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BIOMARKER:

GJA1 expression

i
Other names: GJA1, Gap Junction Protein Alpha 1, Gap Junction Protein Alpha 1 43kDa, Gap Junction 43 KDa Heart Protein, Gap Junction Alpha-1 Protein, Connexin-43, GJAL, Gap Junction Protein Alpha 1 43kDa (Connexin 43), Oculodentodigital Dysplasia (Syndactyly Type III) , Gap Junction Protein Alpha-Like, Connexin 43, AVSD3, EKVP3, HLHS1, PPKCA, CMDR, CX43, EKVP, ODDD, Cx43, HSS
Entrez ID:
Related biomarkers:
4d
Lack of canonical activities of connexins in highly aggressive human prostate cancer cells. (PubMed, Biol Res)
Immunofluorescence analyses confirmed that the majority of Cx26, Cx32, and Cx43 expression was localized in the cytoplasm of both LNCaP and PC3 cell lines. This data indicated that GJ and HC activities were moderately detected only in the less aggressive PCa cells, which suggest that Cxs expression in highly aggressive PCa cells could be associated to channel-independent roles.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
20d
CX43-mediated mitochondrial transfer maintains stemness of KG-1a leukemia stem cells through metabolic remodeling. (PubMed, Stem Cell Res Ther)
CX43-mediated mitochondrial transfer from BMSCs to KG-1a enhances LSCs adhesion, proliferation, clonogenicity, and metabolic reprogramming. CX43 emerges as a potential therapeutic target for AML by sustaining LSCs stemness through metabolic remodeling.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
1m
Inhibition of miR-20a-5p Suppresses Epithelial-Mesenchymal Transition of Colorectal Cancer Cells Through GJA1. (PubMed, Mol Biotechnol)
miR-20a-5p inhibitor + sh-GJA1 promoted the invasion, migration, and proliferation of colon cancer cells and EMT process. Overall, miR-20a-5p could target GJA1 to down-regulate the GJA1 expression, thereby regulating the EMT response, and ultimately promoting the progression of colorectal cancer.
Journal
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CDH1 (Cadherin 1) • VIM (Vimentin) • CDH2 (Cadherin 2) • GJA1 (Gap Junction Protein Alpha 1) • MIR20A (MicroRNA 20a)
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CDH1 expression • VIM expression • GJA1 expression
1m
Glioma-Astrocyte connexin43 confers temozolomide resistance through activation of the E2F1/ERCC1 axis. (PubMed, Neuro Oncol)
Our study reveals a novel regulatory mechanism in which the Cx43/miR-205-5p/E2F1/ERCC1 axis contributes to TMZ resistance in glioma. These findings further highlight the potential of targeting Cx43 as a therapeutic strategy in glioma.
Journal
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ERCC1 (Excision repair cross-complementation group 1) • GJA1 (Gap Junction Protein Alpha 1) • E2F1 (E2F transcription factor 1) • GFAP (Glial Fibrillary Acidic Protein) • MIR205 (MicroRNA 205)
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GJA1 expression
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temozolomide
2ms
Biomarker Profiles and Clinicopathological Features in Head and Neck Squamous Cell Carcinoma Patients. (PubMed, Medicina (Kaunas))
Women may develop more aggressive tumors, and extralaryngeal tumors often present with more challenging prognoses. Low Cx43 expression may be more likely to coincide with higher Ki67 and COX-2 levels, possibly indicating a link with more aggressive tumor behavior.
Journal
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EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • STAT3 (Signal Transducer And Activator Of Transcription 3) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • GJA1 (Gap Junction Protein Alpha 1)
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TP53 mutation • EGFR expression • TP53 expression • GJA1 expression
2ms
Inhibiting lncRNA NEAT1 Increases Glioblastoma Response to TMZ by Reducing Connexin 43 Expression. (PubMed, Cancer Rep (Hoboken))
Overall, these results indicated that the NEAT1/miR-454-3p/Connexin 43 pathway influences GBM cell response to TMZ and could offer a potential new strategy for treating GBM.
Journal
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NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • GJA1 (Gap Junction Protein Alpha 1) • MIR454 (MicroRNA 454)
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GJA1 expression
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temozolomide
8ms
Effects of Gap 26, a Connexin 43 Inhibitor, on Cirrhotic Cardiomyopathy in Rats. (PubMed, Cureus)
The Cx43 expression was downregulated in the CCl4/saline and upregulated with the Gap 26 treatment. Conclusion Gap 26 not only alleviated the chronotropic hyporesponsiveness and the severity of liver damage and upregulated the atrial Cx43 expression, but it also had an antioxidant effect on the heart.
