^
    19h
    Evaluation of Vamorolone CYP3A4 Induction on Midazolam (a Sensitive CYP 3A4 Substrate) Pharmacokinetics (clinicaltrials.gov)
    P1, N=18, Completed, Santhera Pharmaceuticals
    New P1 trial
    |
    midazolam hydrochloride
    3d
    Inhaled Ciclesonide Study in Preterm Infants (clinicaltrials.gov)
    P1, N=30, Not yet recruiting, Children's Mercy Hospital Kansas City | Initiation date: Nov 2024 --> Feb 2025
    Trial initiation date
    3d
    Steroids and Pain Control After Tonsillectomy (clinicaltrials.gov)
    P2, N=150, Recruiting, Medical University of South Carolina | Trial completion date: Jul 2024 --> Jul 2025 | Trial primary completion date: Jul 2024 --> Jul 2025
    Trial completion date • Trial primary completion date
    3d
    Pulsed Radiofrequency Ablation and Steroid Injections for the Treatment of Meralgia Paresthetica (clinicaltrials.gov)
    P=N/A, N=22, Active, not recruiting, Ankara City Hospital Bilkent
    New trial
    |
    dexamethasone injection
    3d
    Intra-sheath vs Extra-sheath Injection for De Quervain's Tenosynovitis (clinicaltrials.gov)
    P4, N=80, Recruiting, University of California, Davis | Trial completion date: Jun 2024 --> Jun 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
    Trial completion date • Trial primary completion date
    |
    dexamethasone injection
    5d
    The efficacy and safety of glucocorticoid treatment by efficient delivery via the round window in total sudden deafness: an open-label, multicenter, superiority, randomized controlled trial (ChiCTR2400091078)
    P=N/A, N=298, Recruiting, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University; Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
    New trial • Head-to-Head
    |
    dexamethasone
    5d
    Study on the Safety and Efficacy of Perioperative Dexamethasone Administration in Hip and Knee Revision Arthroplasty (ChiCTR2400091108)
    P=N/A, N=500, Recruiting, West China Hospital, Sichuan University; West China Hospital, Sichuan University
    New trial
    |
    IL6 (Interleukin 6)
    |
    dexamethasone
    5d
    Diagnostic Value of ACTH Stimulation Test under 1mg dexamethasone suppression test in differentiating the Subtypes of Primary Aldosteronism (ChiCTR2400090753)
    P=N/A, N=0, Not yet recruiting, Department of Endocrinology, the First Medical Center, Chinese PLA General Hospital; the First Medical Center, Chinese PLA General Hospital
    New trial
    |
    dexamethasone
    5d
    Influence of ultrasound- guided quadratus lumborum block with dexamethasone and ropivacaine on postoperative pain in patients undergoing lower uterine cesarean section (ChiCTR2400089825)
    P=N/A, N=72, Not yet recruiting, Peking University Third Hospital Yanqing Hospital; Peking University Third Hospital Yanqing Hospital
    New trial
    |
    dexamethasone
    5d
    Application of ultrasound-guided proximal adductor combined with anse-foot tendon block in arthroscopic anterior cruciate ligament reconstruction of knee joint (ChiCTR2400089248)
    P=N/A, N=136, Recruiting, The First Affiliated Hospital of Guangxi Medical University; The First Affiliated Hospital of Guangxi Medical University
    New trial
    |
    dexamethasone
    5d
    Comparison of liposome bupivacaine and cocktail analgesic regimens for postoperative analgesia in Posterior cervical open-door laminoplasty: a prospective, double-blind, randomized controlled clinical study (ChiCTR2400089274)
    P4, N=100, Not yet recruiting, West China Hospital, Sichuan University; West China Hospital, Sichuan University
    New P4 trial
    |
    dexamethasone
    5d
    Comparison of liposome bupivacaine and cocktail analgesic regimens for postoperative analgesia in adolescent idiopathic scoliosis: a prospective, double-blind, randomized controlled clinical study (ChiCTR2400089287)
    P4, N=100, Not yet recruiting, West China Hospital, Sichuan University; West China Hospital,Sichuan University
    New P4 trial
    |
    dexamethasone
    5d
    A post-marketing study in Real-World of Fluocinolone Acetonide Intravitreal Insert in Patients With Chronic Noninfectious Uveitis Affecting the Posterior Segment of the Eye (ChiCTR2400091284)
    P4, N=126, Recruiting, Tianjin Medical University Eye Hospital; Ocumension Therapeuti Shanghai Ltd
    New P4 trial • Real-world evidence • Real-world
    5d
    Comparison of liposome bupivacaine and cocktail analgesic regimens for postoperative analgesia in Transforaminal lumbar interbody fusion: a prospective, double-blind, randomized controlled clinical study (ChiCTR2400089275)
    P4, N=100, Not yet recruiting, West China Hospital, Sichuan University; West China Hospital,Sichuan University
    New P4 trial
    |
    dexamethasone
    5d
    Comparative study on pharmacokinetics of fluticasone propionate cream in humans (ChiCTR2400090462)
    P1, N=12, Not yet recruiting, Huzhou Central Hospital; Zhejiang Xianju Pharmaceutical Co., Ltd.
