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    BIOMARKER:

    GAS6 elevation

    i
    Other names: GAS6, Growth arrest specific 6
    Entrez ID:
    2621
    Related biomarkers:
    Expression
    Others
    4years
    [VIRTUAL] Preoperative Serum Axl/Gas6 Allow Stratification of Oncological Outcome in Patients Undergoing Liver Resection for Hepatocellular Carcinoma (IHPBA 2020)
    The present data underlines a potential benefit of incorporation of Axl/Gas6 in clinical routine. Especially combination with other biological markers could further increase validity. Accordingly, clinical decision making and treatment evaluation could be adapted in concordance with these markers.
    Clinical
    |
    AXL (AXL Receptor Tyrosine Kinase) • GAS6 (Growth arrest specific 6)
    |
    GAS6 elevation
    4years
    [VIRTUAL] Targeting AXL Kinase Sensitizes Acute Myeloid Leukemia Stem and Progenitor Cells to Venetoclax Treatment (ASH 2020)
    To test whether targeting of the AXL/GAS6 pathway is a feasible treatment strategy for AML, in particular to eradicate LSCs, we developed SLC-391, a novel, potent and selective AXL inhibitor. Importantly, the combination of AXL inhibition plus venetoclax treatment was not toxic to normal BM cells from healthy donors. Hence, our findings identify a promising, improved and specific treatment strategy for AML, particularly patients with high AXL/GAS6 expression.
    IO biomarker
    |
    AXL (AXL Receptor Tyrosine Kinase) • GAS6 (Growth arrest specific 6)
    |
    GAS6 elevation
    |
    Venclexta (venetoclax) • SLC-391