GAS7 (Growth Arrest Specific 7)

A panel of four serum miRNAs (hsa-miR-107, hsa-miR-146a-5p, hsa-miR-15b-5p, and hsa-miR-218-5p) exhibits high specificity and sensitivity. It shows potential as an efficient, non-invasive, and cost-effective biomarker for BC screening.

Additionally, DBNDD1 knockdown resulted in reduced tumor growth in vivo, highlighting that DBNDD1-GDF15-NF-κB signaling pathway drives CRC pathogenesis. Implications: This study highlights the crucial role of the DBNDD1/GDF15/NF-κB signaling pathway in CRC development, positioning DBNDD1 as a promising target for precision medicine strategies aimed at enhancing patient outcomes.

In conclusion, our experiments suggested that OCSCs-derived exosomes enhanced OC cisplatin resistance by suppressing GAS7 through the delivery of miR-4516. This study provides a possible target for the treatment of OC DDP resistance.

In addition, GAS7 expression in NSCLC patients may be positively related with the infiltration of immune cell subsets in tumor microenvironment (TME). The axis of METTL3-miR-196a-GAS7 might be a target for molecular targeted therapy, a potential and novel diagnostic marker for NSCLC patients.

It was also observed that the Sp1/Gas7/PI3K/Akt axis was critical for malignant phenotype and oxaliplatin sensitivity in HCC. Therefore, Gas7 can be considered as a prognostic predictor and therapeutic target for HCC.

Downregulation of Circzfp644 and Gas7 and upregulation of miR-20-5p were found in human NTD tissue. This study provides new perspectives on the role of circRNAs in nervous system development and the pathogenesis of NTDs.

Our aim was to explore the involvement of circ_0078607 in OC cell cisplatin (DDP) resistance and its potential mechanisms...Circ_0078607 stability was assessed by ribonuclease R digestion and actinomycin D treatment...Finally, circ_0078607 improved the sensitivity of DDP in vivo. Circ_0078607 attenuates DDP resistance via miR-196b-5p/GAS7 axis, which highlights the therapeutic potential of circ_0078607 to counter DDP resistance in OC.

The integrative analysis revealed 58 genes exhibited both somatic mutation and dysregulated mRNA levels in high metastatic cells. Altogether, metastatic drivers could accumulate gradually at different stages during HCC progression, some drivers might modulate HCC metastatic potentials and the others regulate metastatic tropisms.