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DRUG:

GCT02

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News alerts, weekly reports and conference planners

Company:

Myrio Therap

Drug class:

EGFRvIII-targeted CAR-T immunotherapy

Related drugs:

‹

CARv3-TEAM-E T cells (0)

multi-target gene-modified CAR-T/TCR-T cell immunotherapy (0)

CARv3-TEAM-E T cells (0)

multi-target gene-modified CAR-T/TCR-T cell immunotherapy (0)

›

over1year

Human EGFRvIII chimeric antigen receptor T cells demonstrate favorable safety profile and curative responses in orthotopic glioblastoma. (PubMed, Clin Transl Immunology)

Here, we show our de novo generated, high-affinity EGFRvIII-specific CAR; GCT02, demonstrating curative efficacy in human orthotopic glioblastoma models...This study demonstrates the preclinical functionality of a highly specific CAR targeting EGFRvIII on human cells. This CAR could be an effective treatment for glioblastoma and warrants future clinical investigation.

over 1 year ago

Journal • CAR T-Cell Therapy

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EGFR (Epidermal growth factor receptor)

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EGFR mutation

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GCT02