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    BIOMARKER:

    GABARAP deletion

    i
    Other names: GABARAP, GABA Type A Receptor-Associated Protein, GABA(A) Receptor-Associated Protein, Gamma-Aminobutyric Acid Receptor-Associated Protein, MM46, Epididymis Secretory Sperm Binding Protein, GABARAP-A, ATG8A, FLC3B
    Entrez ID:
    11337
    almost2years
    Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma. (PubMed, Blood)
    Conversely, upregulating autophagy using rapamycin restored Golgi morphology, CRT exposure and ICD signaling in GABARAPKO cells undergoing bortezomib treatment. Therefore, coupling an ICD inducer, like bortezomib, with an autophagy inducer, like rapamycin, may improve patient outcomes in MM, where low GABARAP in the form of del(17p) is common and leads to worse outcomes.
    Journal
    |
    CALR (Calreticulin) • GABARAP (GABA Type A Receptor-Associated Protein)
    |
    Chr del(17p) • GABARAP deletion
    |
    bortezomib • sirolimus
    over4years
    Loss-of-function of GABARAP drives tumor resistance to bortezomib-induced immunogenic cell death in multiple myeloma (IMW 2021)
    our study demonstrates that loss- of-function of GABARAP, particularly in HR patients with 17p deletion, contributes to tumor immune evasion and ICD resistance. These studies provide the framework for novel combination treatments to restore anti-MM immunity and improve patient outcome in HR MM.
    IO biomarker
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • CALR (Calreticulin) • GABARAP (GABA Type A Receptor-Associated Protein)
    |
    GABARAP deletion
    |
    bortezomib