    New P1 trial
    7d
    A Study of Low Dose Lenalidomide and Dexamethasone in Relapsed/Refractory Myeloma in Patients at High Risk for Myelosuppression (clinicaltrials.gov)
    P2, N=150, Completed, Peter MacCallum Cancer Centre, Australia | Unknown status --> Completed
    Trial completion
    |
    lenalidomide • dexamethasone • aspirin
    7d
    Different Treatment Modalities for Oral Lichen Plan (clinicaltrials.gov)
    P1, N=20, Completed, Al-Azhar University
    New P1 trial
    7d
    Comparison of Bupivacaine Liposomal vs Bupivacaine Combined With Dexamethasone for Postoperative Pain in VATS (clinicaltrials.gov)
    P=N/A, N=90, Recruiting, Affiliated Hospital of Jiaxing University | N=130 --> 90
    Enrollment change • Head-to-Head • Surgery
    |
    dexamethasone
    7d
    Hydrocortisone in Hormone Replacement Therapy for Large Pituitary Neuroendocrine Tumors (clinicaltrials.gov)
    P4, N=882, Not yet recruiting, Beijing Tiantan Hospital
    New P4 trial
    8d
    RESPONSE: NEXThaleR Real-world Study Assessing the EffectivenesS of BDP/FF/G Fixed triPle cOmbiNation on Symptom scorEs in COPD Patients (clinicaltrials.gov)
    P=N/A, N=1000, Active, not recruiting, Chiesi Hungary Ltd. | Recruiting --> Active, not recruiting | Trial completion date: Dec 2024 --> May 2025
    Enrollment closed • Trial completion date • Real-world evidence • Real-world
    8d
    STRENGTH: Investigation of Fixed Triple Inhaled Combination in Asthmatic Patients, in a Real-life Setting (clinicaltrials.gov)
    P=N/A, N=800, Recruiting, Chiesi Hungary Ltd.
    New trial
    9d
    A Multi-center Open Label Prospective Study on Early Initiation of Targeted-release Formulation of Budesonide in Patients With Primary IgA Nephropathy (clinicaltrials.gov)
    P=N/A, N=200, Not yet recruiting, Sichuan Provincial People's Hospital
    New trial
    9d
    ORESTES: Real-World Outcomes in COPD Patients Starting Trixeo (Budesonide/Glycopyrronium/Formoterol) in Spain. (clinicaltrials.gov)
    P=N/A, N=700, Recruiting, AstraZeneca | N=500 --> 700
    Enrollment change • Real-world evidence • Real-world
    10d
    Camel milk inhibits pulmonary oxidative stress and inflammation in a rat model of COPD induced by cigarette smoke exposure. (PubMed, Heliyon)
    In the COPD group treated with both doses of CM (dose dependently) and dexamethasone, almost all measured variables were significantly improved (p < 0.05 to p < 0.001). The potential effect of CM on lung inflammation and oxidative stress in a rat model of COPD comparable to dexamethasone was demonstrated.
