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    BIOMARKER:

    GAS7 overexpression

    i
    Other names: GAS7, Growth Arrest Specific 7, Growth Arrest-Specific Protein 7, KIAA0394, MGC1348, GAS-7
    Entrez ID:
    8522
    almost3years
    Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer. (PubMed, Epigenetics)
    Our aim was to explore the involvement of circ_0078607 in OC cell cisplatin (DDP) resistance and its potential mechanisms...Circ_0078607 stability was assessed by ribonuclease R digestion and actinomycin D treatment...Finally, circ_0078607 improved the sensitivity of DDP in vivo. Circ_0078607 attenuates DDP resistance via miR-196b-5p/GAS7 axis, which highlights the therapeutic potential of circ_0078607 to counter DDP resistance in OC.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • ABCB1 (ATP Binding Cassette Subfamily B Member 1) • GAS7 (Growth Arrest Specific 7) • MIR196B (MicroRNA 196b)
    |
    GAS7 overexpression
    |
    cisplatin • dactinomycin