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almost2years
Ori-C101Chimeric Antigen Receptor (CAR) Modified T Cells for the Treatment of HCC (clinicaltrials.gov)
P1/2, N=105, Recruiting, OriCell Therapeutics Co., Ltd. | Not yet recruiting --> Recruiting
Enrollment open • Metastases
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GPC3 (Glypican 3)
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GPC3 expression
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Ori-C101
almost2years
New P1/2 trial • Metastases
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GPC3 (Glypican 3)
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GPC3 expression
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Ori-C101
over3years
[VIRTUAL] An armored GPC3-directed CAR-T for refractory or relapsed hepatocellular carcinoma in China: A phase I trial. (ASCO 2021)
Patients were pre-conditioned with fludarabine (25̃30 mg/m2) and cyclophosphamide (200̃300 mg/m2) daily for 3 days...Cytokine release syndrome (CRS) was observed in 8 patients, in which 6 at grade 1 or 2 and 2 at grade 4 notably infused with 3 x10e8 both via intravenous route and reversed within 7 days by administering high-dose steroids and tocilizumab... These initial data provide evidence that G3-CAR-ori2 is safe and holds promising antitumor potential, and supports its continuing development in the treatment of r/r GPC3+HCC.
P1 data • IO biomarker
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GPC3 (Glypican 3)
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fludarabine IV • Actemra IV (tocilizumab) • Ori-C101