    Preclinical • Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • CAT (Catalase)
    |
    dexamethasone
    11d
    An evaluation of the effects of glabridin and dexamethasone in bleomycin-induced pulmonary fibrosis: The role of BKCa channels. (PubMed, Tissue Cell)
    Our findings suggest that glabridin and Dex may exert anti-fibrotic effects by suppressing oxidative stress and inhibiting the inflammatory response, and that glabridin may improve pulmonary function through activation of BKCa channels. Both glabridin and Dex may therefore be of therapeutic use in pulmonary fibrosis.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha)
    |
    dexamethasone • bleomycin
    11d
    Pivotal Study of OCS-01 Eye Drops in Subjects with Diabetic Macular Edema (DIAMOND-2) (clinicaltrials.gov)
    P3, N=350, Recruiting, Oculis | Trial completion date: Dec 2025 --> Jun 2026 | Initiation date: Dec 2023 --> Mar 2024 | Trial primary completion date: Dec 2025 --> Jun 2026
    Trial completion date • Trial initiation date • Trial primary completion date
    14d
    COPED: Corticosteroids for Post-Extubation Dysphagia (clinicaltrials.gov)
    P2, N=80, Not yet recruiting, University of Colorado, Denver
    New P2 trial
    |
    methylprednisolone sodium succinate
    14d
    Intravenous and Perineural Dexamethasone for Brachial Plexus Block in Hand Surgery (clinicaltrials.gov)
    P1, N=108, Completed, Ohio State University | Recruiting --> Completed | Trial completion date: Jun 2024 --> Oct 2024 | Trial primary completion date: Jun 2024 --> Oct 2024
    Trial completion • Trial completion date • Trial primary completion date
    |
    dexamethasone • dexamethasone injection
    14d
    Efficacy of Self Vs. Physician Application of Triamcinolone-Econazole in Otomycosis (clinicaltrials.gov)
    P4, N=200, Completed, Zhongshan Hospital Xiamen University | Recruiting --> Completed
    Trial completion
    15d
    Clinical Study to Evaluate the Safety, Tolerability and the Concentration of the BDP (Beclomethasone Dipropionate), Active Metabolite of BDP, FF( Formoterol Fumarate) and GB (Glycopyrronium Bromide), After Inhalation of CHF 5993 at Two Different Doses and QVAR® (clinicaltrials.gov)
    P1, N=69, Completed, Chiesi Farmaceutici S.p.A. | Recruiting --> Completed
    Trial completion
    16d
    Ectopic ACTH-Dependent Cushing's Syndrome Emerging at a Late Stage of a Mixed Histology Neuroendocrine Neoplasm: A Case Report. (PubMed, Case Rep Oncol)
    Urinary free cortisol measurement was 21-fold the upper limit of the reference range (3,614.0 nmol/24 h), and cortisol concentration did not decrease after 1mg-dexamethasone suppression test (1,812 nmol/L for an expected value <50 nmol/L), confirming the ACTH-dependent CS...Hypercortisolism symptoms were effectively managed with an adrenal enzyme inhibitor (ketoconazole) in combination with somatostatin analogs...This redifferentiation phenomenon in neuroendocrine tumors should be further investigated as patients might be, under certain conditions, eligible for PRRT. Therefore, we suggest that newly occurring paraneoplastic syndromes in patients with NEC should always be evaluated using 68Ga-DOTATATE PET/CT.
    Journal
    |
    SSTR (Somatostatin Receptor)
    |
    SSTR Expression
    |
    dexamethasone
    16d
    Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination. (PubMed, Front Mol Neurosci)
    This inhibits the Smo-mediated canonical signaling while activating the Liver Kinase B1 (LKB1)/ AMP-activated protein kinase (AMPK) pathway, leading to Myelin basic protein (MBP) expression. These insights pave the way for pharmacological targeting of Smo CRD to enhance oligodendrocyte precursor cells (OPCs) differentiation and improve remyelination.
