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    GENE:

    GDNF-AS1 (GDNF Antisense RNA 1)

    i
    Other names: GDNF-AS1, GDNF Antisense RNA 1, GDNFOS, GDNF Antisense RNA 1 (Head To Head), GDNF Opposite Strand, GDNF Antisense RNA 1 (Non-Protein Coding), NONHSAG040212.2, NONHSAG040215.2, NONHSAG040216.2, HSALNG0041256, HSALNG0041258, HSALNG0041262, Lnc-WDR70-7
    Associations

    News

    Trials
    3ms
    GDNF-AS1 mediated LHX2/METTL3/NCOA4 axis inhibits glioma progression via induction of ferroptosis. (PubMed, Neurochem Int)
    Mechanistically, GDNF-AS1 recruited transcription factor LHX2 to upregulate its enrichment at the METTL3 promoter, thereby suppressing METTL3 transcription, reducing N6-Methyladenosine (m6A) levels, promoting NCOA4 expression, and inducing ferroautophagy and ferroptosis in glioma cells. These findings demonstrate that GDNF-AS1 inhibits glioma development by activating ferroptosis through the LHX2/METTL3/NCOA4 axis.
    Journal
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    NCOA4 (Nuclear Receptor Coactivator 4) • GDNF-AS1 (GDNF Antisense RNA 1) • METTL3 (Methyltransferase Like 3)
    over2years
    Integrative analysis of multi-omics data reveals a pseudouridine-related lncRNA signature for prediction of glioma prognosis and chemoradiotherapy sensitivity. (PubMed, Comput Biol Med)
    Our study identified a four-lncRNA ΨrLs signature that effectively predicts the prognosis of glioma patients and may serve as a diagnostic tool. Risk scores of glioma patients generated by the signature is associated with immune-related biological processes and chemoradiotherapy sensitivity. These findings may inform the development of more targeted and effective therapies for glioma patients.
    Journal
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    EGFR (Epidermal growth factor receptor) • PTEN (Phosphatase and tensin homolog) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • GDNF-AS1 (GDNF Antisense RNA 1) • ZBTB20-AS4 (ZBTB20 Antisense RNA 4)
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    EGFR mutation
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    mitoxantrone
    over2years
    The prognostic value and immune landscaps of m6A/m5C-related lncRNAs signature in the low grade glioma. (PubMed, BMC Bioinformatics)
    Our study elucidated a prognostic prediction model of LGG by 8 m6A/m5C methylated lncRNAs and a critical lncRNA regulation function involved in LGG progression. High-risk patients have shorter survival times and a pro-tumor immune microenvironment.
    Journal
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    CD4 (CD4 Molecule) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • GDNF-AS1 (GDNF Antisense RNA 1) • LINC00665 (Long Intergenic Non-Protein Coding RNA 665) • RHPN1-AS1 (RHPN1 Antisense RNA 1)