDR, CX43, EKVP, ODDD, Cx43, HSS
    3d
    SnRNA-seq reveals the ameliorative effects of optimized Xueyu Jingshen formula on high altitude cerebral edema by modulating energy metabolism, inflammation and BBB integrity. (PubMed, Phytomedicine)
    This study provides and defines the first systematic snRNA-seq profiles under OXJF-treated HACE mice. The potential mechanisms of OXJF in treating HACE were related to maintaining energy metabolism, inflammation and BBB homeostasis.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • TLR4 (Toll Like Receptor 4) • GJA1 (Gap Junction Protein Alpha 1) • PDGFA (Platelet Derived Growth Factor Subunit A) • TNFRSF11A (TNF Receptor Superfamily Member 11a) • IRAK1 (Interleukin 1 Receptor Associated Kinase 1)
    2ms
    The Cx43-Mediated Autophagy Mechanism Influences Triple-Negative Breast Cancer Through the Regulation of Rab31. (PubMed, Cancers (Basel))
    The Cx43/Rab31 axis drives autophagy to facilitate TNBC progression, highlighting Cx43 as a potential therapeutic target. Our findings provide mechanistic insights for improving TNBC treatment.
    Journal
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    GJA1 (Gap Junction Protein Alpha 1) • ATG5 (Autophagy Related 5)
    2ms
    Molecular Mechanism of the IRF1/NFE2L1-DT/ALKBH5/Cx43 Axis in Radiation-Induced Injury in Vascular Endothelial Cells Through Pyroptosis. (PubMed, Kaohsiung J Med Sci)
    Overexpression of NFE2L1-DT or ALKBH5, or silencing Cx43, attenuated the protective effects of IRF1 silencing against radiation-induced damage. These findings indicate that radiation-induced IRF1 upregulation leads to endothelial injury by promoting pyroptosis through the NFE2L1-DT/ALKBH5/Cx43 axis.
    Journal
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    IL18 (Interleukin 18) • IRF1 (Interferon Regulatory Factor 1) • GJA1 (Gap Junction Protein Alpha 1) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • ALKBH5 (AlkB Homolog 5, RNA Demethylase) • H2AX (H2A.X Variant Histone) • PELP1 (Proline, Glutamate And Leucine Rich Protein 1) • CASP1 (Caspase 1)
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    LDH elevation
    3ms
    Mitochondrial connexin 43 modulates metabolic stress adaptation in glioma cell lines. (PubMed, Cell Commun Signal)
    Our results suggest that mt-CX43 serves as a multifunctional regulator of metabolic adaptation and stress response in glioma cell lines. Our results extend the role of mt-CX43 as an essential factor in cellular metabolic plasticity, providing new insights into the modulation of metabolic imbalances and mitochondrial dysfunction.
    Preclinical • Journal
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    GJA1 (Gap Junction Protein Alpha 1) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
    3ms
    The role of nitric oxide and connexin 43 in the cardioprotective effects of apigenin against doxorubicin-induced cardiotoxicity in male rats. (PubMed, Mol Biol Rep)
    Apigenin can also elevate the cardiac CX43 expression in the DOX + Api compared to the DOX group. NOS inhibition by L-NAME attenuates the protective effects of apigenin in DOX-induced cardiotoxicity COCCLUSION: Apigenin could exert its cardioprotective effects through an NO-dependent mechanism and elevation of CX43 expression.
    Preclinical • Journal
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    GJA1 (Gap Junction Protein Alpha 1) • CAT (Catalase)
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    doxorubicin hydrochloride
    4ms
    Novel Cross-Cancer Hub Genes in Doxorubicin Resistance Identified by Transcriptional Mapping. (PubMed, Biomedicines)
    This integrative analysis identifies conserved transcriptomic signatures of DOX resistance and highlights hub genes GJA1, SEH1L, TCF3, TUBA4A, and ZYX with potential as predictive biomarkers and therapeutic targets. Targeting these pathways may help overcome chemoresistance and improve treatment outcomes in cancer patients.
    Journal
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    TCF3 (Transcription Factor 3) • GJA1 (Gap Junction Protein Alpha 1)
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    doxorubicin hydrochloride
    5ms
    Role of connexin 43 in odontogenesis and odontogenic tumors. (PubMed, Histol Histopathol)
    Cx43 emerges as a promising diagnostic, prognostic, and therapeutic biomarker in different neoplasias, warranting further investigation to optimize clinical applications. The objective of this work is to review current information on the role of CX43 in normal tissue and odontogenic tumors to evaluate its possible usefulness as a future therapeutic target.
