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    GENE:

    GADD45G (Growth Arrest And DNA Damage Inducible Gamma)

    i
    Other names: GADD45G, Growth Arrest And DNA Damage Inducible Gamma, DDIT2, CR6, GADD45gamma, GRP17, Growth Arrest And DNA Damage-Inducible Protein GADD45 Gamma, DNA Damage-Inducible Transcript 2 Protein, Cytokine-Responsive Protein CR6, Gadd-Related Protein, 17 KD, DDIT-2, Growth Arrest And DNA-Damage-Inducible, Gamma, Growth Arrest And DNA-Damage-Inducible Gamma, GADD45-Gamma
    Associations

    News

    Trials
    26d
    Unresolved questions on the GADD45GIP1-RPL35 axis in osteosarcoma: mechanistic links to ER stress and therapeutic targeting. (PubMed, Cancer Cell Int)
    The model also necessitates validation across the spectrum of osteosarcoma's genetic heterogeneity. This letter critically examines these mechanistic ambiguities and proposes essential experiments to validate the model, assess its therapeutic viability, and define its clinical relevance within the complex landscape of osteosarcoma biology.
    Journal
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    GADD45G (Growth Arrest And DNA Damage Inducible Gamma)
    3ms
    A prognostic gene signature derived from aging-related genes predicts survival, immune landscape and therapy response in glioma. (PubMed, Mol Clin Oncol)
    RT-qPCR results further confirmed differential expression patterns of the 8 genes between normal and GBM cells, supporting their involvement in GBM pathogenesis. This 8-gene risk model effectively predicts glioma prognosis and supports personalized treatment strategies by highlighting immune microenvironment differences and drug sensitivities between risk groups.
    Journal • Gene Signature
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    GADD45G (Growth Arrest And DNA Damage Inducible Gamma) • GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2) • RBP1 (Retinol Binding Protein 1)
    4ms
    Cisplatin resistance in head and neck squamous cell carcinoma is linked to DNA damage response and cell cycle arrest transcriptomics rather than poor drug uptake. (PubMed, Cancer Drug Resist)
    In the TCGA cohort, multivariate analysis showed that high FANCD2 expression was associated with unfavorable recurrence-free survival in platinum-treated patients (hazard ratio = 4.0; P = 0.011), but not in those who did not receive platinum chemotherapy. Cisplatin resistance in HNSCC appears to be driven primarily by molecular mechanisms involving DNA damage response and cell cycle arrest pathways, rather than poor drug uptake.
    Journal
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    CASP3 (Caspase 3) • PPP1R15A (Protein Phosphatase 1 Regulatory Subunit 15A) • CASP7 (Caspase 7) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • FANCD2 (FA Complementation Group D2) • GADD45G (Growth Arrest And DNA Damage Inducible Gamma)
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    cisplatin
    5ms
    GADD45G as a novel prognostic biomarker and therapeutic target in glioma: integrative analysis of bulk and single-cell RNA sequencing. (PubMed, Front Oncol)
    GADD45G expression is significantly associated with glioma outcomes and may serve as a promising biomarker for prognosis evaluation. Its involvement in regulating EMT-like phenotypic traits further highlights its therapeutic potential.
    Journal
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    GADD45G (Growth Arrest And DNA Damage Inducible Gamma)
    6ms
    Identification of EMT-related subtype and a 9 genes signature predicts the prognosis in osteosarcoma. (PubMed, Connect Tissue Res)
    Two EMT-related subtypes with distinct immune features were identified, aiding clinical decision-making. A model comprising 9 genes offers a dependable means of predicting osteosarcoma prognosis.
    Journal
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    EPHB3 (EPH Receptor B3) • FADS2 (Fatty Acid Desaturase 2) • GADD45G (Growth Arrest And DNA Damage Inducible Gamma)
    8ms
    GADD45GIP1 promotes osteosarcoma progression by modulating RPL35 ubiquitination and alleviating endoplasmic reticulum stress via the PERK/eIF2α pathway. (PubMed, Cancer Cell Int)
    Thus, the high expression of GADD45GIP1 in osteosarcoma has been shown to inhibit the ubiquitin-mediated degradation of RPL35 and induce ER stress through the activation of the PERK-eIF2α pathway, thereby promoting the progression of osteosarcoma. This indicates that GADD45GIP1 serves as a key driver in the development of osteosarcoma and is a potential target for the prevention and therapy of osteosarcoma.
    Journal
