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DRUG:

ultra-high concentration nitric oxide (UNO101)

i
Other names: UNO101, UNO, gNO
Associations
Trials
Company:
Beyond Air
Drug class:
Immunostimulant, Guanylate cyclase stimulant, Nitric oxide donor
Related drugs:
Associations
Trials
3ms
A Study to Assess the Safety and Efficacy of Nitric Oxide Injection Into Unresectable Solid Primary or Metastatic Tumors (clinicaltrials.gov)
P1, N=38, Recruiting, Beyond Air Inc. | Trial completion date: Apr 2025 --> Jun 2025 | Trial primary completion date: Jul 2024 --> May 2025
Trial completion date • Trial primary completion date • Metastases
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ultra-high concentration nitric oxide (UNO101)
7ms
A Study to Assess the Safety and Efficacy of Nitric Oxide Injection Into Unresectable Solid Primary or Metastatic Tumors (clinicaltrials.gov)
P1, N=38, Recruiting, Beyond Air Inc. | Trial completion date: Jul 2024 --> Apr 2025 | Trial primary completion date: Dec 2023 --> Jul 2024
Trial completion date • Trial primary completion date • Metastases
|
ultra-high concentration nitric oxide (UNO101)
1year
Intratumoral Administration of High-Concentration Nitric Oxide and Anti-mPD-1 Treatment Improves Tumor Regression Rates and Survival in CT26 Tumor-Bearing Mice. (PubMed, Cells)
Combining high-concentration NO and immune checkpoint inhibitors warrants further assessment especially in tumors resistant to checkpoint inhibitor therapy.
Preclinical • Journal • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8)
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PD-L1 expression
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ultra-high concentration nitric oxide (UNO101)
over2years
Single intra-tumoral injection of gaseous nitric oxide induces an adaptive immune response in a mouse CT-26 solid tumor model (AACR 2022)
Intra-tumoral injection of ultra-high doses of NO at 20,000 and 50,000 ppm gNO led to an increased recruitment and concentration of T and B cells. Additionally, 50,000 ppm NO led to an increase of lymphocyte infiltration to the tumor. Taken together, the data suggest that the increase in lymphocyte infiltration, B and T cell population, and the reduction of MDSCs, are indicative of an adaptive immune response that results in rejection of secondary tumors in gNO-treated mice.
Preclinical
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IFNG (Interferon, gamma)
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IFNG expression
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ultra-high concentration nitric oxide (UNO101)