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    GENE:

    GBP3 (Guanylate Binding Protein 3)

    i
    Other names: GBP3, Guanylate Binding Protein 3, Guanine Nucleotide-Binding Protein 3, Guanylate-Binding Protein 3, GTP-Binding Protein 3, FLJ10961, Guanylate-Binding Protein 3 Delta C, GBP-3
    Associations

    News

    Trials
    almost3years
    The function of guanylate binding protein 3 (GBP3) in human cancers by pan-cancer bioinformatics. (PubMed, Math Biosci Eng)
    Moreover, the most frequent mutation sites of GBP3 in cancers are R151Q/* and K380N. This study would provide new insight into cancer prognosis and therapy.
    Journal • Pan tumor
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    CD8 (cluster of differentiation 8) • GBP3 (Guanylate Binding Protein 3)
    over3years
    Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response. (PubMed, Front Genet)
    The GBP5-related prognostic model we constructed in CRC can predict the survival of patients and propose some genes for subsequent research. This study revealed a strong correlation between GBP5 and immunity in generalized cancer and provided evidence that CRC may be a suitable cancer type for anti-GBP5 therapy.
    Journal • IO biomarker
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    GBP3 (Guanylate Binding Protein 3)
    over3years
    GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair. (PubMed, Oncogene)
    Clinically, GBP3 expression is high and positively correlated with STING, NRF2, p62, and MGMT expression in human glioblastoma tumors, and is associated with poor outcomes. These findings provide novel insight into TMZ resistance and suggest that GBP3 may represent a novel potential target for the treatment of glioblastoma.
    Journal
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    MGMT (6-O-methylguanine-DNA methyltransferase) • SQSTM1 (Sequestosome 1) • STING (stimulator of interferon response cGAMP interactor 1) • GBP3 (Guanylate Binding Protein 3)
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    temozolomide