EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MET (MET proto-oncogene, receptor tyrosine kinase) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • MSI (Microsatellite instability) • RET (Ret Proto-Oncogene) • FGFR2 (Fibroblast growth factor receptor 2) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • NRG1 (Neuregulin 1) • VEGFA (Vascular endothelial growth factor A) • RNF43 (Ring Finger Protein 43) • TYK2 (Tyrosine Kinase 2) • NTRK (Neurotrophic receptor tyrosine kinase)

BRAF V600E • KRAS mutation • EGFR mutation • MSI-H/dMMR • HER-2 overexpression • HER-2 amplification • PIK3CA mutation • BRAF V600 • MET amplification • RET fusion • FGFR2 mutation • PALB2 mutation • FGFR2 fusion • MET mutation • IDH mutation + BRAF V600E • IDH mutation + NTRK fusion

The efficacy and safety of immunoradiotherapy plus gemcitabine, apatinib, and PD-L1 monoclonal antibody as first-line treatment for unresectable biliary tract tumors. (ChiCTR2500111695)

P=N/A, N=33, Completed, Nanjing Drum Tower Hospital; Nanjing Drum Tower Hospital

4 days ago

New trial

gemcitabine • AiTan (rivoceranib)

NIOFA-02: A Randomized, Open-Label Cohort Study of Adebrelimab Combined with NALIRIFOX or Gemcitabine-Cisplatin (GC) as First-Line Treatment for Locally Advanced or Metastatic Biliary Tract Cancer (ChiCTR2600116738)

P4, N=102, Not yet recruiting, West China Hospital, Sichuan University; West China Hospital, Sichuan University

4 days ago

New P4 trial

cisplatin • gemcitabine • 5-fluorouracil • oxaliplatin • leucovorin calcium • Onivyde (nanoliposomal irinotecan) • AiRuiLi (adebrelimab)

A single-arm phase II clinical trial of HIPEC in combination with CRS and durvalumab for the treatment of biliary tract tumors with peritoneal metastases (ChiCTR2500115410)

P4, N=33, Not yet recruiting, The Third Affiliated Hospital of Naval Medical University; The Third Affiliated Hospital of Naval Medical University

4 days ago

New P4 trial

Imfinzi (durvalumab)

Gemcitabine and Nab-Paclitaxel Combined With Iparomlimab-Tuvorilimab for Advanced Gallbladder Cancer (ChiCTR2600117584)

P2, N=44, Not yet recruiting, Xinhua Hospital Affiliated to Shanghai Jiaotong University of Medicine; Xinhua Hospital Affiliated to Shanghai Jiaotong University of Medicine

4 days ago

New P2 trial

gemcitabine • albumin-bound paclitaxel • Ojemda (tovorafenib) • iparomlimab (QL1604)

Trastuzumab Combined With Chemotherapy and Leflunomide for HER2-Expressing Unresectable Advanced Biliary Tract Malignancies: An Open-Label, Single-Arm, Phase II Study (ChiCTR2500112844)

P2, N=53, Not yet recruiting, The Third Affiliated Hospital of Naval Medical University (Shanghai Eastern Hepatobiliary Surgery Hospital); The Third Affiliated Hospital of Naval Me

4 days ago

New P2 trial

HER-2 (Human epidermal growth factor receptor 2)

HER-2 positive • HER-2 amplification • HER-2 expression • HER-2 underexpression

Herceptin (trastuzumab) • leflunomide

Liposomal Irinotecan Plus 5-FU/LV Compared with Sequential Alternating nab-Paclitaxel Plus S-1 as Second-Line Therapy in Patients with Advanced Biliary Tract Cancer: A Randomized, Open-Label, Prospective Trial (ChiCTR2500111686)

P2, N=58, Not yet recruiting, Harbin Medical University Cancer Hospital; Harbin Medical University Cancer Hospital

4 days ago

New P2 trial

5-fluorouracil • albumin-bound paclitaxel • Teysuno (gimeracil/oteracil/tegafur)

A Single-Arm, Single-Center, Phase II Clinical Study of Sacituzumab Tirumotecan (Sac-TMT) for Second-Line or Later Treatment of Advanced or Metastatic Biliary Tract Cancer (ChiCTR2500112219)

P2, N=31, Not yet recruiting, The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University

4 days ago

New P2 trial

Jiataile (sacituzumab tirumotecan)

Single arm, multi center, open phase Ib/IIa clinical study on the efficacy and safety of JJH201601 liposome for injection in the treatment of advanced pancreatic cancer, biliary tract cancer and hepatocellular carcinoma (ChiCTR2500111729)

P1/2, N=90, Recruiting, Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University); Jiangsu Province Hospital (The First Affiliated Hospital wi

4 days ago

New P1/2 trial

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer. (PubMed, Phytother Res)

In vivo, SS suppressed tumor growth by subcutaneous and orthotopic models with no systemic toxicity. Our findings reveal SS as a novel APT2-targeted ferroptosis inducer that inhibits GBC progression via inhibiting the depalmitoylation process of STAT3, providing a safe and effective therapeutic candidate for this intractable malignancy.

6 days ago

Journal

STAT3 (Signal Transducer And Activator Of Transcription 3) • GPX4 (Glutathione Peroxidase 4) • SLC7A11 (Solute Carrier Family 7 Member 11)