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    BIOMARKER:

    GATA2 mutation

    i
    Other names: GATA2, GATA Binding Protein 2, Endothelial Transcription Factor GATA-2, GATA-Binding Protein 2, MONOMAC, IMD21, NFE1B, DCML
    Entrez ID:
    2624
    Related biomarkers:
    Mutation
    11ms
    Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations (clinicaltrials.gov)
    P2, N=144, Recruiting, National Cancer Institute (NCI) | Trial completion date: Dec 2025 --> Dec 2028 | Trial primary completion date: Dec 2024 --> Dec 2027
    Trial completion date • Trial primary completion date
    |
    GATA2 (GATA Binding Protein 2)
    |
    GATA2 mutation
    |
    cyclophosphamide • fludarabine IV • busulfan
    1year
    Analysis of Clinical Characteristics and Prognosis of AML Patients with Co-Mutation of CEBPA Gene and GATA2 Gene (PubMed, Zhongguo Shi Yan Xue Ye Xue Za Zhi)
    The median age of patients with GATA2 gene mutation is lower than that of patients without GATA2 gene mutation. GATA2 gene mutation further prolongs the survival time of AML patients with CEBPA double mutations and CEBPA-bZIP domain mutation.
    Journal
    |
    CEBPA (CCAAT Enhancer Binding Protein Alpha) • GATA2 (GATA Binding Protein 2)
    |
    CEBPA mutation • GATA2 mutation
    over1year
    Clinical Characteristics and Prognosis of Acute Myeloid Leukemia Patients with GATA2 Gene Mutation (PubMed, Zhongguo Shi Yan Xue Ye Xue Za Zhi)
    GATA2 mutation is more common in AML patients with normal karyotype and low-risk cytogenetic stratification, and it is significantly associated with CEBPAdm and NRAS co-mutations. The prognostic significance of GATA2 is influenced by CEBPAdm. The choice of "3+7" or "DCAG" induction regimen in patients with GATA2 mutation does not affect their CR rate, while the choice of allo-HSCT can significantly improved the prognosis compared with chemotherapy only.
    Retrospective data • Journal
    |
    FLT3 (Fms-related tyrosine kinase 3) • NRAS (Neuroblastoma RAS viral oncogene homolog) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • NPM1 (Nucleophosmin 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • WT1 (WT1 Transcription Factor) • GATA2 (GATA Binding Protein 2)
    |
    NRAS mutation • GATA2 mutation
    almost2years
    GATA2 mutant variant allele frequency may reflect prognosis in Chinese adult patients with de novo cytogenetically normal acute myeloid leukemia. (PubMed, Biomol Biomed)
    In the intermediate-risk group, the high median VAF of GATA2 (≥38.51%) had no significant effect in OS and RFS compared with the low median VAF (<38.51%). This study offers new insights on the prognosis of GATA2mut in the favorable-risk group, where VAF can be used as a guide.
    Journal
    |
    WT1 (WT1 Transcription Factor) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • GATA2 (GATA Binding Protein 2)
    |
    CEBPA mutation • WT1 mutation • GATA2 mutation
    almost2years
    Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations (clinicaltrials.gov)
    P2, N=144, Recruiting, National Cancer Institute (NCI) | Trial completion date: Dec 2024 --> Dec 2025
    Trial completion date
    |
    GATA2 (GATA Binding Protein 2)
    |
    GATA2 mutation
    |
    cyclophosphamide • fludarabine IV • busulfan
    almost2years
    Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations (clinicaltrials.gov)
    P2, N=144, Recruiting, National Cancer Institute (NCI) | Trial primary completion date: Dec 2023 --> Dec 2024
    Trial primary completion date
    |
    GATA2 (GATA Binding Protein 2)
    |
    GATA2 mutation
    |
    cyclophosphamide • fludarabine IV • busulfan
    almost2years
    Linking GATA2 to myeloid dysplasia and complex cytogenetics in adult myelodysplastic neoplasm and acute myeloid leukemia. (PubMed, Blood Adv)
    However, the percent of GATA2+ blasts in AML is highly variable. Elevated GATA2 expression in AML blasts correlates with peripheral neutropenia and complex AML cytogenetics but, unlike in MDS, does not predict survival.
    Journal
    |
    CDH1 (Cadherin 1) • CD34 (CD34 molecule) • GATA2 (GATA Binding Protein 2)
    |
    GATA2 mutation
    almost2years
    Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904) (clinicaltrials.gov)
    P2, N=40, Recruiting, Fred Hutchinson Cancer Center
    Trial completion date • Trial primary completion date
    |
    HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) • HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1) • GATA2 (GATA Binding Protein 2) • HLA-B (Major Histocompatibility Complex, Class I, B) • HLA-C (Major Histocompatibility Complex, Class I, C)
    |
    LDH elevation • GATA2 mutation
    |
    methotrexate • fludarabine IV • busulfan • Grafapex (treosulfan) • methotrexate IV
    2years
    Clinical Features of Myeloid Neoplasms with Germline GATA2 Mutations–a Systematic Review of Clinical Studies Retrieved through Extensive Searching (ASH 2023)
    Most of germline GATA2 mutation carriers will have symptoms in young age and many of them will progress into malignant myeloid diseases. Allo-HSCT was effective to treat symptomatic patients, especially for patients with malignant hematologic diseases, and furthermore that is the only curative treatment. Asymptomatic carriers are not rare and for them regular tests are essential.
    Clinical • Review
    |
    GATA2 (GATA Binding Protein 2)
    |
    GATA2 mutation
    2years
    The role of GATA2 in adult hematopoiesis and cell fate determination. (PubMed, Front Cell Dev Biol)
    The detailed description of how GATA2 regulates HSC maintenance and blood lineage determination is crucial to unravel the pathogenesis of GATA2 deficiency syndrome. In this review, we summarize current advances in elucidating the role of GATA2 in hematopoietic cell fate determination and discuss the challenges of modeling GATA2 deficiency syndrome.
    Review • Journal
    |
    GATA2 (GATA Binding Protein 2)
    |
    GATA2 mutation
    2years
    Linking GATA2 to Myeloid Dysplasia and Complex Cytogenetics in Adult Myelodysplastic Neoplasm and Acute Myeloid Leukemia. (PubMed, Blood Adv)
    However, percent of GATA2+ blasts in AML is highly variable. Elevated GATA2 expression in AML blasts correlates with peripheral neutropenia and complex AML cytogenetics but unlike in MDS does not predict survival.
    Journal
    |
    CDH1 (Cadherin 1) • CD34 (CD34 molecule) • GATA2 (GATA Binding Protein 2)
    |
    GATA2 mutation