Preclinical • Journal
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TNFA (Tumor Necrosis Factor-Alpha) • GJA1 (Gap Junction Protein Alpha 1)
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CCL4 elevation • GJA1 expression
8ms
Effect of connexin 43 in LPS/IL-4-induced macrophage M1/M2 polarization: An observational study. (PubMed, Medicine (Baltimore))
Thus, Cx43 expression in M2-type polarization experiences a reduction at first and then an increase from 24 hours to 48 hours. The direction of macrophage polarization can be controlled by regulating the expression of Cx43, thus providing a theoretical basis for treating atherosclerosis, tumors, and other diseases associated with macrophage polarization.
Observational data • Journal
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GJA1 (Gap Junction Protein Alpha 1) • IL4 (Interleukin 4)
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GJA1 expression • GJA1 overexpression
8ms
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway. (PubMed, Radiat Res)
Administration of the PI3K/AKT pathway inhibitor LY294002 inhibited the radioprotective effects in Cx43-overexpressing intestinal epithelial cells. Our study demonstrated that Cx43 expression is decreased by ionizing radiation, which facilitates the radioprotection of intestinal epithelial cells.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression • GJA1 overexpression
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LY294002
10ms
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway. (PubMed, Radiat Res)
Administration of the PI3K/AKT pathway inhibitor LY294002 inhibited the radioprotective effects in Cx43-overexpressing intestinal epithelial cells. Our study demonstrated that Cx43 expression is decreased by ionizing radiation, which facilitates the radioprotection of intestinal epithelial cells.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression • GJA1 overexpression
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LY294002
11ms
Loss of Function of the Retinoblastoma Gene Affects Gap Junctional Intercellular Communication and Cell Fate in Osteoblasts. (PubMed, Biology (Basel))
Our observations suggest that increased PPAR-ɣ that happens with Rb1 loss only affects osteoblast-adipocyte-specific gene expression but does not completely reverse Cx43 gene expression or GJIC. Therefore, these effects may represent independent events triggered by Rb1loss and/or the differentiation process.
Journal
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RB1 (RB Transcriptional Corepressor 1) • CDH2 (Cadherin 2) • GJA1 (Gap Junction Protein Alpha 1) • CDH11 (Cadherin 11) • RUNX2 (RUNX Family Transcription Factor 2)
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RB1 expression • GJA1 expression
1year
METTL3 promotes choriocarcinoma progression by activating the miR-935/GJA1 pathway in an m6A-dependent manner. (PubMed, Am J Reprod Immunol)
METTL3 promoted miR-935 maturation by inducing m6A methylation of pri-miR-935, and its overexpression contributed to CCA cell tumor properties through the regulation of miR-935. METTL3 promoted choriocarcinoma progression by m6A-dependently activating the miR-935/GJA1 pathway.
Journal
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GJA1 (Gap Junction Protein Alpha 1) • METTL3 (Methyltransferase Like 3)
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GJA1 expression
1year
AS602801 treatment suppresses breast cancer metastasis to the brain by interfering with gap-junction communication by regulating Cx43 expression. (PubMed, Drug Dev Res)
AS602801 downregulates the expressions of JNK and Cx43 to suppress the gap-junction activity. AS602801 also inhibits the communication between breast cancer cells and astrocytes, thus contributing to the treatment of brain metastasis in breast cancer.
Journal
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GJA1 (Gap Junction Protein Alpha 1) • MAPK8 (Mitogen-activated protein kinase 8)
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GJA1 expression
1year
Fluoxetine enhances the antitumor effect of olfactory ensheathing cell-thymidine kinase/ganciclovir gene therapy in human glioblastoma multiforme cells through upregulation of Connexin43 levels. (PubMed, Drug Dev Res)
Moreover, flow cytometry data indicated that fluoxetine increased the percentage of apoptotic cells in the coculture system. This study suggests that fluoxetine, by upregulating Cx43 levels, could strengthen the Antitumor effect of OEC-TK/GCV gene therapy on GBM cells.
Journal • IO biomarker • Gene therapy
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
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fluoxetine
over1year
Correlation between connexin 43 expression in circulating tumor cells and biological characteristics of breast cancer. (PubMed, Heliyon)
Univariate Cox regression analysis revealed that Cx43 expression, Her2 expression, and tumor size were significantly correlated with DFS (P = 0.03, 0.0023, and 0.01, respectively). Cx43 expression in the CTCs of patients with breast cancer is a cancer-promoting factor.
