P1, N=84, Recruiting, Texas Tech University Health Sciences Center, El Paso | Trial completion date: Jan 2026 --> Jan 2028 | Trial primary completion date: Dec 2025 --> Dec 2027
4 days ago
Trial completion date • Trial primary completion date
To evaluate its prophylactic potential, WT mice were pretreated with CHR (20 and 40 mg/kg, i.g.) for three consecutive days prior to a single LPS injection (15 mg/kg, i.p.), while dexamethasone (2.5 mg/kg, i.p.) served as a positive control...CHR protects against LPS-induced AKI by inhibiting ferroptosis. This prophylactic process is linked to SIRT3-mediated deacetylation of NRF2, highlighting the potential of CHR as a preventive strategy for sepsis-induced renal injury.