    Preclinical • Journal
    |
    STK11 (Serine/threonine kinase 11)
    16d
    OLE_NEAT: Open-Label Extension of EryDex Study IEDAT-04-2022 (clinicaltrials.gov)
    P3, N=106, Not yet recruiting, Quince Therapeutics S.p.A.
    New P3 trial
    16d
    Topical Treatment for Atopic Dermatitis (clinicaltrials.gov)
    P=N/A, N=30, Recruiting, Wake Forest University Health Sciences | Not yet recruiting --> Recruiting
    Enrollment open
    17d
    Pharmacokinetic Profile and Safety of Fluticasone Propionate and Albuterol Sulfate in Combination When Compared to Fluticasone Propionate Multidose Dry Powder Inhaler (Fp MDPI) in Children Aged 4 to 11 Years Old (clinicaltrials.gov)
    P1, N=30, Completed, Teva Branded Pharmaceutical Products R&D, Inc. | Recruiting --> Completed | N=22 --> 30
    Trial completion • Enrollment change
    17d
    Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine in Bilevel Erector Spinae Plane Block in Breast Surgeries (clinicaltrials.gov)
    P=N/A, N=68, Completed, National Cancer Institute, Egypt | Recruiting --> Completed
    Trial completion • Surgery
    |
    dexamethasone
    18d
    Erector Spinae Plan Block (ESPB) with Dexmedetomidine and Dexamethasone in Lumbar Spine Fusion (clinicaltrials.gov)
    P4, N=46, Not yet recruiting, University of Southern California
    New P4 trial
    |
    dexamethasone
    18d
    COSMIC: Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients (clinicaltrials.gov)
    P3, N=100, Recruiting, St. Joseph's Healthcare Hamilton | Trial completion date: Nov 2024 --> May 2025 | Trial primary completion date: May 2024 --> Apr 2025
    Trial completion date • Trial primary completion date
    |
    dexamethasone injection
    22d
    Verification of the Efficacy/safety of the Intratympanic Drug Delivery for Hearing Loss (clinicaltrials.gov)
    P1/2, N=15, Completed, Seoul National University Hospital | Recruiting --> Completed | N=26 --> 15
    Trial completion • Enrollment change
    |
    dexamethasone
    22d
    Assessment and Comparison of Efficacy of Intra-Articular PRP and Corticosteroid in First CMC Joint OA Treatment (clinicaltrials.gov)
    P4, N=60, Completed, Antalya Training and Research Hospital
    New P4 trial
    |
    methylprednisolone acetate
    22d
    Mutual associations among responsiveness to differential diagnostic tests for Cushing's disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumors. (PubMed, Endocr J)
    In 27 hospitalized patients with CD at Osaka University Hospital, Osaka, Japan, associations between corticotroph tumor diameter, the response of ACTH and cortisol to differential diagnostic tests for CD (CRH, desmopressin [DDAVP], and high-dose dexamethasone suppression test [HDDST]), the ACTH/cortisol index, and the SSTR5 immunoreactive score were retrospectively investigated. Tests for differential diagnosis of CD, the ACTH/cortisol index, and the corticotroph tumor diameter have the potential for identifying SSTR5 expression in corticotroph tumors. These parameters may reflect the biological characteristics of corticotroph tumors.
    Journal
    |
    SSTR (Somatostatin Receptor) • SSTR5 (Somatostatin Receptor 5)
    |
    SSTR5 expression • SSTR Expression
    |
    dexamethasone
    23d
    Inflammatory profile of eosinophils in asthma-COPD overlap and eosinophilic COPD: a multi-omics study. (PubMed, Front Immunol)
    Atorvastatin, dexamethasone, and PGE2 differentially modulated these inflammatory changes. ACO/eCOPD is associated with viral infection and an inflammatory milieu. Therapeutic strategies using statins and inhaled corticosteroids are recommended to control these pathogenic changes.
    Journal
    |
    IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • FCER1G (Fc Fragment Of IgE Receptor Ig) • IL5 (Interleukin 5) • IL33 (Interleukin 33)
    |
    dexamethasone • atorvastatin