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    GADD45G (Growth Arrest And DNA Damage Inducible Gamma)
    11ms
    A gene signature associated with cellular senescence serves as an important prognostic indicator in hepatocellular carcinoma. (PubMed, Transl Cancer Res)
    This study established a prognostic model of HCC based on cellular senescence-related gene expression. Our findings may provide insights that can be used to develop novel potential targeted therapies.
    Journal • Gene Signature
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    HRAS (Harvey rat sarcoma viral oncogene homolog) • CD8 (cluster of differentiation 8) • MAP2K2 (Mitogen-activated protein kinase kinase 2) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • MYBL2 (MYB Proto-Oncogene Like 2) • CDC25A (Cell Division Cycle 25A) • E2F5 (E2F Transcription Factor 5) • GADD45G (Growth Arrest And DNA Damage Inducible Gamma) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • RHEB (Ras Homolog, MTORC1 Binding) • RAD9A (RAD9 Checkpoint Clamp Component A)
    1year
    Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1. (PubMed, Front Oncol)
    Analysis of gene expression by qRT-PCR and differential gene expression revealed that GADD45g genes can be effective genes in the proliferation of oncolytic HSV-1 virus. The transcriptome changes in tumor cells infected by oHSV-1 may be utilized to predict oncolytic efficacy and provide rational strategies for designing next-generation oncolytic viruses.
    Journal • IO biomarker
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    PSMD4 (Proteasome 26S Subunit Non-ATPase 4) • PSMA2 (Proteasome 20S Subunit Alpha 2) • PSMC2 (Proteasome 26S Subunit, ATPase 2) • PSMD1 (Proteasome 26S Subunit Non-ATPase 1) • GADD45G (Growth Arrest And DNA Damage Inducible Gamma) • PSMD14 (Proteasome 26S Subunit, Non-ATPase 14)
    over1year
    Identification of Biomarkers and Mechanisms Associated with Apoptosis in Recurrent Pregnancy Loss. (PubMed, Biochem Genet)
    We identified six differentially expressed genes related to apoptosis in RPL, with GADD45G as the most important. NOD-like receptor signaling pathway and regulation of actin cytoskeleton could be therapeutic targets for RPL.
    Journal • IO biomarker
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    KRAS (KRAS proto-oncogene GTPase) • BCL2 (B-cell CLL/lymphoma 2) • PIK3CD (Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta) • CD4 (CD4 Molecule) • CASP8 (Caspase 8) • GADD45G (Growth Arrest And DNA Damage Inducible Gamma)
    over1year
    Correlation with Apoptosis Process through RNA-Seq Data Analysis of Hep3B Hepatocellular Carcinoma Cells Treated with Glehnia littoralis Extract (GLE). (PubMed, Int J Mol Sci)
    In summary, we investigated the RNA-seq dataset of GLE to identify potential targets that may be involved in the apoptotic process in HCC. These goals may aid in the identification and management of HCC.
    Journal
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    PPP1R15A (Protein Phosphatase 1 Regulatory Subunit 15A) • CX3CL1 (C-X3-C Motif Chemokine Ligand 1) • DDIT3 (DNA-damage-inducible transcript 3) • ANXA5 (Annexin A5) • CHAC1 (ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1) • GADD45B (Growth Arrest And DNA Damage Inducible Beta) • GADD45G (Growth Arrest And DNA Damage Inducible Gamma) • HNF1A (HNF1 Homeobox A)
    over1year
    The role of GADD45G methylation in endometrial cancer: Insights into CDK1/CCNB1 activation and therapeutic opportunities. (PubMed, J Cancer Res Ther)
    This study demonstrated that the downregulation of GADD45G, mediated by methylation, facilitates the invasive behaviors of EC cells through interaction with the CDK1/CCNB1. These findings enhance understanding of the molecular mechanisms underlying endometrial cancer and suggest potential therapeutic strategies targeting GADD45G for treatment.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • CCNB1 (Cyclin B1) • GADD45G (Growth Arrest And DNA Damage Inducible Gamma)
    over1year
    Systematic bioinformatics analysis reveals the role of shikonin in blocking colon cancer progression by identifying senescence-induced genes. (PubMed, Front Pharmacol)
    Based on these findings, we deem that shikonin might induce senescence and exert antitumor activity in colon cancer cells by downregulating CDKN2A and CXCL8. This provides a new molecular mechanism and potential therapeutic target for shikonin to inhibit colon cancer progression.
    Journal
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • SQSTM1 (Sequestosome 1) • IGFBP3 (Insulin-like growth factor binding protein 3) • GADD45G (Growth Arrest And DNA Damage Inducible Gamma)