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    BIOMARKER:

    GBP5 expression

    i
    Other names: GBP5, Guanylate Binding Protein 5, Guanine Nucleotide-Binding Protein 5, Guanylate-Binding Protein 5, GTP-Binding Protein 5, GBP-TA Antigen, GBP-5
    Entrez ID:
    115362
    Related biomarkers:
    Expression
    1year
    Knockdown of GBP5 alleviates renal damage caused by psoriasis by regulating NF-κB/STAT3 pathway. (PubMed, Allergol Immunopathol (Madr))
    Inhibiting GBP5 can mitigate the renal injury caused by psoriasis through NF-κB/STAT3 axix.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • STAT3 (Signal Transducer And Activator Of Transcription 3) • GBP5 (Guanylate Binding Protein 5)
    |
    GBP5 expression
    |
    Zyclara (imiquimod)
    almost2years
    The XPO1 inhibitor selinexor ameliorates bleomycin-induced pulmonary fibrosis in mice via GBP5/NLRP3 inflammasome signaling. (PubMed, Int Immunopharmacol)
    Taken together, our findings indicate that Sel ameliorates BLM-induced pulmonary fibrosis by targeting GBP5 via NLRP3 inflammasome signaling. Thus, the XPO1 inhibitor - Sel might be a potential therapeutic agent for pulmonary fibrosis.
    Preclinical • Journal • IO biomarker
    |
    FGF2 (Fibroblast Growth Factor 2) • IL18 (Interleukin 18) • TGFB1 (Transforming Growth Factor Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • GBP5 (Guanylate Binding Protein 5) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • CTGF (Connective tissue growth factor)
    |
    GBP5 expression • GBP5 overexpression
    |
    Xpovio (selinexor) • bleomycin
    almost2years
    The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis. (PubMed, J Orthop Translat)
    This study underscores the significance of the IRF1/GBP5 axis in NLRP3 inflammasome-mediated chondrocyte pyroptosis and osteoarthritic chondrocyte injury. Modulating IRF1 and GBP5 expression could serve as a novel therapeutic target for OA.
    Journal
    |
    IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • IL18 (Interleukin 18) • IRF1 (Interferon Regulatory Factor 1) • GBP5 (Guanylate Binding Protein 5) • MMP9 (Matrix metallopeptidase 9) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • ACAN (Aggrecan) • COL2A1 (Collagen Type II Alpha 1 Chain)
    |
    IRF1 expression • GBP5 expression • GBP5 overexpression
    almost2years
    Guanylate binding protein 5 triggers NF-κB activation to foster radioresistance, metastatic progression and PD-L1 expression in oral squamous cell carcinoma. (PubMed, Clin Immunol)
    Importantly, GBP5 upregulation predicted a favorable outcome in cancer patients received ICI treatment. Our findings provide GBP5 as a useful biomarker to predict the anti-OSCC effectiveness of irradiation and ICIs.
    Journal • PD(L)-1 Biomarker • IO biomarker • Metastases
    |
    PD-L1 (Programmed death ligand 1) • GBP5 (Guanylate Binding Protein 5)
    |
    PD-L1 expression • GBP5 expression
    2years
    A Synthetic Steroid 5α-Androst-3β, 5, 6β-triol Alleviates Radiation-Induced Brain Injury in Mice via Inhibiting GBP5/NF-κB/NLRP3 Signal Axis. (PubMed, Mol Neurobiol)
    In summary, TRIOL effectively alleviate RIBI by inhibiting the GBP5/NF-κB/NLRP3 signal axis, reducing microglia activation and pro-inflammation cytokines release, rescuing neuron loss. This study highlights the potential of TRIOL as a novel and promising therapy drug for RIBI treatment.
    Preclinical • Journal
    |
    GBP5 (Guanylate Binding Protein 5) • NLRP3 (NLR Family Pyrin Domain Containing 3)
    |
    GBP5 expression
    2years
    GBP5 Expression Predicted Prognosis of Immune Checkpoint Inhibitors in Small Cell Lung Cancer and Correlated with Tumor Immune Microenvironment. (PubMed, J Inflamm Res)
    In this study, we found that GBP5 has the potential to be used as a biomarker of ICIs efficacy for SCLC patients. GBP5 is related to the quantity of inflammatory molecules, a high level of immune infiltration, and a highly activated immune response pathway.
    Journal • Checkpoint inhibition • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • GBP5 (Guanylate Binding Protein 5)
    |
    GBP5 expression