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    BIOMARKER:

    G0S2 overexpression

    i
    Other names: G0S2, G0/G1 Switch 2, Putative Lymphocyte G0/G1 Switch Gene, G0/G1 Switch Regulatory Protein 2, G0/G1 Switch Protein 2, G0/G1switch 2
    Entrez ID:
    50486
    2ms
    Phenotype remodelling of HNSCC cells in the muscle invasion environment. (PubMed, J Transl Med)
    In this study, we profiled the transcriptional programs of muscle-invasive HNSCC cell populations and characterized their EMT and myoepithelial-like phenotypes. Furthermore, our findings highlight the presence of muscle-invasion as a predictive marker for HNSCC patients. G0S2 as one of the markers of muscle-invasive cancer cells is involved in HNSCC intravasation, probably via VEGF signalling.
    Journal
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    VEGFA (Vascular endothelial growth factor A) • G0S2 (G0/G1 Switch 2)
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    G0S2 overexpression
    over1year
    Acidosis-induced regulation of adipocyte G0S2 promotes crosstalk between adipocytes and breast cancer cells as well as tumor progression. (PubMed, Cancer Lett)
    Furthermore, we demonstrate that the adipocyte-specific overexpression of G0S2 impairs mammary tumor growth and lung metastasis formation in vivo. Our results highlight the importance of acidosis in cancer cell-adipocyte crosstalk and identify G0S2 as the main regulator of cancer-induced lipolysis, regulating tumor establishment and spreading.
    Journal
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    G0S2 (G0/G1 Switch 2)
    |
    G0S2 overexpression
    over1year
    G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells. (PubMed, Transl Oncol)
    Finally, we deleted G0S2 in breast cancer-prone MMTV-PyMT mice. Our data indicates a complex role for G0S2 in breast cancer, dependent on ER status, that may be partially mediated by suppression of the estrogen signaling pathway.
    Journal
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    ER (Estrogen receptor) • CDH1 (Cadherin 1) • ELF3 (E74 Like ETS Transcription Factor 3) • G0S2 (G0/G1 Switch 2) • TFF1 (Trefoil Factor 1) • TFF3 (Trefoil factor 3) • HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1) • HMGCS2 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 2) • TACSTD2 (Tumor Associated Calcium Signal Transducer 2)
    |
    G0S2 overexpression