^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    GAS5 (Growth Arrest Specific 5)

    i
    Other names: GAS5, Growth Arrest Specific 5, Small Nucleolar RNA Host Gene (Non-Protein Coding) 2, Growth Arrest Specific 5 (Non-Protein Coding), NCRNA00030, SNHG2, Growth Arrest Specific Transcript 5, Non-Protein Coding RNA 30, NONHSAG003504.2, HSALNG0008545
    14d
    Enhanced anticancer activity of nanoemulsified cardamom extract via modulation of apoptosis- and lncRNA-associated pathways in colorectal cancer cells. (PubMed, Biochem Biophys Rep)
    Bioinformatic analyses identified correlations between these lncRNAs and crucial genes involved in cell survival, migration, and angiogenesis, emphasizing possible lncRNA-miRNA-mRNA regulatory axes. The cardamom nanoemulsion demonstrates enhanced anticancer activity relative to the crude extract and could represent a novel therapeutic approach for colorectal cancer by modulating lncRNAs and related molecular pathways.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • MMP2 (Matrix metallopeptidase 2) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • MMP9 (Matrix metallopeptidase 9) • GAS5 (Growth Arrest Specific 5) • ANXA5 (Annexin A5)
    19d
    Retraction Note. (PubMed, Eur Rev Med Pharmacol Sci)
    These articles have been retracted. The Publisher apologizes for any inconvenience this may cause.
    Journal
    |
    NOTCH1 (Notch 1) • TNFA (Tumor Necrosis Factor-Alpha) • S100A8 (S100 Calcium Binding Protein A8) • FOXP1 (Forkhead Box P1) • MMP9 (Matrix metallopeptidase 9) • GAS5 (Growth Arrest Specific 5) • SNAI1 (Snail Family Transcriptional Repressor 1) • MIR183 (MicroRNA 183) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)
    2ms
    Study on the Role of Long Non-Coding RNA GAS5 in Promoting the Malignant Progression of Prostate Cancer by Regulating miR-12/GPRC5B Signaling Axis. (PubMed, Bull Exp Biol Med)
    Thus, GPRC5B is directly bound to miR-12. GAS5 promotes proliferation, migration, and invasion of prostate cancer cells and participates in malignant progression of tumors by suppressing miR-12-mediated regulation of GPRC5B expression.
    Journal
    |
    GAS5 (Growth Arrest Specific 5)
    2ms
    Exploring the role of long non-coding RNAs in renal cell carcinoma: insights into signaling pathways. (PubMed, Cancer Cell Int)
    These insights into lncRNA-mediated regulatory mechanisms provide promising therapeutic targets for RCC, suggesting that modulating specific lncRNAs or their associated pathways could offer innovative strategies for treatment and prognosis. This review presents a comprehensive analysis of the biogenesis, functions, and regulatory roles of lncRNAs in RCC, emphasizing their potential as diagnostic biomarkers and therapeutic targets to improve patient outcomes.
    Review • Journal
    |
    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • HOTAIR (HOX Transcript Antisense RNA) • GAS5 (Growth Arrest Specific 5) • MEG3 (Maternally Expressed 3)
    3ms
    A Comprehensive multi-network analysis of ceRNAs and transcription factors for papillary thyroid carcinoma diagnosis and prognosis. (PubMed, Sci Rep)
    PKMYT1 and GAS5 demonstrated strong diagnostic value in distinguishing high-aggressive from low-aggressive tumors, while circMET showed notable diagnostic efficacy in differentiating low-aggressive PTC tumors from adjacent normal tissues. Furthermore, GAS5 expression levels were correlated with blood calcium levels.
    Journal
    |
    STAT6 (Signal transducer and activator of transcription 6) • GAS5 (Growth Arrest Specific 5) • NFATC1 (Nuclear Factor Of Activated T Cells 1) • NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) • PKMYT1 (Protein Kinase Membrane Associated Tyrosine/Threonine 1) • E2F1 (E2F transcription factor 1) • E2F3 (E2F transcription factor 3) • LINC02910 (Long Intergenic Non-Protein Coding RNA 2910)
    3ms
    Molecular Implications of ADIPOQ, GAS5, GATA4, and YAP1 Methylation in Triple-Negative Breast Cancer Prognosis. (PubMed, Int J Mol Sci)
    This study highlights the potential prognostic significance of the epigenetic regulation of ADIPOQ in TNBC. The in silico findings shed light on the molecular pathways associated with TNBC progression and warrant further investigation to validate their role in clinical outcomes and underlying biological mechanisms.
    Journal
    |
    YAP1 (Yes associated protein 1) • GAS5 (Growth Arrest Specific 5)
    4ms
    Ailanthone: A multi-targeting Quassinoid from Ailanthus altissima for broad-spectrum cancer therapy - a comprehensive review of mechanisms, pharmacokinetics, and clinical prospects. (PubMed, J Ethnopharmacol)
    Ailanthone exhibits significant, effective, broad-spectrum anti-tumor effects with multiple targets and mechanisms in both in vitro and in vivo models. However, challenges remain for its clinical application of ailanthone due to its short half-life, low bioavailability and off-target effects. Chemical proteomic strategies, structure-activity relationship (SAR) optimization, delivery systems and combination strategies are urgently needed to overcome these challenges.
    PK/PD data • Review • Journal
    |
    PD-L1 (Programmed death ligand 1) • KMT2A (Lysine Methyltransferase 2A) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • CHEK2 (Checkpoint kinase 2) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CHEK1 (Checkpoint kinase 1) • GAS5 (Growth Arrest Specific 5) • RPA1 (Replication Protein A1) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) • JUN (Jun proto-oncogene) • UPF1 (UPF1 RNA Helicase And ATPase)
    4ms
    Long non-coding RNA GAS5 alleviates inflammation in acute gouty arthritis via targeting miR-485-5p. (PubMed, Cent Eur J Immunol)
    The link between miR-485-5p and GAS5 was established in MSU-induced THP-1 macrophages. In summary, GAS5 alleviated MSU-induced excessive inflammation in THP-1 macro- phages by targeting miR-485-5p, suggesting that GAS5 is a potential diagnostic biomarker for AGA treatment.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • GAS5 (Growth Arrest Specific 5) • MIR485 (MicroRNA 485)
    5ms
    Restoring Tamoxifen Sensitivity in Breast Cancer: The Role of lncRNA MALAT1 and NanoCurcumin as Modulators of Drug Resistance. (PubMed, Biomed Res Int)
    Our findings suggest that NanoCurcumin mitigates tamoxifen resistance by downregulating MALAT1, offering a novel epigenetic strategy to enhance endocrine therapy efficacy. Further studies should explore lncRNA-targeted interventions to improve treatment outcomes in ER+ breast cancer.
    Journal
    |
    ER (Estrogen receptor) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • HOTAIR (HOX Transcript Antisense RNA) • GAS5 (Growth Arrest Specific 5) • CYTOR (Cytoskeleton Regulator RNA)
    |
    ER positive
    |
    tamoxifen
    6ms
    Retraction: Long Noncoding RNA GAS5 Suppresses Tumorigenesis by Inhibiting miR-23a Expression in Non-Small Cell Lung Cancer. (PubMed, Oncol Res)
    [This retracts the article DOI: 10.3727/096504016X14822800040451.].
    Journal
    |
    GAS5 (Growth Arrest Specific 5) • MIR23A (MicroRNA 23a)