Resolvin E1 Reduces Tumor Growth in a Xenograft Model of Lung Cancer. (PubMed, Am J Pathol)
RvE1 treatment led to a significant reduction of tumor volume and reduced expression of COX-2, NF-κB, VEGF-A, Ang-1, and Ang-2 when administered together with cisplatin. The data suggest that RvE1 prevents inflammation and vascularization, reduces tumor seeding and tumor size, and when used as an adjunct to chemotherapy, enhanced tumor reduction at significantly lower doses of cisplatin.