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    GENE:

    GADD45B (Growth Arrest And DNA Damage Inducible Beta)

    i
    Other names: GADD45B, Growth Arrest And DNA Damage Inducible Beta, GADD45BETA, MYD118, Growth Arrest And DNA Damage-Inducible Protein GADD45 Beta, Myeloid Differentiation Primary Response Protein MyD118, Negative Growth Regulatory Protein MyD118, DKFZP566B133, Growth Arrest And DNA-Damage-Inducible, Beta, Growth Arrest And DNA-Damage-Inducible Beta, Myeloid Differentiation Primary Response
    Associations

    News

    Trials
    1m
    Piecing Together the Puzzles: Aryl Hydrocarbon Receptor-Mediated Genetic and Epigenetic Signatures in Dioxin-Induced Carcinogenicity- A Systematic Review and Meta-Analysis. (PubMed, Toxicol Lett)
    Dioxin-induced carcinogenicity involves intricate AhR-mediated genetic damage and profound epigenetic reprogramming. These alterations, which are often cell-type and species-specific, disrupt critical cellular processes, including EMT and CSC biology, and are susceptible to transgenerational inheritance. The identified molecular signatures offer a foundation for improved biomarkers and targeted therapeutic interventions.
    Retrospective data • Journal
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    IL6 (Interleukin 6) • SLC7A5 (Solute Carrier Family 7 Member 5) • GADD45B (Growth Arrest And DNA Damage Inducible Beta)
    2ms
    Emerging role of FUS in TGFB1 and COL1A1 transcription dependent on GADD45B to induce NASH-fibrosis. (PubMed, J Mol Cell Biol)
    Ameliorated collagen deposition and decreased nuclear FUS content in HSCs were detected in Gadd45b KO mice. Overall, this study suggests that FUS and GADD45B could be potential treatment targets for NASH-fibrosis.
    Journal
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    FUS (FUS RNA Binding Protein) • TGFB1 (Transforming Growth Factor Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • GADD45B (Growth Arrest And DNA Damage Inducible Beta)
    3ms
    Transcriptome biomarkers of colon cancer liver metastasis response to neoadjuvant triplet chemotherapy: a case series. (PubMed, J Circ Biomark)
    The triplet FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) may be considered an effective option in the neoadjuvant setting for metastatic colon cancer (mCRC). Data obtained indicate transcriptional discordance between the primary tumors and liver metastases during neoadjuvant FOLFOXIRI, with the pattern of DEGs involved in their response being distinct. The EPS8L2 transcript could be regarded as a candidate biomarker of liver complete response; however, prognostic conclusions cannot be drawn from this cohort.
    Journal
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    IL7R (Interleukin 7 Receptor) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • SERPINE1 (Serpin Family E Member 1) • IL1RN (Interleukin 1 receptor antagonist) • NAMPT (Nicotinamide Phosphoribosyltransferase) • PER1 (Period Circadian Clock 1) • TAGLN (Transgelin) • ZBTB16 (Zinc Finger And BTB Domain Containing 16) • ATF3 (Activating Transcription Factor 3) • CTGF (Connective tissue growth factor) • DUSP1 (Dual Specificity Phosphatase 1) • GADD45B (Growth Arrest And DNA Damage Inducible Beta) • ISG20 (Interferon Stimulated Exonuclease Gene 20) • TSC22D3 (TSC22 Domain Family Member 3)
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    5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium
    4ms
    Gadd45B Deficiency Drives Radio-Resistance in BRAFV600E-Mutated Differentiated Thyroid Cancer by Disrupting Iodine Metabolic Genes. (PubMed, Cancers (Basel))
    Gadd45B plays a pivotal role in regulating the differentiation status and RAI sensitivity of BRAFV600E-mutated thyroid cancer. These findings identify Gadd45B as a promising therapeutic target for restoring RAI responsiveness in RAIR-DTC patients.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • GADD45B (Growth Arrest And DNA Damage Inducible Beta)
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    BRAF V600E • BRAF V600
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    PLX4720 • BIBR1532
    4ms
    Intergenic Variants Upstream of GADD45b Affect Survival of Micropterus salmoides Following LMBV Exposure. (PubMed, Int J Mol Sci)
    Additionally, dynamic expression levels of immune-related genes (IFN-γ, TNF-α, and IL-10) also varied among different genotypes. These results demonstrated that the two SNPs in GADD45b could be used as candidate markers for further investigation of selective breeding of resistant largemouth bass to LMBV.
    Journal
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    IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • GADD45B (Growth Arrest And DNA Damage Inducible Beta)
    6ms
