^
Contact us  to learn more about
our Premium Content:  News alerts, weekly reports and conference planners
BIOMARKER:

GATA1 overexpression

i
Other names: GATA1, GATA Binding Protein 1, Erythroid Transcription Factor, Globin Transcription Factor 1, Nuclear Factor, Erythroid 1, NF-E1 DNA-Binding Protein, GATA-Binding Factor 1, GATA-1, ERYF1, GF-1, GF1, GATA-Binding Protein 1 (Globin Transcription Factor 1), Erythroid Transcription Factor 1, Transcription Factor GATA1, NF-E1, XLANP, XLTDA, Eryf1, NFE1, XLTT
Entrez ID:
8ms
CRISPR screen identifies GATAD1 as a synthetic lethal target with CDK4/6 inhibitors in estrogen receptor-positive breast cancer. (PubMed, Med Oncol)
P21 overexpression abolished the enhanced proliferation induced by GATAD1 overexpression. Our results identify GATAD1 as a therapeutic target in ER breast cancer, which is beneficial to provide a novel treatment strategy.
Journal • Synthetic lethality
|
ER (Estrogen receptor) • RB1 (RB Transcriptional Corepressor 1) • GATA1 (GATA Binding Protein 1)
|
ER positive • GATA1 overexpression
11ms
ARHGAP18 is Upregulated by Transcription Factor GATA1 Promotes the Proliferation and Invasion in Hepatocellular Carcinoma. (PubMed, Appl Biochem Biotechnol)
Further studies revealed that the effects of ARHGAP18 silencing on HCCLM3 and Bel-7402 cells were blocked by GATA1 overexpression. In conclusion, GATA1-mediated ARHGAP18 up-regulation plays an important role in HCC tumorigenesis and might be a potential therapeutic target for HCC.
Journal
|
GATA1 (GATA Binding Protein 1)
|
GATA1 overexpression
almost1year
Over-Expressed GATA-1, the Short Isoform of the Hematopoietic Transcriptional Factor GATA-1, Inhibits Ferroptosis in K562 Myeloid Leukemia Cells by Preventing Lipid Peroxidation. (PubMed, Antioxidants (Basel))
Targeting ferroptosis is a promising strategy to overcome chemoresistance. Therefore, our results could provide novel potential therapeutic approaches and targets to overcome drug resistance in hematological malignancies.
Journal
|
GPX4 (Glutathione Peroxidase 4) • GATA1 (GATA Binding Protein 1)
|
GATA1 overexpression
1year
Effect of GATAD1 regulating the SRRM2 gene on recurrence of thyroid tumor and its molecular mechanism. (PubMed, Gland Surg)
We identified GATAD1 as an underlying diagnostic biomarker in THCA recurrence patients. The GATAD1-SRRM2 axis mediates human THCA recurrence progression and is an underlying target for THCA treatment.
Journal
|
GATA1 (GATA Binding Protein 1)
|
GATA1 overexpression
over2years
Exploring the Leukemogenic Potential of GATA-1, the Shorter Isoform of GATA-1: Novel Insights into Mechanisms Hampering Respiratory Chain Complex II Activity and Limiting Oxidative Phosphorylation Efficiency. (PubMed, Antioxidants (Basel))
Abnormal levels of GATA-1 and SDHC variants were also found in an acute myeloid leukemia patient, thus supporting in vitro results. A better understanding of these mechanisms can contribute to identify novel promising therapeutic targets in myeloid leukemia.
Journal
|
GATA1 (GATA Binding Protein 1) • SDHC (Succinate Dehydrogenase Complex Subunit C)
|
GATA1 overexpression
over3years
GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells. (PubMed, Arch Virol)
Collectively, these data indicated that GATA1/SP1 and miR-874 mediate EV71-induced apoptosis in a granzyme B-dependent manner. This signaling pathway may provide a new pharmacological target for the prevention and treatment of HFMD.
Journal
|
BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • GZMB (Granzyme B) • GATA1 (GATA Binding Protein 1)
|
BAX expression • GATA1 overexpression