Journal • Circulating tumor cells • Tumor cell
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HER-2 (Human epidermal growth factor receptor 2) • GJA1 (Gap Junction Protein Alpha 1)
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HER-2 overexpression • GJA1 expression
over1year
CX43 down-regulation promotes cell aggressiveness and 5-fluorouracil-resistance by attenuating cell stiffness in colorectal carcinoma. (PubMed, Cancer Biol Ther)
Moreover, we also highlight that the downregulation of CX43 in CRC increases the stemness of cells via reducing the cell stiffness, thus promoting the drug resistance. Our results further suggest that both effects, that is changes in the mechanical stiffness of the cell and GJIC mediated by CX43 deregulated, are closely related to drug resistance in CRC, which indicating CX43 as a target against cancer growth and chemoresistance in CRC.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression • GJA1 overexpression
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5-fluorouracil
over1year
Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors. (PubMed, Transl Oncol)
Cx43 is strongly associated with RTK expression and ccRCC progression, while tangeretin can inhibit RCC cell malignancy by inhibiting Cx43 expression and enhance the sensitivity of RCC cells to TKIs.
Journal
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EGFR (Epidermal growth factor receptor) • KDR (Kinase insert domain receptor) • FLT1 (Fms-related tyrosine kinase 1) • BIRC5 (Baculoviral IAP repeat containing 5) • FLT4 (Fms-related tyrosine kinase 4) • GJA1 (Gap Junction Protein Alpha 1) • MMP9 (Matrix metallopeptidase 9)
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KDR expression • BIRC5 expression • FLT1 expression • GJA1 expression
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sorafenib • sunitinib
over1year
Connexin 43 expression in tooth germ and benign odontogenic tumors. (PubMed, Oral Surg Oral Med Oral Pathol Oral Radiol)
The results obtained in this study showed that Cx43 is a protein with important expression in the mesenchymal layer of the embryonic and odontogenic tissues studied. It could be speculated that Cx43 participates in mineralization events based on the relationship of the expression of this protein between the epithelial and mesenchymal layers of odontogenic tissues.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
over1year
The relationship between connexin-43 expression and Ki67 in non-glial central nervous system tumors. (PubMed, Int J Biol Markers)
The expression of Cx43 as a marker of cell-to-cell networking exposed a significant correlation with the Ki67-defined proliferation index in case of primary central nervous system neuroectodermal neoplasms. However, it does not seem to play a comparable role in metastases with extracerebral origin.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
over1year
Connexin 43-modified bone marrow stromal cells reverse the imatinib resistance of K562 cells via Ca 2+ -dependent gap junction intercellular communication. (PubMed, Chin Med J (Engl))
Cx43 deficiency exists in CML patients, promoting the generation of MRD and inducing drug resistance. Enhancing Cx43 expression and GJIC function in the HM may be a novel strategy to reverse drug resistance and promote IM efficacy.
Journal • Stroma
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HIF1A (Hypoxia inducible factor 1, alpha subunit) • GJA1 (Gap Junction Protein Alpha 1)
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HIF1A expression • GJA1 expression • GJA1 overexpression
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imatinib
almost2years
αCT1 Peptide Sensitizes Glioma Cells to Temozolomide in a Glioblastoma Organoid Platform. (PubMed, Biotechnol Bioeng)
Confocal imaging was used to visualize changes in Cx43 expression in response to combinatorial treatment. These results indicate that Cx43 inhibition should be pursued further as an improved treatment for GBM.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
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temozolomide
almost2years
Analysis of connexin 43, connexin 45 and N-cadherin in the human sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in comparison with human testicular biopsies. (PubMed, BMC Cancer)
The junctional proteins Cx43, Cx45 and N-cadherin are expressed in FS1 and TCam-2 cells at mRNA and/or protein level in different amounts and localizations, and cells of both lines are functionally coupled among each other. Concerning the expression of these junctional proteins, FS1 and TCam-2 cells are largely representative for Sertoli and seminoma cells, respectively. Thus, these results provide the basis for further coculture experiments evaluating the role of junctional proteins in context with seminoma progression.
Preclinical • Journal • Biopsy
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CDH2 (Cadherin 2) • GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
almost2years
Knockdown of the long non‑coding RNA MALAT1 ameliorates TNF‑α‑mediated endothelial cell pyroptosis via the miR‑30c‑5p/Cx43 axis. (PubMed, Mol Med Rep)
Finally, co‑transfection with siMALAT1 and miR‑30c‑5p inhibitor could attenuate the protective effect of MALAT1 knockdown against TNF‑α‑mediated RAOEC pyroptosis by upregulation of Cx43 expression. In conclusion, MALAT1 might serve an important role in TNF‑α‑mediated RAOEC pyroptosis by regulating the miR‑30c‑5p/Cx43 axis, which would provide a potential novel diagnostic and therapeutic target for AS.
