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    GENE:

    GHR (Growth Hormone Receptor 2)

    i
    Other names: GHR, Growth Hormone Receptor 2, GHBP, Growth Hormone Binding Protein, Somatotropin Receptor, GH Receptor, Truncated Growth Hormone Receptor, Mutant Growth Hormone Receptor, Serum Binding Protein, GHIP
    almost2years
    Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer. (PubMed, Clin Res Cardiol)
    In advanced cancer, reduced LVmass is associated with increased plasma GH and reduced IGF-I/GH ratio, suggesting increasing GH resistance, especially for patients with wasting syndrome with unintentional weight loss. Higher baseline IGF-I was associated with a decrease in relative LVmass during follow-up.
    Journal • Metastases
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    IGF1 (Insulin-like growth factor 1) • GHR (Growth Hormone Receptor 2)
    3years
    Clinical significance and prognostic value of receptor conversion after neoadjuvant chemotherapy in breast cancer patients. (PubMed, Front Surg)
    Patients with HR conversion after NAC who received endocrine therapy had better DFS (P = 0.674) and OS (P = 0.363) than those who did not receive endocrine therapy, even if the HR changed from positive to negative. In conclusion, pathological testing should be performed before and after NAC, and even patients with HR conversion after NAC might benefit from endocrine therapy.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • GHR (Growth Hormone Receptor 2)
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    HER-2 expression
    over3years
    Placebo-Controlled and Open-Label Extension Study of a Novel Hepatic-Targeted Antisense Cimdelirsen (IONIS-GHR-LRx) Under Investigation in Acromegaly Patients) (ENDO 2022)
    Once monthly SC cimdelirsen injections demonstrated long-term safety, were well-tolerated, and resulted in significant reductions in GHBP and IGF-1 AUC without increased GH levels. Cimdelirsen also improved PRO, collectively supporting further development of this novel, liver-directed potential therapy for uncontrolled acromegaly.
    Clinical
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    SSTR (Somatostatin Receptor) • IGF1 (Insulin-like growth factor 1) • GHR (Growth Hormone Receptor 2)