    Epstein-Barr virus-coded miR-BART19-3p promotes proliferation of EBV-associated gastric cancer by inhibiting GADD45B. (PubMed, J Transl Med)
    Our study indicated Epstein-Barr Virus MicroRNA BART19-3p played an oncogenic role by a novel mechanism of inhibiting GADD45B in EBVaGC, which provides new insights and might be a potential therapeutic strategy for EBVaGC patients.
    Journal
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    GADD45B (Growth Arrest And DNA Damage Inducible Beta)
    6ms
    Screening of TNF signaling pathway-related genes in knee osteoarthritis (KOA) using WGCNA and machine learning. (PubMed, Medicine (Baltimore))
    Additionally, immune infiltration analysis revealed significant differences in immune cell distribution across knee arthritis samples, underscoring the critical role of inflammation regulation in disease progression. Overall, this study enhances the understanding of KOA pathogenesis and offers valuable insights for personalized treatment and, precision medicine.
    Journal
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    MCL1 (Myeloid cell leukemia 1) • TNFA (Tumor Necrosis Factor-Alpha) • GADD45B (Growth Arrest And DNA Damage Inducible Beta)
    7ms
    Genetic overlap between sarcoidosis and lung cancer: a combined in silico and in vitro approach. (PubMed, Hereditas)
    Overall, this study highlights shared pathogenic signatures between sarcoidosis and LC and proposes metformin as a promising therapeutic candidate. These findings support the rationale for drug repurposing and the development of targeted therapies for patients with overlapping disease profiles or those at increased risk of LC progression from sarcoidosis.
    Preclinical • Journal
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    KLF4 (Kruppel-like factor 4) • SALL4 (Spalt Like Transcription Factor 4) • WIF1 (WNT Inhibitory Factor 1) • GADD45B (Growth Arrest And DNA Damage Inducible Beta)
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    metformin
    7ms
    Comprehensive transcriptomic analysis of hepatocellular Carcinoma: Uncovering shared and unique molecular signatures across diverse etiologies. (PubMed, Biochem Biophys Rep)
    These findings provide a robust molecular framework for HCC subtyping and prioritize novel biomarkers and therapeutic targets for further validation. This resource advances the potential for personalized HCC diagnostics and therapies.
    Journal
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    CCNE1 (Cyclin E1) • TYMS (Thymidylate Synthetase) • SLC22A1 (Solute Carrier Family 22 Member 1) • CDK1 (Cyclin-dependent kinase 1) • CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9) • CCNB1 (Cyclin B1) • GADD45B (Growth Arrest And DNA Damage Inducible Beta)
    9ms
    Inhibiting NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis: A New Role of GADD45B's Role in Hypertriglyceridemia-Induced Acute Pancreatitis. (PubMed, Discov Med)
    This study revealed that GADD45B downregulation reduces pyroptosis by suppressing the NLRP3/Caspase-1/GSDMD axis in HTG-AP, underscoring GADD45B as a promising therapeutic target and enhancing its clinical application.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL18 (Interleukin 18) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • GADD45B (Growth Arrest And DNA Damage Inducible Beta) • CASP1 (Caspase 1)
    10ms
    Integrated bioinformatic analysis identifies GADD45B as an immune-related prognostic biomarker in skin cutaneous melanoma. (PubMed, Hereditas)
    In conclusion, our findings highlight GADD45B as a key regulator in SKCM progression, capable of restraining tumor cell proliferation and enhancing apoptosis. GADD45B holds promise as a novel diagnostic and prognostic biomarker and a potential target for SKCM immunotherapy.
    Journal • IO biomarker
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    GADD45B (Growth Arrest And DNA Damage Inducible Beta)
    10ms
    The key pathways and genes related to oncolytic Newcastle disease virus-induced phenotypic changes in ovarian cancer cells. (PubMed, J Microbiol)
    Among these pathways, 48 DEGs, especially SESN2, HLA B/C/E, GADD45B, and RELA, that may be involved in the oncolytic process were screened, and qPCR analysis verified the reliability of the transcription data. This study discovered some key pathways and genes related to oncolytic NDV-induced phenotypic changes in ovarian cancer cells, which will guide our future research directions and help further explore the specific mechanisms by which infection with NDV suppresses ovarian cancer development.
    Journal
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    SESN2 (Sestrin 2) • GADD45B (Growth Arrest And DNA Damage Inducible Beta) • RELA (RELA Proto-Oncogene)