Journal
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TNFA (Tumor Necrosis Factor-Alpha) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • GJA1 (Gap Junction Protein Alpha 1) • MIR30C
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GJA1 expression
almost2years
Ubiquitin-Related Modifier 1 (URM-1) Modulates Cx43 in Breast Cancer Cell Lines. (PubMed, Int J Mol Sci)
Inversely, the upregulation of URM-1 increased Cx43 expression and reversed EMT-induced processes, underpinning a role for this PTM in the observed phenotypes. This study proposes that the URMylation of Cx43 in breast cancer cells regulates its tumor suppression properties and contributes to breast cancer cell malignancy.
Preclinical • Journal
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
almost2years
Intercellular delivery of therapeutic oligonucleotides. (PubMed, J Drug Deliv Sci Technol)
Our results show that both gap junction and vesicular/exosomal intercellular delivery pathways from hMSCs to target cancer cells deliver oligonucleotides and function to either induce cell death or significantly reduce their proliferation. Thus, hMSC-based cellular delivery is an effective method of delivering synthetic oligonucleotides that can significantly reduce tumor cell growth and should be further investigated as a possible approach to cancer therapy.
Journal
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GJA1 (Gap Junction Protein Alpha 1) • MIR16 (MicroRNA 16)
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GJA1 expression
almost2years
Connexin 43 trafficking and regulation of gap junctional intercellular communication alters ovarian cancer cell migration and tumorigenesis. (PubMed, Biomed Pharmacother)
In summary, the 4PBA-mediated restoration of GJIC suppressed migration (in vitro) and tumorigenesis (in vivo) of ovarian cancer cells. The present study suggests that Cx43 assembled GJIC and its supportive signaling pathways are a prospective target for restricting ovarian cancer progression.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
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VEGFA overexpression • VEGFA expression • GJA1 expression
2years
Down-regulation of CX43 expression by miR-1 inhibits the proliferation and invasion of glioma cells. (PubMed, Transl Cancer Res)
Connexin (CX) 43 makes glioblastoma resistant to temozolomide, the first-line chemotherapy drug...The dual-luciferase assay showed that miR-1-3p had a targeted relationship with the CX43 gene. Down-regulation of CX43 expression by miR-1 inhibited the infiltration and growth of glioma cells and further promoted the apoptosis of glioma cells by regulating CX43 expression.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
|
GJA1 expression
|
temozolomide
2years
Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal cancer. (PubMed, World J Gastroenterol)
These results suggest that TET-2 expression levels, as well as Cx43 expression levels, are modulated in models of intestinal inflammation. We hypothesize that TET-2 may demethylate genes involved in inflammation and tumorigenesis, such as Cx43, potentially contributing to intestinal inflammation and associated carcinogenesis.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
2years
Arteannuin B Enhances the Effectiveness of Cisplatin in Non-Small Cell Lung Cancer by Regulating Connexin 43 and MAPK Pathway. (PubMed, Am J Chin Med)
Art B increased intracellular Fe[Formula: see text] level, promoted calcium influx, and activated gap junction and MAPK pathways, which might contribute to Art B-mediated effects. Art B may serve as a new drug candidate to enhance the antitumor effect of DDP on NSCLC.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
|
GJA1 expression
|
cisplatin
2years
Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK1 signaling axis (SNO 2022)
Current work is focused on interrogating the link among Cx43, WNK1 phosphorylation, and downstream signaling events and the therapeutic window of WNK1 inhibition. This work identifies a potential new signaling axis downstream of Cx43 in glioblastoma CSCs and further strengthens the hypothesis that connexins may act as both tumor suppressors and tumor drivers depending on context.
