P=N/A, N=392, Active, not recruiting, Xiamen University | Not yet recruiting --> Active, not recruiting | Trial completion date: Dec 2024 --> Mar 2025 | Trial primary completion date: Mar 2024 --> Mar 2025
17 days ago
Enrollment closed • Trial completion date • Trial primary completion date
P1, N=150, Active, not recruiting, Boston Medical Center | Recruiting --> Active, not recruiting | Trial primary completion date: Apr 2028 --> Jul 2028
Our research confirms a widespread HR-HPV infection in our population and extends the importance of studies on the molecular prevalence of HPV, particularly in women with normal cytology and apparent good health, in view of the cruel lack of public awareness of HPV infections.
In Greece, we observed a high HPV-AF (52.1%) in OPC, approximating the AFs reported for some Northern European countries. HPV+ versus HPV- patients were younger, more frequently with tonsillar tumors, and less frequently at TNM stage IV. Since most patients were infected by ≥1 HPV type targeted by the 9-valent vaccine, the HPV+ OPC burden could be mitigated through a routine HPV gender-neutral vaccination program.
P3, N=1000, Active, not recruiting, Imperial College London | Not yet recruiting --> Active, not recruiting | Trial completion date: Jul 2023 --> Aug 2025 | Trial primary completion date: Jul 2023 --> Aug 2025
2 months ago
Enrollment closed • Trial completion date • Trial primary completion date
For the HGSIL and cancer samples, 88% of the samples had full HPV genotype coverage with the 9-valent HPV vaccine. This study highlights a presence of HPV that will not be protected by vaccination in a high-risk population.
In total, 95.2% of HPV-driven HNC were attributed to HPV genotypes included in the 9-valent HPV vaccine being HPV16 the most prominent genotype. These results suggest that an epidemiologic shift is happening in Japan, with a decrease in smoking and alcohol use and an increase in HPV-driven HNC. The increasing trend of HPV-driven HNC in Japan highlights the need for preventive strategies to mitigate the rise of HPV-driven HNC.
P4, N=48, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: May 2024 --> May 2025 | Trial primary completion date: May 2024 --> May 2025
7 months ago
Trial completion date • Trial primary completion date
A higher regression rate than expected was observed in the surveillance arm of this prospective trial. Future clinical trials with imiquimod targeting CIN3 patients are warranted.
8 months ago
P2 data • Journal
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CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
P4, N=757, Active, not recruiting, The University of Texas Medical Branch, Galveston | Recruiting --> Active, not recruiting | Trial completion date: Mar 2025 --> Mar 2026 | Trial primary completion date: Feb 2024 --> Mar 2025
8 months ago
Enrollment closed • Trial completion date • Trial primary completion date
P1, N=33, Not yet recruiting, National Cancer Institute (NCI) | Initiation date: Nov 2023 --> Apr 2024 | Trial primary completion date: Nov 2025 --> Apr 2026
10 months ago
Trial initiation date • Trial primary completion date