    Review • Journal
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    GJA1 (Gap Junction Protein Alpha 1)
    5ms
    RNA m5C Modifications in the Development and Prognosis of Muscle-Invasive Bladder Cancer. (PubMed, Mol Carcinog)
    This approach yielded an optimized 11-gene prognostic signature comprising GGA1, NUMBL, ECHDC2, NLRC5, EIF2D, GJA1, XPC, DAZAP2, C6orf120, WDR45, and CES1, which demonstrated superior predictive performance in TCGA MIBC patients. These findings establish m5C RNA modification patterns as promising molecular signatures for MIBC prognosis and potential therapeutic targets.
    Journal
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    PTEN (Phosphatase and tensin homolog) • SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • FADD (Fas associated via death domain) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • BMI1 (BMI1 proto-oncogene, polycomb ring finger) • NLRC5 (NLR Family CARD Domain Containing 5) • XPC (XPC Complex Subunit, DNA Damage Recognition And Repair Factor) • FOXO3 (Forkhead box O3) • GJA1 (Gap Junction Protein Alpha 1) • PAK2 (P21 (RAC1) Activated Kinase 2) • CCNG1 (Cyclin G1) • NUMBL (NUMB Like Endocytic Adaptor Protein)
    5ms
    Shared Molecular Mechanisms Between Type 2 Diabetes and Thyroid Cancer: Integrated Bioinformatics Insights for Prognostic Biomarker Discovery. (PubMed, Endocr Connect)
    T2D and TC exhibit overlapping genetic dysregulation, particularly in pathways governing metabolic reprogramming and tumor microenvironment crosstalk. Notably, PRDM1 and ZFPFM2 may serve as therapeutic targets for TC in patients with concurrent diabetes.
    Journal
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    GJA1 (Gap Junction Protein Alpha 1) • PRDM1 (PR/SET Domain 1) • TGFBI (Transforming Growth Factor Beta Induced) • RUNX2 (RUNX Family Transcription Factor 2)
    7ms
    Identification of key ferroptosis-related genes associated with the development of gastric cancer: Prognostic models, molecular mechanisms and potential treatment strategies. (PubMed, Oncol Lett)
    Finally, using the Genomics of Drug Sensitivity in Cancer and Cancer Therapeutics Response Portal databases, potential drugs [(5Z)-7-oxozeaenol, selumetinib, RDEA119, AZ628, dabrafenib and trametinib] were identified based on the aforementioned seven key carcinogenic genes, focusing on those that targeted multiple genes. In conclusion, the present study identified 14 key ferroptosis-related genes, and seven key carcinogenic genes, which represent promising novel molecular targets for the prognosis and treatment of GC.
    Journal
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    GJA1 (Gap Junction Protein Alpha 1) • AKR1C2 (Aldo-Keto Reductase Family 1 Member C2) • GABARAP (GABA Type A Receptor-Associated Protein) • MIR484 (MicroRNA 484) • NOX4 (NADPH Oxidase 4) • GABARAPL2 (GABA Type A Receptor Associated Protein Like 2) • MIR675 (MicroRNA 675) • NOX5 (NADPH Oxidase 5)
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    Mekinist (trametinib) • Tafinlar (dabrafenib) • Koselugo (selumetinib) • refametinib (BAY86-9766) • AZ 628
    8ms
    Fluorescence Guided Raman Spectroscopy enables the training of robust support vector machines for the detection of tumour marker proteins. (PubMed, Sci Rep)
    Thus, FGRS enables the spectral isolation of tumour marker proteins and the development of robust classifiers across cell lines. By focusing on key Raman shifts, this method holds the potential to improve diagnostic accuracy and sensitivity, offering a customizable tool for tumour detection.
    Journal
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    GJA1 (Gap Junction Protein Alpha 1)
    8ms
    TRIB3 regulates Cx43 expression in human granulosa cells via the Wnt/β-catenin signaling pathway: an in vitro study. (PubMed, J Ovarian Res)
    TRIB3 overexpression can enhance Cx43 expression in human GCs by inhibiting the Wnt/β-catenin pathway, thereby reducing oocyte maturation rate. These findings could be used to improve the quality of female oocytes and enhance infertility therapy in the clinic.
    Preclinical • Journal
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    GJA1 (Gap Junction Protein Alpha 1) • TRIB3 (Tribbles Pseudokinase 3)