GJA1 (Gap Junction Protein Alpha 1) • WNK1 (WNK Lysine Deficient Protein Kinase 1)
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GJA1 expression
over2years
Connexin 43 Contributes to the Sensitization of Colorectal Cancer Cells to Photodynamic Therapy through Akt Inhibition. (PubMed, Photodiagnosis Photodyn Ther)
Connexin 43 should be considered an important factor in increasing the phototoxicity of photodynamic therapy in colorectal cancer through Akt inhibition.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
|
GJA1 expression
|
LY294002
over2years
β2-Adrenergic receptor agonist enhances the bystander effect of HSV-TK/GCV gene therapy in glioblastoma multiforme via upregulation of connexin 43 expression. (PubMed, Mol Ther Oncolytics)
Gene therapy using the herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) is a new strategy for GBM treatment...Also, the flow cytometry results revealed that Cln increased apoptosis in the co-culture of GBM cells and OEC-TK cells. This study showed that Cln via upregulation of Cx43 expression could enhance the bystander effect of HSVTK-GCV gene therapy in human GBM cells.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • GJA1 (Gap Junction Protein Alpha 1)
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BCL2 expression • BAX expression • GJA1 expression
over2years
Tat-Cx43266-283 reduces the viability of mouse lung cancer stem cells (EACR 2022)
Conclusion Tat-Cx43 266-283 is proving to have a significant antiproliferative effect in the non-adherent subpopulation of 3LL lung cancer cell line, as it does in glioma stem cells. These results aim us to explore further this effect, including lung cancer brain metastasis models to address Tat-Cx43 266-283 impact within the brain microenvironment, a favourable niche for the development of lung cancer metastasis
Preclinical
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GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
over2years
The Expression of Connexin 37, 40, 43, 45 and Pannexin 1 in the Early Human Retina and Choroid Development and Tumorigenesis. (PubMed, Int J Mol Sci)
Whereas Cx45 is involved in early stages of eye development, Pnx1might influence cell metabolism. Additionally, Cx43 might be a potential biomarker of tumor prognosis.
Journal
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GJA1 (Gap Junction Protein Alpha 1)
|
GJA1 expression
over2years
Dioscin potentiates the antitumor effect of suicide gene therapy in melanoma by gap junction intercellular communication-mediated antigen cross-presentation. (PubMed, Biomed Pharmacother)
This study aimed to explore the effect of Dio on the immune-related modulation and synergistic therapeutic effects of the herpes simplex virus thymidine kinase/ganciclovir (HSV-Tk/GCV) suicide gene therapy system in murine melanoma, thereby providing a research basis to improve the potential immunomodulatory mechanism underlying combination therapy...The increased number and activation ratio of CD8 T lymphocytes and the levels of Gzms-B, IFN-γ, and TNF-α in mice reconfirmed the potential modulatory effects of Dio on the immune system. Taken together, Dio targets Cx43 to enhance GJIC function, improve the antigens cross-presentation of DCs, and activate the antitumor immune effect of CD8 T lymphocytes, thereby providing insights into the potential immunomodulatory mechanism underlying combination therapy.
Journal
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • GJA1 (Gap Junction Protein Alpha 1)
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GJA1 expression
over2years
Hypoxic pancreatic cancer derived exosomal miR-30b-5p promotes tumor angiogenesis by inhibiting GJA1 expression. (PubMed, Int J Biol Sci)
In addition, there were significant correlations for the levels of total miR-30b-5p or exosomal miR-30b-5p between peripheral blood plasma and portal vein plasma. Hypoxic PDAC cells derived exosomal miR-30b-5p promoted angiogenesis by inhibiting GJA1, and miR-30b-5p was a potential diagnostic marker for PDAC.
Journal
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GJA1 (Gap Junction Protein Alpha 1) • MIR30B (MicroRNA 30b)
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GJA1 expression
over2years
lncRNA LEF1-AS1 Acts as a Novel Biomarker and Promotes Hypopharyngeal Squamous Cell Carcinoma Progression and Metastasis by Targeting the miR-221-5p/GJA1 Axis. (PubMed, Dis Markers)
Most importantly, we illustrated that LEF1-AS1 played as a competitive endogenous RNA (ceRNA) via sponging miR-221-5p and thereby positively regulated gap junction protein alpha 1 (GJA1) expression, thus aggravated tumor progression and EMT. In conclusion, for the first time, we demonstrated lncRNA LEF1-AS1 as a novel biomarker for HNSCC and suggested LEF1-AS1/miR-221-5p/GJA1 axis as promising diagnostic and therapeutic target for HSCC treatment.
Journal
|
GJA1 (Gap Junction Protein Alpha 1) • MIR221 (MicroRNA 221)
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GJA1 expression
almost3years
Expression of connexin-43 in surgical resections of primary tumor and lymph node metastases of squamous cell carcinoma and adenocarcinoma of the lung: a retrospective study. (PubMed, PeerJ)
We highlighted that SqCC expressed Cx43 more than did AC, both in primary tumor and lymphatic metastases. Further research is needed to establish whether Cx43 could be used as a prognostic biomarker in lung carcinoma.
Retrospective data • Journal
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GJA1 (Gap Junction Protein Alpha 1)
|
GJA1 expression