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    GENE:

    GFPT1 (Glutamine--Fructose-6-Phosphate Transaminase 1)

    i
    Other names: GFPT1, Glutamine--Fructose-6-Phosphate Transaminase 1, GFAT1, GFAT, GFPT, GFA, Glutamine--Fructose-6-Phosphate Aminotransferase [Isomerizing] 1, Glutamine:Fructose-6-Phosphate Amidotransferase 1, D-Fructose-6-Phosphate Amidotransferase 1, Hexosephosphate Aminotransferase 1, GFAT 1, Glucosamine--Fructose-6-Phosphate Aminotransferase [Isomerizing] 1, Glutamine-Fructose-6-Phosphate Transaminase 1, CMSTA1, GFAT1m, GFPT1L, CMS12, MSLG
    Associations

    News

    Trials
    6ms
    GFAT1 promotes the progression of hepatocellular carcinoma via enhancing the O-GlcNAcylation of VEZF1. (PubMed, Cell Death Dis)
    This intervention effectively reduced TNS1 expression and suppressed the progression of HCC in a mouse model. Collectively, our findings underscore the therapeutic potential of targeting the GFAT1-VEZF1-TNS1 signaling axis in HCC.
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    GFPT1 (Glutamine--Fructose-6-Phosphate Transaminase 1)
    over3years
    Bladder Cancer-Derived Small Extracellular Vesicles Promote Tumor Angiogenesis by Inducing HBP-Related Metabolic Reprogramming and SerRS O-GlcNAcylation in Endothelial Cells. (PubMed, Adv Sci (Weinh))
    However, administration of GFAT1-overexpressing BCa cells-derived sEVs increase the angiogenetic activity in the ECs of GFAT1-knockout mice. In summary, this study suggests that inhibiting sEV-mediated GFAT1 secretion from BCa cells and targeting SerRS O-GlcNAcylation in ECs may serve as novel strategies for BCa antiangiogenetic therapy.
    Journal
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    GFPT1 (Glutamine--Fructose-6-Phosphate Transaminase 1)