News - GAS6 overexpression

3years

GAS6-AS1 Overexpression Increases GIMAP6 Expression and Inhibits Lung Adenocarcinoma Progression by Sponging miR-24-3p. (PubMed, Front Oncol)

Down-expressed GAS6-AS1 acted as a sponge for miR-24-3p and down-regulated the expression of its target, GTPase IMAP Family Member 6. These findings suggested that GAS6-AS1 might represent a potential diagnostic biomarker for LUAD.

3 years ago

Journal

GAS6 (Growth arrest specific 6)

GAS6 overexpression

over3years

lncRNA GAS6-AS1 inhibits progression and glucose metabolism reprogramming in LUAD via repressing E2F1-mediated transcription of GLUT1. (PubMed, Mol Ther Nucleic Acids)

Taken together, our results identified GAS6-AS1 as a novel tumor suppressor in LUAD and unraveled its underlying molecular mechanism in reprogramming glucose metabolism. GAS6-AS1 potentially may serve as a prognostic marker and therapeutic target in LUAD.

over 3 years ago

Journal

E2F1 (E2F transcription factor 1)

GAS6 overexpression

4years

The crosstalk between AXL and YAP promotes tumor progression through STAT3 activation in head and neck squamous cell carcinoma. (PubMed, Cancer Sci)

Mechanistically, Gas6 induced a competitive binding to phosphorylated signal transducers and activators of transcription 3 (STAT3) with large tumor suppressor kinase 1 (LATS1) and inhibited the Hippo pathway. This study revealed a novel non-transcriptional effect of STAT3 in Gas6/AXL-induced YAP activity, suggesting that STAT3 acted as a critical "molecular switch" during the mutual promotion between AXL and YAP, which might be a promising therapeutic target in HNSCC.

4 years ago

Journal

AXL (AXL Receptor Tyrosine Kinase) • STAT3 (Signal Transducer And Activator Of Transcription 3) • GAS6 (Growth arrest specific 6)

AXL expression • AXL overexpression • GAS6 overexpression

over4years

Overexpression of GAS6 Promotes Cell Proliferation and Invasion in Bladder Cancer by Activation of the PI3K/AKT Pathway. (PubMed, Onco Targets Ther)

Treatment of BCa cells with SC79, an AKT activator, partially restored the effect of GAS6 silencing on cell proliferation and invasion. The present study suggests that GAS6 may play a pivotal role in the development of BCa and may be a potential target for its treatment.

over 4 years ago

Journal

AXL (AXL Receptor Tyrosine Kinase) • GAS6 (Growth arrest specific 6)

GAS6 overexpression