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    BIOMARKER:

    GADD45A overexpression

    i
    Other names: GADD45A, DDIT1, GADD45, Growth arrest and DNA-damage-inducible, alpha
    Entrez ID:
    1647
    Related biomarkers:
    Expression
    Associations

    News

    Trials
    over2years
    GADD45A IS OVER-EXPRESSED IN THE BONE MARROW OF PATIENTS WITH DE NOVO ACUTE MYELOID LEUKEMIA REFRACTORY TO INDUCTION CHEMOTHERAPY (EHA 2022)
    Aims The aim of this study was to investigate the possible alterations in the gene expression profile of DNA damage signaling pathways in two leukemic cell lines following their exposure to chemotherapeutic agents, namely, idarubicin and cytarabine, and verify the findings in AML patient samples at diagnosis before the onset of chemotherapy. Both genes are likely to play an important role in the pathogenesis of AML. Furthermore, GADD45A overexpression appears to be related with resistance to induction treatment, which may have significant prognostic and therapeutic implications.
    Clinical
    |
    PPP1R15A (Protein Phosphatase 1 Regulatory Subunit 15A) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • GADD45G (Growth Arrest And DNA Damage Inducible Gamma)
    |
    KIT expression • GADD45A overexpression
    |
    cytarabine • idarubicin hydrochloride