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    GENE:

    GABARAPL1 (GABA Type A Receptor Associated Protein Like 1)

    i
    Other names: GABARAPL1, GABA Type A Receptor Associated Protein Like 1, APG8L, ATG8L, ATG8B, Gamma-Aminobutyric Acid Receptor-Associated Protein-Like 1, GABA(A) Receptor-Associated Protein-Like 1, Glandular Epithelial Cell Protein 1, Early Estrogen-Regulated Protein, Gec1, GEC1, GABA(A) Receptor-Associated Protein Like 1, APG8-LIKE, GEC-1, ATG8
    Associations

    News

    Trials
    2ms
    Peptide OH-CATH30 Mitigates Cachexia-Induced Muscle Atrophy via Modulation of TLR4-Associated Inflammation. (PubMed, J Cachexia Sarcopenia Muscle)
    Our findings underscore the critical role of TLR4 signalling in cachexia-associated muscle wasting across different disease contexts and demonstrate the efficacy of OH-CATH30, a TLR4 inhibitor, in alleviating muscle atrophy in various cachexia models.
    Journal • IO biomarker
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CD14 (CD14 Molecule) • TLR4 (Toll Like Receptor 4) • FBXO32 (F-Box Protein 32) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1) • IRAK4 (Interleukin 1 Receptor Associated Kinase 4)
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    cisplatin
    2ms
    Decrypting potential mechanisms linking ochratoxin A to hepatocellular carcinoma: an integrated approach combining toxicology, machine learning, molecular docking, and molecular dynamics simulation. (PubMed, BMC Pharmacol Toxicol)
    This integrated computational study identifies a set of candidate genes through which OTA may potentially interact with HCC-associated molecular networks. The robust binding predicted between OTA and the core targets provides a structural basis for these interactions. These findings offer a prioritized list of targets and a theoretical framework for subsequent experimental validation and investigation into OTA's toxicological role in HCC.
    Journal
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    GSTP1 (Glutathione S-transferase pi 1) • LMNA (Lamin A/C) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • AURKA (Aurora kinase A) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1)
    6ms
    CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression. (PubMed, Cell Death Discov)
    These findings establish G2E3 as a novel ubiquitin-related regulator of autophagy, specifically facilitating autophagosome-lysosome fusion via a GABARAPs-dependent mechanism. This study reveals a previously unrecognized role of G2E3 in late-stage autophagy and suggests that targeting G2E3 could provide a potential therapeutic approach for modulating autophagy-dependent cellular processes, including cancer progression.
    Journal
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    LAMP1 (Lysosomal Associated Membrane Protein 1) • GABARAP (GABA Type A Receptor-Associated Protein) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1)
    6ms
    Integration of autophagy-related genes and immune dysregulation reveals a prognostic landscape in multiple myeloma. (PubMed, Front Oncol)
    This autophagy-related gene signature provides a reliable prognostic tool for MM, highlighting immune dysregulation and therapeutic resistance mechanisms. Its integration with clinical parameters enhances risk stratification and treatment planning.
    Journal
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    CD70 (CD70 Molecule) • BTLA (B And T Lymphocyte Associated) • CD48 (CD48 Molecule) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1)
    7ms
    Prognostic implications of autophagy and pyroptosis related genes in oral squamous cell carcinoma: research on bioinformatics and experiments. (PubMed, Front Oncol)
    In particular, BAK1 emerges as an independent prognostic marker with high diagnostic potential. These results offer promising insights into the development of gene-targeted therapies for OSCC, with BAK1 representing a potential therapeutic target.
    Journal
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    CD22 (CD22 Molecule) • ATG5 (Autophagy Related 5) • BAK1 (BCL2 Antagonist/Killer 1) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1)
    8ms
    Analysis of novel therapeutic targets and construction of a prognostic model for hepatocellular carcinoma. (PubMed, PeerJ)
    This study, for the first time, integrated multi-omics data and experimental verification to establish a prognostic model of HCC based on the ferroptosis gene. It can be used to dynamically monitor HCC using blood tests and provide a new target for personalized immunotherapy.
    Journal • IO biomarker
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    FLT3 (Fms-related tyrosine kinase 3) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • SLC1A5 (Solute Carrier Family 1 Member 5) • SLC7A11 (Solute Carrier Family 7 Member 11) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1)
    1year
    ESCRT iii-mediated lysosomal repair improve renal tubular cell injury in cisplatin-induced AKI. (PubMed, Autophagy)
    In conclusion, our study indicates that ESCRT III-mediated lysosomal repair can relieve cisplatin-induced cell apoptosis and restore normal autophagy function in renal tubular epithelial cells. This mechanism plays a protective role against cisplatin-induced AKI.
    Journal
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    SQSTM1 (Sequestosome 1) • LGALS3 (Galectin 3) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1)
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    cisplatin
    1year
    Identification of Causal Plasma Proteins in Hepatocellular Carcinoma via Two-sample Mendelian Randomization and Integrative Transcriptomic‒Proteomic Analysis. (PubMed, Cancer Res Commun)
    Potential drugs included ASS1 with arginine, aspartic acid, and citrulline; KRT8 with ambroxol, diltiazem, and amikacin; and STOML2 with chlortetracycline, chlorzoxazone, and dirithromycin. This study identified several novel causal plasma proteins, providing new insights into the early diagnosis and treatment of HCC.
    Journal
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    B2M (Beta-2-microglobulin) • ASS1 (Argininosuccinate synthase 1) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1)
    1year
    MEK5-ERK5 pathway mediates mitophagy by regulating Nur77 to promote tumorigenesis of osteosarcoma cells. (PubMed, Eur J Med Res)
    MEK5-ERK5 pathway mediates mitophagy by regulating Nur77 to promote tumorigenesis of OS cells. These findings offered promising therapeutic targets for OS.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1) • RB1CC1 (RB1 Inducible Coiled-Coil 1)
    over1year
    Identifying a CD8T cell signature in the tumor microenvironment to forecast gastric cancer outcomes from sequencing data. (PubMed, J Gastrointest Oncol)
    A CD8T cell-related signature demonstrated robust prognostic predictive performance for GC. Our findings may reveal novel insights into the diagnosis and treatment of GC.
    Journal
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    CXCR4 (Chemokine (C-X-C motif) receptor 4) • TNFA (Tumor Necrosis Factor-Alpha) • CLDN1 (Claudin 1) • ERRFI1 (ERBB Receptor Feedback Inhibitor 1) • TCEAL9 (Transcription Elongation Factor A Like 9) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • CD59 (CD59 Molecule) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1) • RGS2 (Regulator Of G Protein Signaling 2) • SOCS3 (Suppressor Of Cytokine Signaling 3) • ZFP36 (ZFP36 Ring Finger Protein) • TSC22D3 (TSC22 Domain Family Member 3)
    over1year
    ZNF197-AS1/miR-425/GABARAPL1 Axis: A Novel Regulatory Mechanism in Uveal Melanoma. (PubMed, Am J Physiol Cell Physiol)
    These findings suggest that ZNF197-AS1 can effectively inhibit UM progression through this ceRNA regulatory network. This study provides valuable insights into the molecular mechanisms underlying UM and highlights the potential of targeting the ZNF197-AS1/miR-425/GABARAPL1 axis as a therapeutic strategy for UM.
    Journal
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    MIR425 (MicroRNA 425) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1)