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    BIOMARKER:

    GAST expression

    i
    Other names: GAST, Gastrin 2, Preprogastrin, GAS
    Entrez ID:
    2520
    2years
    Therapeutic target biomarkers of patient-derived xenograft models of gastric-type cervical adenocarcinoma. (PubMed, Gynecol Oncol Rep)
    In summary, we evaluated biomarkers for therapeutic targets using newly established PDX models of GAS. Frequent HER3 overexpression and HER2 expression in GAS tumors suggest the possibility of new treatments for patients with GAS by targeting HER3 and HER2.
    Preclinical • Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • ARID1A (AT-rich interaction domain 1A) • MSH6 (MutS homolog 6) • PMS2 (PMS1 protein homolog 2)
    |
    HER-2 overexpression • ERBB3 expression • ERBB3 overexpression • GAST expression
    over2years
    Marked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation. (PubMed, J Gastroenterol)
    AIG induces diverse trans-differentiation in the gastric mucosa, characterized by the transactivation of genes specific to the small intestine, pancreas, and lung. Increased environmental pH owing to AIG may cause abnormal differentiation of the gastric mucosa.
    Journal
    |
    PAPPA2 (Pappalysin 2) • NKX2-1 (NK2 Homeobox 1) • CTRC (Chymotrypsin C)
    |
    GAST expression
    over2years
    Gastrodin synergistically increases migration of interleukin-13 receptor α2 chimeric antigen receptor T cell to the brain against glioblastoma multiforme: A preclinical study. (PubMed, Phytother Res)
    Transcriptomic analysis revealed that genes related to skeletal migration such as add2 and gng8 showed increased expression in GAS-treated CAR-T cells. We found that GAS synergistically improves the mobility of IL-13Rα2 CAR-T, enhancing their ability to recognize the tumor antigen of glioblastoma, which could be advantageous for the application of CAR-T for the treatment of solid tumors.
    Preclinical • Journal • CAR T-Cell Therapy • IO biomarker
    |
    IL13 (Interleukin 13)
    |
    GAST expression
    over2years
    Evaluation of Gas 6 as a Prognostic Marker in Papillary Renal Cell Carcinoma. (PubMed, Urol Int)
    Gas 6 was not found to be an independent prognostic marker in pRCC. Future studies are warranted to determine if Gas 6 plays a role as prognostic marker or therapeutic target in pRCC.
    Journal
    |
    GAS6 (Growth arrest specific 6)
    |
    GAST expression