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    BIOMARKER:

    GBP5 overexpression

    i
    Other names: GBP5, Guanylate Binding Protein 5, Guanine Nucleotide-Binding Protein 5, Guanylate-Binding Protein 5, GTP-Binding Protein 5, GBP-TA Antigen, GBP-5
    Entrez ID:
    115362
    Related biomarkers:
    Expression
    almost2years
    The XPO1 inhibitor selinexor ameliorates bleomycin-induced pulmonary fibrosis in mice via GBP5/NLRP3 inflammasome signaling. (PubMed, Int Immunopharmacol)
    Taken together, our findings indicate that Sel ameliorates BLM-induced pulmonary fibrosis by targeting GBP5 via NLRP3 inflammasome signaling. Thus, the XPO1 inhibitor - Sel might be a potential therapeutic agent for pulmonary fibrosis.
    Preclinical • Journal • IO biomarker
    |
    FGF2 (Fibroblast Growth Factor 2) • IL18 (Interleukin 18) • TGFB1 (Transforming Growth Factor Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • GBP5 (Guanylate Binding Protein 5) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • CTGF (Connective tissue growth factor)
    |
    GBP5 expression • GBP5 overexpression
    |
    Xpovio (selinexor) • bleomycin
    almost2years
    The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis. (PubMed, J Orthop Translat)
    This study underscores the significance of the IRF1/GBP5 axis in NLRP3 inflammasome-mediated chondrocyte pyroptosis and osteoarthritic chondrocyte injury. Modulating IRF1 and GBP5 expression could serve as a novel therapeutic target for OA.
    Journal
    |
    IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • IL18 (Interleukin 18) • IRF1 (Interferon Regulatory Factor 1) • GBP5 (Guanylate Binding Protein 5) • MMP9 (Matrix metallopeptidase 9) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • ACAN (Aggrecan) • COL2A1 (Collagen Type II Alpha 1 Chain)
    |
    IRF1 expression • GBP5 expression • GBP5 overexpression