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    GENE:

    GIMAP6 (GTPase, IMAP Family Member 6)

    i
    Other names: GIMAP6, GTPase, IMAP Family Member 6, IAN6, Immune-Associated Nucleotide-Binding Protein 6, GTPase IMAP Family Member 6, FLJ22690, IAN-2, IAN-6, IAN2, Immunity-Associated Nucleotide 2 Protein, Immunity-Associated Nucleotide 6 Protein, Immune Associated Nucleotide 2, Immune Associated Nucleotide 6, HIAN2, HIAN6
    over1year
    Identification of potential biomarkers for lung adenocarcinoma: a study based on bioinformatics analysis combined with validation experiments. (PubMed, Front Oncol)
    Finally, Irinotecan and Hesperetin were predicted through DGIDB database. In this study, TGFBR2 was identified as a biomarker of LUAD, which provided a new idea for the treatment strategy of LUAD and may aid in the development of personalized immunotherapy strategies.
    Journal • IO biomarker
    |
    CAV1 (Caveolin 1) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • CD31 (Platelet and endothelial cell adhesion molecule 1) • GIMAP6 (GTPase, IMAP Family Member 6) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)
    |
    irinotecan
    over1year
    Identification and validation of GIMAP family genes as immune-related prognostic biomarkers in lung adenocarcinoma. (PubMed, Heliyon)
    In this study, we identified that GIMAP family genes were significantly associated with immune cell infiltration and immune checkpoint molecules. They potentially play a critical role in anti-tumor immunity and serve as immunotherapy biomarkers.
    Journal • IO biomarker
    |
    GIMAP6 (GTPase, IMAP Family Member 6)
    over2years
    Investigation and verification of GIMAP6 as a robust biomarker for prognosis and tumor immunity in lung adenocarcinoma. (PubMed, J Cancer Res Clin Oncol)
    These findings confirmed that GIMAP6 was an effective prognostic molecule that was involved in the regulation of the immune microenvironment of LUAD, and may become a predictor for the efficacy of immunotherapy.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • GIMAP6 (GTPase, IMAP Family Member 6)
    |
    GIMAP6 overexpression