GAST (Gastrin 2)

Efficacy studies revealed a reduction in mean tumor volume of up to 65% in two independent orthotopic mouse models, with no tumor evident in some of the animals treated with the CCK2p-boundPAPTP construct. Our data suggest that tumor-specific targeting of small molecules may be a promising strategy for precision medicine against PDAC.

Fifty-six mice were randomly allocated into four groups, including control, diabetic constipation (DC), disulfiram, and propargylglycine (PAG)...The results of this study demonstrated that H2S is an effective and key factor in regulating colonic motility in mice with DC. In the future, inhibitors of H2S production may be used to manage the digestive complications associated with DC.

Together, these multi-level data indicate that RQCJ exerts clinically relevant protection against CAG via multi-component suppression of TNF-NF-κB/Caspase-3 axis, broad rebalancing of pro-/anti-inflammatory cytokines, and restoration of gastric function.

Recurrent GI bleeding in ZES requires a coordinated approach integrating medical, endoscopic, and surgical therapies. Early recognition is essential to prevent severe complications, and a high index of suspicion is warranted in patients with refractory PUD, chronic diarrhoea, or unexplained GI bleeding.

P=N/A, N=162, Recruiting, Beijing University of Traditional Chinese Medicine; Beijing University of Traditional Chinese Medicine

P4, N=1500, Not yet recruiting, Maternal and Child Health Hospital of Hubei Province; Maternal and Child Health Hospital of Hubei Province

P4, N=134, Not yet recruiting, Shunde Hospital, Guangzhou University of Chinese Medicine; Shunde Hospital, Guangzhou University of Chinese Medicine

The bioactive compounds of nopal engage multiple biological pathways relevant to T2D and CRC, suggesting that this plant may serve as a promising pharmacological candidate for the management of these diseases.

For patients with SP and gastrointestinal dysfunction, early IMV initiation within 6 hours is more effective in mitigating systemic inflammation, improving blood gas exchange and gastrointestinal function, optimizing infection control, reducing adverse events, and ultimately improving clinical prognosis.

He was referred for parathyroidectomy followed by total pancreatectomy with duodenectomy, while first-degree relatives were offered genetic screening. This case highlights the diagnostic complexity of MEN1 in the absence of a family history, in which gastrointestinal ulcerations with bleeding, fleeting thrombophlebitis, and hypercalcemia may serve as early clinical clues.

In addition, GLSP significantly alleviated the abnormal spleen tissue structure, promoted tumor tissue necrosis, lowered the serum levels of inflammatory factors [interleukin(IL)-1β, tumor necrosis factor(TNF)-α)], increased CD4~+ expression in the spleen tissue, reduced CD8~+ expression, and down-regulated the protein and mRNA levels of JAK2/STAT3 pathway-related factors in model mice. To sum up, GLSP can inhibit Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3) activation by reducing IL-6 expression, raise the CD4~+/CD8~+ level, regulate the tumor microenvironment, enhance immunity, improve gastrointestinal absorption and digestion, promote energy metabolism, and increase the skeletal muscle energy storage level, thereby relieving cancer-related fatigue in mice with the spleen deficiency syndrome.

lucidum spores increased thymus index, spleen index, elevated immunoglobulin A(IgA), immunoglobulin M(IgM), and immunoglobulin G(IgG) levels, decreased interleukin-6(IL-6), interleukin-1 beta(IL-1β), and tumor necrosis factor-α(TNF-α) levels, and improved splenic histopathological changes. The above results indicate that G. lucidum spores can improve the physical signs and behavior, digestive function, energy metabolism, and immune regulation of mice with spleen deficiency and have the medicinal properties of spleen meridian tropism and efficacy of strengthening the spleen.